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Arikayce Side Effects

Generic name: amikacin liposome

Medically reviewed by Drugs.com. Last updated on Jan 1, 2021.

Note: This document contains side effect information about amikacin liposome. Some of the dosage forms listed on this page may not apply to the brand name Arikayce.

For the Consumer

Applies to amikacin liposome: inhalation suspension

Warning

Inhalation route (Suspension)

Amikacin liposome has been associated with an increased risk of respiratory adverse reactions, including, hypersensitivity pneumonitis, hemoptysis, bronchospasm, and exacerbation of underlying pulmonary disease that have led to hospitalizations in some cases.

Side effects requiring immediate medical attention

Along with its needed effects, amikacin liposome (the active ingredient contained in Arikayce) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amikacin liposome:

More common

  • Cough
  • coughing or spitting up blood
  • difficulty breathing
  • dizziness
  • feeling of fullness in the ears
  • fever
  • loss of balance
  • loss of hearing
  • noisy breathing
  • ringing or buzzing in the ears
  • sore throat
  • tightness in the chest
  • trouble hearing
  • upper airway irritation
  • voice changes

Less common

  • Balance disorder
  • blue lips, fingernails, or skin
  • change in sputum
  • chest discomfort or pain
  • chills
  • cough producing mucus
  • general feeling of discomfort or illness
  • irregular, fast or slow, or shallow breathing
  • nosebleed
  • severe pain in the chest
  • sudden onset of severe breathing difficulty
  • thickening of bronchial secretions

Side effects not requiring immediate medical attention

Some side effects of amikacin liposome may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

  • Anxiety
  • change in taste
  • dry mouth
  • loss of taste

For Healthcare Professionals

Applies to amikacin liposome: inhalation suspension

General

The most commonly reported side effects included dysphonia, cough, bronchospasm, and hemoptysis.[Ref]

Respiratory

Very common (10% or more): Dysphonia (up to 47%), cough (up to 39%), bronchospasm (up to 29%), hemoptysis (up to 18%), upper airway irritation (up to 17%), exacerbation of underlying pulmonary disease (up to 15%)

Common (1% to 10%): Bronchitis, change in sputum, epistaxis, hypersensitivity pneumonitis, pneumonia, pneumothorax, respiratory failure

Frequency not reported: Acute respiratory failure, allergic alveolitis, aspiration pneumonia, asthma, atypical pneumonia, bronchial hyperreactivity, chronic obstructive pulmonary disease (COPD) exacerbation, dyspnea, dyspnea exertional, increased sputum, infective exacerbation of bronchiectasis, infective exacerbation of COPD, interstitial lung disease, laryngeal erythema, laryngeal pain, laryngitis, lower respiratory tract infection, lung infection, lung infection pseudomonas, oropharyngeal discomfort, oropharyngeal pain, pharyngeal edema, pharyngeal erythema, pleural effusion infection, productive cough, pneumomediastinum, pneumonia pseudomonas, pneumonitis, prolonged expiration, respiratory tract infection, spontaneous pneumothorax, sputum discolored, throat irritation, throat tightness, upper airway cough syndrome, upper airway inflammation, vocal cord inflammation, wheezing[Ref]

Other

Very common (10% or more): Ototoxicity (up to 17%), asthenia (up to 16%), fatigue (up to 16%)

Common (1% to 10%): Chest discomfort, exercise tolerance decreased, pyrexia

Frequency not reported: Body ache, deafness, exacerbation of underlying disease, hypoacusis, neurosensory deafness, pain, tinnitus, unilateral deafness[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (up to 13%), nausea (up to 12%)

Common (1% to 10%): Dry mouth, oral fungal infection, vomiting

Frequency not reported: Oral candidiasis, post-tussive vomiting[Ref]

Musculoskeletal

Very common (10% or more): Musculoskeletal pain (up to 17%)

Frequency not reported: Arthralgia, back pain, muscle spasm, muscle weakness, myalgia[Ref]

Nervous system

Common (1% to 10%): Balance disorder, dysgeusia, headache, neuromuscular disorder

Frequency not reported: Aphonia, dizziness, neuromuscular blockade, peripheral neuropathy, presyncope, vertigo[Ref]

Dermatologic

Common (1% to 10%): Rash

Frequency not reported: Drug eruption, maculopapular rash, urticaria[Ref]

Psychiatric

Common (1% to 10%): Anxiety[Ref]

Metabolic

Common (1% to 10%): Decreased weight[Ref]

Immunologic

Frequency not reported: Empyema, pseudomonas infection, sputum purulent[Ref]

Renal

Frequency not reported: Nephrotoxicity[Ref]

Frequently asked questions

References

1. "Product Information. Arikayce (amikacin liposome)." Insmed Incorporated, Bridgewater, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.