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Aldoril 15 Side Effects

Generic name: hydrochlorothiazide / methyldopa

Medically reviewed by Drugs.com. Last updated on Oct 29, 2023.

Note: This document contains side effect information about hydrochlorothiazide / methyldopa. Some dosage forms listed on this page may not apply to the brand name Aldoril 15.

Applies to hydrochlorothiazide / methyldopa: oral tablet.

Serious side effects of Aldoril 15

Along with its needed effects, hydrochlorothiazide/methyldopa may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydrochlorothiazide / methyldopa:

Rare

Check with your doctor as soon as possible if any of the following side effects occur while taking hydrochlorothiazide / methyldopa:

Signs and symptoms of too much potassium loss

Less common

Rare

Other side effects of Aldoril 15

Some side effects of hydrochlorothiazide / methyldopa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to hydrochlorothiazide / methyldopa: oral tablet.

Cardiovascular

Hydrochlorothiazide:

Frequency not reported: Hypotension, orthostatic hypotension, necrotizing angiitis, vasculitis

Methyldopa:

Frequency not reported: Angina pectoris aggravated, congestive heart failure, prolonged carotid sinus hypersensitivity, orthostatic hypotension, bradycardia, myocarditis, pericarditis, vasculitis[Ref]

Dermatologic

Hydrochlorothiazide:

Frequency not reported: Cutaneous vasculitis, photosensitivity, urticaria, rash, purpura, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, alopecia

Methyldopa:

Frequency not reported: Toxic epidermal necrolysis, rash[Ref]

Gastrointestinal

Hydrochlorothiazide:

Frequency not reported: Pancreatitis, diarrhea, vomiting, sialadenitis, cramping, constipation, gastric irritation, nausea

Methyldopa:

Frequency not reported: Pancreatitis, colitis, vomiting, diarrhea, sialadenitis, sore tongue, black tongue, nausea, constipation, distention, flatus, dry mouth[Ref]

Hematologic

Hydrochlorothiazide:

Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia

Methyldopa:

Frequency not reported: Bone marrow depression, leukopenia, granulocytopenia, thrombocytopenia, hemolytic anemia, Coombs test positive, eosinophilia[Ref]

Nervous system

Hydrochlorothiazide:

Frequency not reported: Vertigo, paresthesias, dizziness, headache

Methyldopa:

Frequency not reported: Sedation, headache, Parkinsonism, Bell's palsy, mental acuity decreased, involuntary choreoathetotic movements, cerebrovascular insufficiency symptoms, dizziness, lightheadedness, paresthesias[Ref]

Hepatic

Hydrochlorothiazide:

Frequency not reported: Intrahepatic cholestatic jaundice

Methyldopa:

Frequency not reported: Liver disorders, hepatitis, jaundice, liver function tests abnormal[Ref]

Other

Hydrochlorothiazide:

Frequency not reported: Weakness, fever

Methyldopa:

Frequency not reported: Asthenia, weakness, edema, drug-related fever, breast enlargement, gynecomastia, lactation[Ref]

Psychiatric

Hydrochlorothiazide:

Frequency not reported: Restlessness

Methyldopa:

Frequency not reported: Psychic disturbances, nightmares, reversible mild psychoses, depression, libido decreased[Ref]

Genitourinary

Hydrochlorothiazide:

Frequency not reported: Glycosuria, impotence

Methyldopa:

Frequency not reported: Amenorrhea, impotence[Ref]

Immunologic

Hydrochlorothiazide:

Frequency not reported: Anaphylactic reactions

Methyldopa:

Frequency not reported: Antinuclear antibody test positive, LE cells, rheumatoid factor[Ref]

Metabolic

Hydrochlorothiazide:

Frequency not reported: Anorexia, electrolyte imbalance, hyperglycemia, hyperuricemia

Methyldopa:

Frequency not reported: Weight gain[Ref]

Musculoskeletal

Hydrochlorothiazide:

Frequency not reported: Muscle spasm

Methyldopa:

Frequency not reported: Lupus-like syndrome, arthralgia, myalgia[Ref]

Renal

Hydrochlorothiazide:

Frequency not reported: Renal failure, renal dysfunction, interstitial nephritis

Methyldopa:

Frequency not reported: BUN increased[Ref]

Respiratory

Hydrochlorothiazide:

Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema

Methyldopa:

Frequency not reported: Nasal stuffiness[Ref]

Endocrine

Methyldopa:

Frequency not reported: Hyperprolactinemia[Ref]

Ocular

Hydrochlorothiazide:

Frequency not reported: Transient blurred vision, xanthopsia[Ref]

References

1. "Product Information. Aldoril 25 (hydrochlorothiazide-methyldopa)." Merck & Co., Inc

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.