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Secukinumab

Generic name: secukinumab (SEK ue KIN ue mab)
Brand name: Cosentyx, Cosentyx Sensoready Pen, Cosentyx Sensoready Pen 2-pack, Cosentyx 2-pack
Dosage forms: subcutaneous solution (150 mg/mL; 75 mg/0.5 mL)
Drug class: Interleukin inhibitors

Medically reviewed by Drugs.com on Aug 24, 2021. Written by Cerner Multum.

What is secukinumab?

Secukinumab is an immunosuppressant that is used to treat moderate to severe plaque psoriasis in adults and children at least 6 years old.

Secukinumab is also used in adults to treat psoriatic arthritis, ankylosing spondylitis, or axial spondyloarthritis.

Secukinumab may also be used for purposes not listed in this medication guide.

Warnings

You may get infections more easily. Call your doctor right away if you have signs of infection such as: fever, chills, sweats, muscle aches, skin sores, stomach pain, diarrhea, burning when you urinate, weight loss, cough, shortness of breath, or a cough with red or pink mucus.

Before taking this medicine

You should not use secukinumab if you are allergic to it.

Tell your doctor if you've had or been exposed to tuberculosis, or if you recently traveled. Some infections are more common in certain parts of the world, and you may have been exposed during travel.

Tell your doctor if you have ever had:

  • an active or chronic infection;

  • inflammatory bowel disease (Crohn's disease or ulcerative colitis);

  • an allergy to latex; or

  • if you currently have signs of infection such as fever, sweats, chills, muscle pain, cough, shortness of breath, cough with bloody mucus, weight loss, skin sores, stomach pain, diarrhea, or painful urination.

Make sure you are current on all vaccines before you start using secukinumab.

Tell your doctor if you are pregnant or breastfeeding.

How should I use secukinumab?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Secukinumab is injected under the skin.

Ask your doctor or pharmacist if you don't understand how to use an injection.

Prepare an injection only when you are ready to give it. You may need to use 2 injections to get your total dose.

Secukinumab should be clear or light-yellow. Call your pharmacist if the medicine looks cloudy, has changed colors, or has particles in it.

Your healthcare provider will show you where to inject secukinumab. Do not inject into the same place two times in a row. Avoid injecting into skin that is hard, red, bruised, swollen, tender, or affected by psoriasis. Do not inject within 2 inches of your navel (belly button).

You may get infections more easily, even serious infections. You will need frequent medical tests.

Do not reuse a needle or syringe. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Keep out of the reach of children and pets.

Store secukinumab in the original container in a refrigerator. Protect from light and do not shake or freeze.

Take the injection pen out of the refrigerator and let it reach room temperature for 15 to 30 minutes before using. Give the injection within 1 hour after removing the medicine from a refrigerator.

You may store an injection pen or a prefilled syringe at room temperature (no higher than 86 degrees F) for up to 4 days. Return the pen or syringe to the refrigerator if not used within 4 days. Throw an injection pen or syringe away if left at room temperature for longer than 4 days.

Throw away a prefilled syringe or injection pen after one use, even if there is still medicine left inside.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of secukinumab.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using secukinumab?

Avoid receiving a "live" vaccine. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles).

Secukinumab side effects

Get emergency medical help if you have signs of an allergic reaction: hives; chest tightness, difficult breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat.

Call your doctor right away if you have signs of infection such as:

  • redness, warmth, or painful sores on your skin;

  • cough, shortness of breath, cough with red or pink mucus;

  • increased urination, burning when you urinate;

  • sores or white patches in your mouth or throat (yeast infection or "thrush");

  • new or worsening diarrhea or stomach pain; or

  • fever, chills, sweating, muscle pain, weight loss.

Further doses may be delayed until your infection clears up.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Secukinumab dosing information

Usual Adult Dose for Plaque Psoriasis:

300 mg subcutaneously at weeks 0, 1, 2, 3, and 4 followed by 300 mg every 4 weeks (each 300 mg dose is given as 2 subcutaneous injections of 150 mg); for some patients, a dose of 150 mg subcutaneously may be acceptable

Use: Moderate to severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy

Usual Adult Dose for Psoriatic Arthritis:

WITH A LOADING DOSE: 150 mg subcutaneously at weeks 0, 1, 2, 3, and 4 and every 4 weeks thereafter
WITHOUT A LOADING DOSE: 150 mg subcutaneously every 4 weeks; if the patient continues to have active psoriatic arthritis, consider increasing the dose to 300 mg subcutaneously every 4 weeks

Comments:
-For psoriatic arthritis patients with coexistent moderate to severe plaque psoriasis, use the dosage for plaque psoriasis.
-This drug may be administered with or without methotrexate.

Use: Active psoriatic arthritis

Usual Adult Dose for Ankylosing Spondylitis:

WITH A LOADING DOSE: 150 mg subcutaneously at weeks 0, 1, 2, 3, and 4 and every 4 weeks thereafter
WITHOUT A LOADING DOSE: 150 mg subcutaneously every 4 weeks

Uses:
-For active ankylosing spondylitis
-For the treatment of active non-radiographic axial spondyloarthritis (nraxSpA) with objective signs of inflammation

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What other drugs will affect secukinumab?

Other drugs may affect secukinumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Frequently asked questions

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.