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Secukinumab

Generic Name: secukinumab (SEK ue KIN ue mab)
Brand Name: Cosentyx, Cosentyx Sensoready Pen

Medically reviewed by Drugs.com on Jul 15, 2019 – Written by Cerner Multum

What is secukinumab?

Secukinumab is an immunosuppressant that is used to treat moderate to severe plaque psoriasis, active psoriatic arthritis, or active ankylosing spondylitis.

Secukinumab may also be used for purposes not listed in this medication guide.

Important Information

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use secukinumab if you are allergic to it.

Secukinumab is not approved for use by anyone younger than 18 years old.

Tell your doctor if you have ever had tuberculosis or if anyone in your household has tuberculosis. Also tell your doctor if you have recently traveled. Tuberculosis and some fungal infections are more common in certain parts of the world, and you may have been exposed during travel.

Before you start treatment with secukinumab, your doctor may perform tests to make sure you do not have tuberculosis or other infections.

Tell your doctor if you have ever had:

  • a chronic infection;

  • Crohn's disease; or

  • if you currently have signs of infection such as fever, chills, muscle pain, cough, trouble breathing, skin sores, stomach pain, diarrhea, weight loss, or painful urination.

Make sure you are current on all vaccines before you begin treatment with secukinumab.

Tell your doctor if you are pregnant or breast-feeding.

How should I use secukinumab?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Secukinumab is injected under the skin. A healthcare provider may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. You may need to use 2 injections to get your total dose. Ask your doctor or pharmacist if you don't understand all instructions.

Your care provider will show you where on your body to inject secukinumab. Do not inject into skin with active psoriasis, or skin that is red, bruised, or tender. Do not inject within 2 inches of your navel (belly button).

Secukinumab should be clear or light-yellow. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

Store secukinumab in the original container in a refrigerator. Protect from light and do not shake or freeze. Take the medicine out of the refrigerator and allow it to reach room temperature for 15 to 30 minutes before injecting your dose. Give the injection within 1 hour after removing the medicine from a refrigerator.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

Each prefilled syringe or injection pen is for one use only. Throw it away after one use, even if there is still medicine left inside.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of secukinumab.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using secukinumab?

Do not receive a "live" vaccine while using secukinumab. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Secukinumab side effects

Get emergency medical help if you have signs of an allergic reaction: hives; chest tightness, difficult breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • redness, warmth, or painful sores on your skin;

  • cough, shortness of breath, cough with red or pink mucus;

  • increased urination, burning when you urinate;

  • sores or white patches in your mouth or throat (yeast infection or "thrush");

  • diarrhea, stomach pain; or

  • fever, chills, sweating, muscle pain, weight loss.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Secukinumab dosing information

Usual Adult Dose for Plaque Psoriasis:

300 mg subcutaneously at weeks 0, 1, 2, 3, and 4 followed by 300 mg every 4 weeks (each 300 mg dose is given as 2 subcutaneous injections of 150 mg); for some patients, a dosage of 150 mg subcutaneously may be acceptable

Use: Moderate to severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy

Usual Adult Dose for Psoriatic Arthritis:

-With a loading dose: 150 mg subcutaneously at weeks 0, 1, 2, 3, and 4 and every 4 weeks thereafter
-Without a loading dose: 150 mg subcutaneously every 4 weeks
-If the patient continues to have active psoriatic arthritis, consider increasing the dose to 300 mg subcutaneously every 4 weeks

Comments:
-For psoriatic arthritis patients with coexistent moderate to severe plaque psoriasis, use the dosage for plaque psoriasis.

Use: Active psoriatic arthritis

Usual Adult Dose for Ankylosing Spondylitis:

-With a loading dose: 150 mg subcutaneously at weeks 0, 1, 2, 3, and 4 and every 4 weeks thereafter
-Without a loading dose: 150 mg subcutaneously every 4 weeks

Use: Active ankylosing spondylitis

What other drugs will affect secukinumab?

Other drugs may affect secukinumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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