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minocycline

Pronunciation

Generic Name: minocycline (mye no SYE kleen)
Brand Name: Dynacin, Minocin, Minocin PAC, Solodyn, Vectrin, Myrac

What is minocycline?

Minocycline is a tetracycline antibiotic that fights bacteria in the body.

Minocycline is used to treat many different bacterial infections, such as urinary tract infections, respiratory infections, skin infections, severe acne, gonorrhea, tick fever, chlamydia, and others.

Minocycline may also be used for purposes not listed in this medication guide.

What is the most important information I should know about minocycline?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What should I discuss with my healthcare provider before taking minocycline?

You should not take this medicine if you are allergic to minocycline or to similar antibiotics such as demeclocycline, doxycycline, or tetracycline.

If you are using minocycline to treat gonorrhea, your doctor may test you to make sure you do not also have syphilis, another sexually transmitted disease.

To make sure minocycline is safe for you, tell your doctor if you have:

  • liver disease;

  • kidney disease; or

  • asthma or sulfite allergy.

You should not use minocycline if you are pregnant. It could harm the unborn baby or cause permanent tooth discoloration later in life. Tell your doctor right away if you become pregnant during treatment.

Minocycline can make birth control pills less effective. Ask your doctor about using a non hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using minocycline.

Minocycline passes into breast milk and may affect bone and tooth development in a nursing baby. You should not breast-feed while you are taking minocycline.

Do not give this medicine to a child without medical advice. Minocycline can cause permanent yellowing or graying of the teeth in children younger than 8 years old.

How should I take minocycline?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take this medicine with a full glass of water.

You may take minocycline with or without food.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Minocycline will not treat a viral infection such as the flu or a common cold.

If you use this medicine long-term, you may need frequent medical tests.

This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using minocycline.

Store at room temperature away from moisture, heat, and light.

Throw away any minocycline not used before the expiration date on the medicine label. Using expired minocycline can cause damage to your kidneys.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include dizziness, nausea, or vomiting.

What should I avoid while taking minocycline?

This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Avoid exposure to sunlight or tanning beds. Minocycline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

For 2 hours before or after you take minocycline, avoid taking antacids, laxatives, multivitamins, or supplements that contain calcium or iron. These other medicines can make it harder for your body to absorb minocycline.

Minocycline side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • kidney problems--little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath;

  • liver or pancreas problems--nausea, vomiting, upper stomach pain that may spread to your back, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, vision problems, pain behind your eyes;

  • signs of inflammation in your body--swollen glands, flu symptoms, easy bruising or bleeding, severe tingling or numbness, muscle weakness, chest pain, new or worsening cough with fever, trouble breathing; or

  • severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • nausea, diarrhea, loss of appetite;

  • dizziness, spinning sensation;

  • headache;

  • swollen tongue, cough, trouble swallowing;

  • muscle or joint pain;

  • rash; or

  • discoloration of you skin or nails.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Minocycline dosing information

Usual Adult Dose for Bacterial Infection:

IV: 200 mg IV initially followed by 100 mg IV every 12 hours
Maximum dose: 400 mg/24 hours

Oral:
Most infections: 200 mg orally initially followed by 100 mg orally every 12 hours
-Alternative regimen (if more frequent dosing preferred): 100 to 200 mg orally initially followed by 50 mg orally 4 times a day

Uncomplicated urethral, endocervical, or rectal infections due to Chlamydia trachomatis or Ureaplasma urealyticum: 100 mg orally every 12 hours for at least 7 days

Comments:
-With trachoma, infectious agent is not always eliminated (as assessed by immunofluorescence).
-Coadministration with streptomycin recommended for brucellosis.
-For syphilis, the duration of therapy is 10 to 15 days; close follow-up (including laboratory tests) recommended.

Uses:
-For the treatment of the following infections: Rocky Mountain spotted fever, typhus fever, typhus group, Q fever, rickettsialpox, tick fevers due to rickettsiae; respiratory tract infections due to Mycoplasma pneumoniae; lymphogranuloma venereum, trachoma, or inclusion conjunctivitis due to C trachomatis; psittacosis (ornithosis) due to Chlamydophila psittaci; nongonococcal urethritis, endocervical, or rectal infections due to U urealyticum or C trachomatis; relapsing fever due to Borrelia recurrentis; plague due to Yersinia pestis; tularemia due to Francisella tularensis; cholera due to Vibrio cholerae; Campylobacter fetus infections; brucellosis due to Brucella species; bartonellosis due to Bartonella bacilliformis; granuloma inguinale due to Klebsiella granulomatis
-For the treatment of infections due to the following bacteria when bacteriologic testing shows suitable susceptibility to this drug: Escherichia coli; Enterobacter aerogenes; Shigella species; Acinetobacter species; respiratory tract infections due to Haemophilus influenzae; respiratory tract and urinary tract infections due to Klebsiella species; upper respiratory tract infections due to Streptococcus pneumoniae
-When penicillin is contraindicated, as an alternative agent for the treatment of the following infections: Syphilis due to Treponema pallidum subspecies pallidum; yaws due to T pallidum subspecies pertenue; listeriosis due to Listeria monocytogenes; anthrax due to Bacillus anthracis; Vincent's infection due to Fusobacterium fusiforme; actinomycosis due to Actinomyces israelii; clostridial infections
-As adjunctive therapy for: Acute intestinal amebiasis; severe acne

Usual Adult Dose for Acne:

Extended-release formulations:
45 to 49 kg: 45 mg orally once a day
50 to 59 kg: 55 mg orally once a day
60 to 71 kg: 65 mg orally once a day
72 to 84 kg: 80 mg orally once a day
85 to 96 kg: 90 mg orally once a day
97 to 110 kg: 105 mg orally once a day
111 to 125 kg: 115 mg orally once a day
126 to 136 kg: 135 mg orally once a day

Duration of therapy: 12 weeks

Comments:
-Recommended dose is about 1 mg/kg once a day.
-This drug did not show any effect on non-inflammatory acne lesions.
-Safety not established beyond 12 weeks.

Use: To treat only inflammatory lesions of non-nodular moderate to severe acne vulgaris

American Academy of Dermatology (AAD) Recommendations:
Immediate-release formulations: 50 mg orally once to 3 times a day

Comments:
-Recommended as adjunctive treatment of moderate to severe inflammatory acne
-This drug should not be used as monotherapy.
-Use should be limited to the shortest duration possible; reevaluation recommended at 3 to 4 months to minimize resistant bacteria developing.
-Current guidelines should be consulted for additional information.

Usual Adult Dose for Meningitis -- Meningococcal:

200 mg IV initially followed by 100 mg IV every 12 hours
Maximum dose: 400 mg/24 hours

Use: When penicillin is contraindicated, as an alternative agent for the treatment of meningitis due to Neisseria meningitidis

Usual Adult Dose for Meningococcal Meningitis Prophylaxis:

100 mg orally every 12 hours for 5 days

Comments:
-Diagnostic laboratory studies (including serotyping and susceptibility testing) are recommended to establish the carrier state and the appropriate therapy.
-Prophylactic use of this drug is only recommended when risk of meningococcal meningitis is high.

Use: In the treatment of asymptomatic carriers of N meningitidis to eliminate meningococci from the nasopharynx

Usual Adult Dose for Skin or Soft Tissue Infection:

IV: 200 mg IV initially followed by 100 mg IV every 12 hours
Maximum dose: 400 mg/24 hours

Oral:
Infection due to Staphylococcus aureus: 200 mg orally initially followed by 100 mg orally every 12 hours
-Alternative regimen (if more frequent dosing preferred): 100 to 200 mg orally initially followed by 50 mg orally 4 times a day

Infection due to Mycobacterium marinum: 100 mg orally every 12 hours for 6 to 8 weeks

Comments:
-Not the drug of choice for any type of staphylococcal infection
-The optimal dose has not been established to treat M marinum infections; the recommended dose has been successful in limited cases.

Uses: For the treatment of skin and skin structure infections due to S aureus when bacteriologic testing shows suitable susceptibility to this drug; for the treatment of infections due to M marinum

Infectious Diseases Society of America (IDSA) Recommendations: 100 mg orally twice a day

Comments:
-Recommended for skin and soft tissue infections due to methicillin-susceptible and methicillin-resistant S aureus
-After an initial dose of 200 mg, recommended for purulent cellulitis (cellulitis associated with purulent drainage/exudate without a drainable abscess) due to methicillin-resistant S aureus
-Current guidelines should be consulted for additional information.

Usual Adult Dose for Skin and Structure Infection:

IV: 200 mg IV initially followed by 100 mg IV every 12 hours
Maximum dose: 400 mg/24 hours

Oral:
Infection due to Staphylococcus aureus: 200 mg orally initially followed by 100 mg orally every 12 hours
-Alternative regimen (if more frequent dosing preferred): 100 to 200 mg orally initially followed by 50 mg orally 4 times a day

Infection due to Mycobacterium marinum: 100 mg orally every 12 hours for 6 to 8 weeks

Comments:
-Not the drug of choice for any type of staphylococcal infection
-The optimal dose has not been established to treat M marinum infections; the recommended dose has been successful in limited cases.

Uses: For the treatment of skin and skin structure infections due to S aureus when bacteriologic testing shows suitable susceptibility to this drug; for the treatment of infections due to M marinum

Infectious Diseases Society of America (IDSA) Recommendations: 100 mg orally twice a day

Comments:
-Recommended for skin and soft tissue infections due to methicillin-susceptible and methicillin-resistant S aureus
-After an initial dose of 200 mg, recommended for purulent cellulitis (cellulitis associated with purulent drainage/exudate without a drainable abscess) due to methicillin-resistant S aureus
-Current guidelines should be consulted for additional information.

Usual Adult Dose for Chancroid:

200 mg orally initially followed by 100 mg orally every 12 hours
-Alternative regimen (if more frequent dosing preferred): 100 to 200 mg orally initially followed by 50 mg orally 4 times a day

Use: For the treatment of chancroid due to H ducreyi

Usual Adult Dose for Gonococcal Infection -- Uncomplicated:

Urethritis in men: 100 mg orally every 12 hours for 5 days
Infections other than urethritis and anorectal infections in men: 200 mg orally initially followed by 100 mg orally every 12 hours for at least 4 days

Comments:
-For infections other than urethritis and anorectal infections in men, posttherapy cultures are recommended within 2 to 3 days.

Uses: When penicillin is contraindicated, as an alternative agent for the treatment of the following infections: Uncomplicated urethritis in men due to N gonorrhoeae and other gonococcal infections; infection in women due to N gonorrhoeae

Usual Pediatric Dose for Bacterial Infection:

Older than 8 years: 4 mg/kg orally or IV initially followed by 2 mg/kg orally or IV every 12 hours
Maximum dose: 200 mg/dose initially followed by 200 mg/day

Comments:
-With trachoma, infectious agent is not always eliminated (as assessed by immunofluorescence).
-Coadministration with streptomycin recommended for brucellosis.
-For syphilis, the duration of therapy is 10 to 15 days; close follow-up (including laboratory tests) recommended.

Uses:
-For the treatment of the following infections: Rocky Mountain spotted fever, typhus fever, typhus group, Q fever, rickettsialpox, tick fevers due to rickettsiae; respiratory tract infections due to M pneumoniae; lymphogranuloma venereum, trachoma, or inclusion conjunctivitis due to C trachomatis; psittacosis (ornithosis) due to C psittaci; relapsing fever due to B recurrentis; plague due to Y pestis; tularemia due to F tularensis; cholera due to V cholerae; C fetus infections; brucellosis due to Brucella species; bartonellosis due to B bacilliformis; granuloma inguinale due to K granulomatis
-For the treatment of infections due to the following bacteria when bacteriologic testing shows suitable susceptibility to this drug: E coli; E aerogenes; Shigella species; Acinetobacter species; respiratory tract infections due to H influenzae; respiratory tract and urinary tract infections due to Klebsiella species; upper respiratory tract infections due to S pneumoniae
-When penicillin is contraindicated, as an alternative agent for the treatment of the following infections: Syphilis due to T pallidum subspecies pallidum; yaws due to T pallidum subspecies pertenue; listeriosis due to L monocytogenes; anthrax due to B anthracis; Vincent's infection due to F fusiforme; actinomycosis due to A israelii; clostridial infections
-As adjunctive therapy for: Acute intestinal amebiasis; severe acne

American Academy of Pediatrics Recommendations: 2 mg/kg orally or IV twice a day
Maximum dose: 200 mg/day

Comments:
-Routine use only recommended for children 8 years or older.
-Recommended for mild, moderate, or severe infections
-Current guidelines should be consulted for additional information.

Usual Pediatric Dose for Acne:

12 years or older:
Extended-release formulations:
45 to 49 kg: 45 mg orally once a day
50 to 59 kg: 55 mg orally once a day
60 to 71 kg: 65 mg orally once a day
72 to 84 kg: 80 mg orally once a day
85 to 96 kg: 90 mg orally once a day
97 to 110 kg: 105 mg orally once a day
111 to 125 kg: 115 mg orally once a day
126 to 136 kg: 135 mg orally once a day

Duration of therapy: 12 weeks

Comments:
-Recommended dose is about 1 mg/kg once a day.
-This drug did not show any effect on non-inflammatory acne lesions.
-Safety not established beyond 12 weeks.

Use: To treat only inflammatory lesions of non-nodular moderate to severe acne vulgaris

AAD Recommendations:
Immediate-release formulations:
-Children older than 8 years: 4 mg/kg orally initially followed by 2 mg/kg orally every 12 hours

Comments:
-Recommended as adjunctive treatment of moderate to severe inflammatory acne
-This drug should not be used as monotherapy.
-Use should be limited to the shortest duration possible; reevaluation recommended at 3 to 4 months to minimize resistant bacteria developing.
-Current guidelines should be consulted for additional information.

Usual Pediatric Dose for Skin or Soft Tissue Infection:

Older than 8 years: 4 mg/kg orally or IV initially followed by 2 mg/kg orally or IV every 12 hours
Maximum dose: 200 mg/dose initially followed by 200 mg/day

Comments:
-Not the drug of choice for any type of staphylococcal infection

Use: For the treatment of skin and skin structure infections due to S aureus when bacteriologic testing shows suitable susceptibility to this drug

IDSA Recommendations: 4 mg/kg orally initially followed by 2 mg/kg orally every 12 hours
Maximum dose: 200 mg/dose initially followed by 200 mg/day

Comments:
-Recommended for purulent cellulitis (cellulitis associated with purulent drainage/exudate without a drainable abscess) due to methicillin-resistant S aureus
-Current guidelines should be consulted for additional information.

Usual Pediatric Dose for Skin and Structure Infection:

Older than 8 years: 4 mg/kg orally or IV initially followed by 2 mg/kg orally or IV every 12 hours
Maximum dose: 200 mg/dose initially followed by 200 mg/day

Comments:
-Not the drug of choice for any type of staphylococcal infection

Use: For the treatment of skin and skin structure infections due to S aureus when bacteriologic testing shows suitable susceptibility to this drug

IDSA Recommendations: 4 mg/kg orally initially followed by 2 mg/kg orally every 12 hours
Maximum dose: 200 mg/dose initially followed by 200 mg/day

Comments:
-Recommended for purulent cellulitis (cellulitis associated with purulent drainage/exudate without a drainable abscess) due to methicillin-resistant S aureus
-Current guidelines should be consulted for additional information.

What other drugs will affect minocycline?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • isotretinoin;

  • a penicillin antibiotic--amoxicillin, ampicillin, dicloxacillin, oxacillin, penicillin, ticarcillin, Amoxil, Moxatag, Augmentin, Principen, and others;

  • a blood thinner--warfarin, Coumadin, Jantoven; or

  • ergot medicine--dihydroergotamine, ergotamine, ergonovine, methylergonovine.

This list is not complete. Other drugs may interact with minocycline, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about minocycline.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 13.01.

Last reviewed: April 09, 2015
Date modified: June 01, 2017

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