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Generic name: pyridoxine (vitamin B6) [ PIR-ih-DOX-een ]
Brand names: Vitamin B6, Vitelle Nestrex, Pyridoxal 5'-Phosphate
Dosage forms: injectable solution (100 mg/mL), oral capsule (pyridoxal 5'-phosphate 50 mg), oral tablet (100 mg; 25 mg; 50 mg; pyridoxal 5'-phosphate 50 mg)
Drug class: Vitamins

Medically reviewed by on Apr 25, 2023. Written by Cerner Multum.

What is pyridoxine?

Pyridoxine is vitamin B6. Vitamins occur naturally in foods such as meat, poultry, nuts, whole grains, bananas, and avocados. Vitamin B6 is important for many processes in the body.

Pyridoxine is used to treat or prevent vitamin B6 deficiency. It is also used to treat a certain type of anemia (lack of red blood cells). Pyridoxine injection is also used to treat some types of seizure in babies.

Pyridoxine taken by mouth (oral) is available without a prescription. Injectable pyridoxine must be given by a healthcare professional.

Pyridoxine may also be used for purposes not listed in this medication guide.

Pyridoxine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Pyridoxine may cause serious side effects. Call your doctor at once if you have:

Common side effects of pyridoxine may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use pyridoxine if you have ever had an allergic reaction to it.

Ask a doctor or pharmacist if it is safe for you to use this medicine if:

To make sure you can safely receive injectable pyridoxine, tell your doctor if you have heart disease or kidney disease.

Ask a doctor before using this medicine if you are pregnant or breast-feeding. Your dose needs may be different. High doses of pyridoxine can harm a nursing baby.

Do not give this medicine to a child without medical advice.

How should I use pyridoxine?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Pyridoxine tablets are taken by mouth. Injectable pyridoxine is injected into a muscle or into a vein through an IV. You may be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.

The recommended dietary allowance of pyridoxine increases with age. Follow your healthcare provider's instructions. You may also consult the Office of Dietary Supplements of the National Institutes of Health, or the U.S. Department of Agriculture (USDA) Nutrient Database (formerly "Recommended Daily Allowances") listings for more information.

Pyridoxine may be only part of a complete program of treatment that also includes a special diet. Follow the diet plan created for you by your doctor or nutrition counselor. Get familiar with the list of foods you should eat or avoid to help control your condition.

Store at room temperature away from moisture and heat.

Pyridoxine dosing information

Usual Adult Dose for Drug Induced Vitamin/Mineral Deficiency:

Isoniazid induced deficiencies: 100 mg intramuscularly or intravenously once a day followed by a 30 mg maintenance dose daily

Poisoning caused by ingestion of over 10 grams of isoniazid: Give an equal amount of pyridoxine, starting with 4 grams intravenously followed by 1 gram intramuscularly every 30 minutes

Usual Adult Dose for Dietary Supplement:

Dietary deficiency: 10 to 20 mg intramuscularly or intravenously once a day for 3 weeks
-Follow up with an oral multivitamin containing 2 to 5 mg pyridoxine daily for several weeks.
-Correct poor dietary habits; prescribe a well balanced diet.

Recommended dietary allowance of vitamin B6:
18 years, male: 1.3 mg/day
18 years, female: 1.2 mg/day
19 to 50 years (both genders): 1.3 mg/day
51 to 70 years, male: 1.7 mg/day
51 to 70 years, female: 1.5 mg/day
Pregnancy: 1.9 mg/day
Lactation: 2 mg/day

Usual Adult Dose for Seizures:

Vitamin B6 dependency syndrome: Up to 600 mg intramuscularly or intravenously daily, with a daily intake of 30 mg for life

Usual Pediatric Dose for Dietary Supplement:

Adequate intake of vitamin B6:
0 to 6 months: 0.1 mg/day
7 to 12 months: 0.3 mg/day
Estimated adequate intake of vitamin B6:
1 to 3 years: 0.4 mg/day
4 to 8 years: 0.5 mg/day
9 to 13 years: 0.8 mg/day
14 to 18 years, male: 1.1 mg/day
14 to 18 years, female: 1 mg/day

Recommended dietary allowance of vitamin B6:
1 to 3 years: 0.5 mg/day
4 to 8 years: 0.6 mg/day
9 to 13 years: 1 mg/day
14 to 18 years, male: 1.3 mg/day
14 to 18 years, female: 1.2 mg/day

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not Use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using pyridoxine?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect pyridoxine?

Other drugs may interact with pyridoxine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.