Amlodipine / Hydrochlorothiazide / Olmesartan Side Effects

Medically reviewed by Drugs.com. Last updated on May 8, 2024.

Applies to amlodipine / hydrochlorothiazide / olmesartan: oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet)

Drugs that act directly on the renin-angiotensin system can cause fetal toxicity, including injury and even death to the developing fetus.

When pregnancy is confirmed, discontinue immediately.

Serious side effects

Along with its needed effects, amlodipine/hydrochlorothiazide/olmesartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amlodipine/hydrochlorothiazide/olmesartan:

More common side effects

• bloating or swelling of the face, arms, hands, lower legs, or feet
• rapid weight gain
• tingling of the hands or feet
• unusual weight gain or loss

Less common side effects

• bladder pain
• bloody or cloudy urine
• body aches or pain
• cough
• difficult, burning, or painful urination
• difficulty with breathing
• fainting
• frequent urge to urinate
• headache
• loss of voice
• lower back or side pain
• swelling of the joints
• unusual tiredness or weakness

Incidence not known

• persistent non-healing sore
• pink growth
• reddish patch or irritated area
• shiny bump
• white, yellow or waxy scar-like area

Other side effects

Some side effects of amlodipine / hydrochlorothiazide / olmesartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• diarrhea
• muscle aches or spasms
• nausea

For healthcare professionals

Applies to amlodipine / hydrochlorothiazide / olmesartan: oral tablet.

General adverse events

The most common adverse reactions were dizziness, peripheral edema, and headache.^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, headache, syncope
• Uncommon (0.1% to 1%): Hypoesthesia, lethargy, paresthesia, postural dizziness, vertigo

Amlodipine:

• Common (1% to 10%): Dizziness, headache, somnolence
• Uncommon (0.1% to 1%): Hypoesthesia, paresthesia, syncope, tremor, tinnitus, postural dizziness, peripheral neuropathy
• Rare (less than 0.1%): Hypertonia, ataxia, migraine, amnesia, parosmia, taste perversion

Hydrochlorothiazide:

• Frequency not reported: Lightheadedness, vertigo, paresthesia

Olmesartan:

• Common (1% to 10%): Dizziness, headache
• Uncommon (0.1% to 1%): Vertigo
• Postmarketing reports: Lethargy^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, diarrhea
• Uncommon (0.1% to 1%): Constipation, dry mouth, dyspepsia, upper abdominal pain, vomiting

Amlodipine:

• Common (1% to 10%): Abdominal pain, nausea, dyspepsia
• Uncommon (0.1% to 1%): Altered bowel habits, dry mouth, vomiting, constipation, dysphagia, diarrhea, flatulence, pancreatitis, gingival hyperplasia
• Rare (less than 0.1%): Gastritis, loose stools

Hydrochlorothiazide:

• Frequency not reported: Sialadenitis, cramping, gastric irritation, diarrhea, constipation, pancreatitis

Olmesartan:

• Common (1% to 10%): Abdominal pain, diarrhea, dyspepsia, gastroenteritis, nausea
• Postmarketing reports: Vomiting, sprue-like enteropathy^[Ref]

Musculoskeletal

• Common (1% to 10%): Muscle spasms, joint swelling
• Uncommon (0.1% to 1%): Back pain, pain in extremity

Amlodipine:

• Common (1% to 10%): Muscle cramps
• Uncommon (0.1% to 1%): Arthralgia, back pain, myalgia, rigors, arthrosis
• Rare (less than 0.1%): Muscle weakness, twitching

Hydrochlorothiazide:

• Frequency not reported: Muscle spasm

Olmesartan:

• Common (1% to 10%): Arthritis, back pain, skeletal pain, creatine phosphokinase increased
• Uncommon (0.1% to 1%): Myalgia, arthralgia
• Postmarketing reports: Rhabdomyolysis^[Ref]

Respiratory

• Common (1% to 10%): Nasopharyngitis, upper respiratory tract infection
• Uncommon (0.1% to 1%): Cough, dyspnea

Amlodipine:

• Common (1% to 10%): Dyspnea
• Uncommon (0.1% to 1%): Epistaxis
• Rare (less than 0.1%): Coughing, rhinitis

Hydrochlorothiazide:

• Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema

Olmesartan:

• Common (1% to 10%): Bronchitis, cough, pharyngitis, rhinitis, sinusitis^[Ref]

Other

• Common (1% to 10%): Fatigue, peripheral edema
• Uncommon (0.1% to 1%): Asthenia
• Rare (less than 0.1%): Face edema

Amlodipine:

• Very common (10% or more): Edema (up to 10.8%)
• Common (1% to 10%): Fatigue, asthenia
• Uncommon (0.1% to 1%): Malaise, pain, gynecomastia, chest pain

Hydrochlorothiazide:

• Frequency not reported: Weakness, fever

Olmesartan:

• Common (1% to 10%): Chest pain, fatigue, influenza-like symptoms, pain, peripheral edema
• Postmarketing reports: Asthenia, malaise^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection
• Uncommon (0.1% to 1%): Pollakiuria, erectile dysfunction

Amlodipine:

• Common (1% to 10%): Male sexual dysfunction
• Uncommon (0.1% to 1%): Micturition frequency, micturition disorder, nocturia, female sexual dysfunction
• Rare (less than 0.1%): Dysuria, polyuria

Hydrochlorothiazide:

• Frequency not reported: Glycosuria

Olmesartan:

• Common (1% to 10%): Hematuria, urinary tract infection^[Ref]

Cardiovascular

• Uncommon (0.1% to 1%): Palpitations, tachycardia, hypotension, orthostatic hypotension

Amlodipine:

• Common (1% to 10%): Flushing, palpitation
• Uncommon (0.1% to 1%): Hypotension, peripheral ischemia, tachycardia, postural hypotension, hot flushes, vasculitis, arrhythmia, bradycardia
• Rare (less than 0.1%): Cardiac failure, pulse irregularity, extrasystoles
• Frequency not reported: Arrhythmia, myocardial infarction

Hydrochlorothiazide:

• Frequency not reported: Cardiac arrhythmias, vasculitis, postural hypotension

Olmesartan:

• Uncommon (0.1% to 1%): Angina pectoris, tachycardia
• Rare (less than 0.1%): Hypotension^[Ref]

Metabolic

• Uncommon (0.1% to 1%): Hyperkalemia, blood potassium decreased

Amlodipine:

• Uncommon (0.1% to 1%): Weight gain, anorexia, thirst, hyperglycemia, weight decrease
• Rare (less than 0.1%): Increased appetite

Hydrochlorothiazide:

• Frequency not reported: Anorexia, loss of appetite, hyperglycemia, hyperuricemia, electrolyte imbalance, hyponatremia, hypokalemia, cholesterol increased, triglycerides increased

Olmesartan:

• Common (1% to 10%): Hypertriglyceridemia, hyperuricemia, hyperglycemia
• Rare (less than 0.1%): Hyperkalemia^[Ref]

Renal

• Common (1% to 10%): Renal function impaired
• Uncommon (0.1% to 1%): Blood creatinine increased, blood uric acid increased

Hydrochlorothiazide:

• Frequency not reported: Renal failure, renal dysfunction, interstitial nephritis

Olmesartan:

• Postmarketing reports: Acute renal failure, blood creatinine increased^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Rash
• Rare (less than 0.1%): Urticaria

Amlodipine:

• Common (1% to 10%): Pruritus, rash
• Uncommon (0.1% to 1%): Alopecia, pruritus, purpura, rash, sweating increased, angioedema, rash erythematous, rash maculopapular, erythema multiforme
• Rare (less than 0.1%): Skin discoloration, urticaria, skin dryness, dermatitis, cold and clammy skin

Hydrochlorothiazide:

• Frequency not reported: Purpura, photosensitivity, urticaria, Stevens-Johnson syndrome, toxic epidermal necrolysis, rash, cutaneous lupus erythematosus-like reactions, reactivation of cutaneous lupus, erythematosus, cutaneous vasculitis, erythema multiforme, exfoliative dermatitis

Olmesartan:

• Uncommon (0.1% to 1%): Rash
• Postmarketing reports: Angioedema, alopecia, pruritus, urticaria^[Ref]

Hepatic

• Uncommon (0.1% to 1%): GGT increased

Amlodipine:

• Postmarketing reports: Hepatic enzymes increased, hepatitis, jaundice

Hydrochlorothiazide:

• Frequency not reported: Intrahepatic cholestatic jaundice

Olmesartan:

• Common (1% to 10%): Hepatic enzymes increased^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Libido decreased

Amlodipine:

• Uncommon (0.1% to 1%): Depression, insomnia, mood changes, nervousness, abnormal dreams, anxiety, depersonalization
• Rare (less than 0.1%): Apathy, agitation

Hydrochlorothiazide:

• Frequency not reported: Restlessness, sleep disturbances, depression^[Ref]

Immunologic

• Rare (less than 0.1%): Drug hypersensitivity

Amlodipine:

• Uncommon (0.1% to 1%): Allergic reactions

Hydrochlorothiazide:

• Frequency not reported: Anaphylactic reactions

Olmesartan:

• Postmarketing reports: Anaphylactic reactions^[Ref]

Ocular

Amlodipine:

• Uncommon (0.1% to 1%): Abnormal vision, conjunctivitis, diplopia, eye pain
• Rare (less than 0.1%): Xerophthalmia, abnormal visual accommodation

Hydrochlorothiazide:

• Frequency not reported: Transient blurred vision, xanthopsia^[Ref]

Hematologic

Amlodipine:

• Uncommon (0.1% to 1%): Leukopenia, thrombocytopenia

Hydrochlorothiazide:

• Frequency not reported: Aplastic anemia, neutropenia/agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia, bone marrow depression^[Ref]

Further information

Amlodipine/hydrochlorothiazide/olmesartan side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer