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Pyridoxine Side Effects

Medically reviewed by Last updated on July 2, 2020.

For the Consumer

Applies to pyridoxine: capsule, powder, solution, tablet, tablet extended release

Side effects requiring immediate medical attention

Along with its needed effects, pyridoxine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking pyridoxine:

With large doses

For Healthcare Professionals

Applies to pyridoxine: compounding powder, injectable solution, oral capsule, oral tablet

Nervous system

The profound sensory loss following treatment with high doses of parenteral pyridoxine may not be reversible.[Ref]

Frequency not reported: Paresthesia, somnolence[Ref]


Frequency not reported: Low serum folic acid levels[Ref]


1. "Product Information. Pyridoxine Hydrochloride (pyridoxine)." Mylan Institutional LLC, Rockford, IL.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.