Pyridoxine Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 25, 2025.

Applies to pyridoxine: capsule, powder, solution, tablet, tablet extended release.

Serious side effects of pyridoxine

Along with its needed effects, pyridoxine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking pyridoxine:

With large doses

• Clumsiness
• numbness of hands or feet

For healthcare professionals

Applies to pyridoxine: compounding powder, injectable solution, oral capsule, oral tablet.

Nervous system adverse events

• Frequency not reported: Paresthesia, somnolence^[Ref]

The profound sensory loss following treatment with high doses of parenteral pyridoxine may not be reversible.^[Ref]

Metabolic

• Frequency not reported: Low serum folic acid levels^[Ref]

See also:

Further information

Pyridoxine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer