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oxacillin (injection)

Generic Name: oxacillin (injection) (ox a SIL in)
Brand Name: Oxacillin Sodium ADD-Vantage, Bactocill

What is oxacillin?

Oxacillin is a penicillin antibiotic that fights bacteria in the body.

Oxacillin is used to treat many different types of infections caused by staphylococcus (also called "staph" infection).

Oxacillin may also be used for purposes not listed in this medication guide.

What is the most important information I should know about oxacillin?

You should not use this medicine if you are allergic to oxacillin or to any other penicillin antibiotic.

What should I discuss with my healthcare provider before using oxacillin?

You should not use this medicine if you are allergic to oxacillin or to any other penicillin antibiotic, such as:

  • amoxicillin, Augmentin;

  • ampicillin;

  • carbenicillin;

  • dicloxacillin; or

  • penicillin.

To make sure oxacillin is safe for you, tell your doctor if you have:

  • asthma;

  • kidney disease;

  • liver disease; or

  • a history of any type of allergy.

Oxacillin injection is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant.

Oxacillin can make birth control pills less effective. Ask your doctor about using a non-hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy.

Oxacillin can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How is oxacillin given?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Oxacillin is injected into a vein through an IV. You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.

You may need to use oxacillin injection for 14 days or longer if your infection is severe. Follow your doctor's dosing instructions carefully.

You may need to keep using oxacillin for up to 48 hours after lab tests show that your infection has cleared.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Oxacillin will not treat a viral infection such as the flu or a common cold.

Pay close attention to the expiration date on your medicine label or IV bag. Do not use the medicine if the expiration date has passed. Call your pharmacist for new medicine.

Your doctor may change your medication if your lab (cultures) tests show that your infection is not caused by staphylococcus.

While using oxacillin, you may need frequent blood tests.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking oxacillin?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Oxacillin side effects

Get emergency medical help if you have signs of an allergic reaction: hives, itching; wheezing, difficult breathing; feeling light-headed; swelling of your face, lips, tongue, or throat.

An allergic reaction to oxacillin can occur right after you use the medicine, or you may have a delayed reaction.

An immediate allergic reaction can occur within 48 hours after you use oxacillin, and may cause fever with an itchy skin rash.

A delayed reaction may occur past 48 hours and up to 4 weeks after you use oxacillin. Symptoms of a delayed reaction may include fever with swollen glands, rash or itching, joint pain, stomach pain, and a general ill feeling.

Call your doctor or seek medical attention if you think you may be having an allergic reaction. Also call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;

  • nausea, vomiting;

  • bruising or swelling around the IV needle;

  • kidney problems--little or no urination, painful or difficult urination, red or pink urine;

  • liver problems--nausea, upper stomach pain, itching, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

  • low white blood cell counts--fever, chills, sore throat, swollen gums, mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing.

Common side effects may include:

  • nausea, upset stomach, vomiting, mild diarrhea;

  • vaginal itching or discharge;

  • swollen, black, or "hairy" tongue; or

  • thrush (white patches or inside your mouth or throat).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side effects (in more detail)

Oxacillin dosing information

Usual Adult Dose for Bacterial Infection:

Manufacturer Recommendations:
Mild to moderate infections: 250 to 500 mg IV or IM every 4 to 6 hours
Severe infections: 1 g IV or IM every 4 to 6 hours

Duration of therapy: Therapy should continue for at least 14 days in severe staphylococcal infections. Therapy should continue for at least 48 hours after patient is afebrile, asymptomatic, and has negative cultures. Endocarditis and osteomyelitis may require a longer duration of therapy.

Approved indication: Treatment of infections caused by susceptible penicillinase-producing staphylococci

Usual Adult Dose for Endocarditis:

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

American Heart Association (AHA) recommendations:
Native valve endocarditis due to staphylococci: 2 g IV every 4 hours or 3 g IV every 6 hours (total 12 g/day)

Duration of therapy:
Complicated right-sided infective endocarditis (IE), left-sided IE: 6 weeks
Uncomplicated right-sided IE: 2 weeks

Comments:
-With optional addition of gentamicin 3 mg/kg/day IV or IM in 2 or 3 equally divided doses for 3 to 5 days.
-Refer to current published guidelines for detailed recommendations.

Prosthetic valve endocarditis due to staphylococci: 2 g IV every 4 hours (total 12 g/day)
Duration of therapy: 6 weeks or longer

Comments:
-Plus rifampin 300 mg IV or orally every 8 hours for 6 weeks or longer.
-Plus gentamicin 3 mg/kg/day IV or IM in 2 or 3 equally divided doses for 2 weeks.
-Refer to current published guidelines for detailed recommendations.

Usual Adult Dose for Joint Infection:

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 2 g IV or IM every 4 to 6 hours
Duration of therapy: 3 to 4 weeks, depending on the nature and severity of the infection. Longer therapy, for 6 weeks or longer, may be required for prosthetic joint infections.
Comments: A third-generation cephalosporin, ciprofloxacin, and/or rifampin should be added, depending on the results of the Gram stain.

Usual Adult Dose for Meningitis:

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 2 g IV or IM every 4 hours
Duration of therapy: 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Osteomyelitis:

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 1.5 to 2 g IV every 4 hours
Duration of therapy: In general, treatment of acute or chronic osteomyelitis should continue for 3 to 8 weeks followed by treatment with an oral penicillinase-resistant penicillin. Parenteral penicillinase-resistant therapy for 5 to 28 days followed by oral penicillinase-resistant penicillin for 3 to 6 weeks has also been effective for acute osteomyelitis.

Usual Adult Dose for Pneumonia:

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 2 g IV or IM every 4 hours
Duration of therapy: Therapy should continue for 7 to 10 days if pneumococcus pneumonia is suspected and up to 21 days if other organisms are responsible.

Usual Adult Dose for Septicemia:

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 2 g IV or IM every 4 to 6 hours
Duration of therapy: 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Sinusitis:

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 1 to 1.5 g IV or IM every 4 to 6 hours
Duration of therapy: 10 to 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Skin or Soft Tissue Infection:

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 1 to 1.5 g IV or IM every 4 to 6 hours
Duration of therapy: 7 days, or for 3 days after acute inflammation resolves, depending on the nature and severity of the infection.

Usual Pediatric Dose for Bacterial Infection:

Manufacturer Recommendations:
Premature and neonates: 25 mg/kg/day IV or IM

Infants and children weighing less than 40 kg:
Mild to moderate infections: 12.5 mg/kg IV or IM every 6 hours
Severe infections: 100 mg/kg/day IV or IM in equally divided doses every 4 to 6 hours

Children weighing 40 kg or more:
Mild to moderate infections: 250 to 500 mg IV or IM every 4 to 6 hours
Severe infections: 1 g IV or IM every 4 to 6 hours

Duration of therapy: Therapy should continue for at least 14 days in severe staphylococcal infections. Therapy should continue for at least 48 hours after patient is afebrile, asymptomatic, and has negative cultures. Endocarditis and osteomyelitis may require a longer duration of therapy.

Approved indication: Treatment of infections caused by susceptible penicillinase-producing staphylococci

American Academy of Pediatrics Recommendations:
Less than 1 week:
Less than 1200 g: 25 mg/kg IV or IM every 12 hours
1200 to 2000 g: 25 to 50 mg/kg IV or IM every 12 hours
Greater than 2000 g: 25 to 50 mg/kg IV or IM every 8 hours

1 to 4 weeks:
Less than 1200 g: 25 mg/kg IV or IM every 12 hours
1200 to 2000 g: 25 to 50 mg/kg IV or IM every 8 hours
Greater than 2000 g: 25 to 50 mg/kg IV or IM every 6 hours

1 month or older:
Mild to moderate infections: 100 to 150 mg/kg/day IV or IM in 4 divided doses
Severe infections: 150 to 200 mg/kg/day IV or IM in 4 divided doses

Maximum dose: 12 g/day

Usual Pediatric Dose for Endocarditis:

Manufacturer Recommendations: See Usual Pediatric Dose (Bacterial Infection)

AHA recommendations:
Native valve endocarditis due to staphylococci: 200 mg/kg/day IV in 4 to 6 equally divided doses
Maximum dose: 12 g/day

Duration of therapy:
Complicated right-sided IE, left-sided IE: 6 weeks
Uncomplicated right-sided IE: 2 weeks

Comments:
-With optional addition of gentamicin 1 mg/kg IV or IM every 8 hours for 3 to 5 days.
-Refer to current published guidelines for detailed recommendations.

Prosthetic valve endocarditis due to staphylococci: 200 mg/kg/day IV in 4 to 6 equally divided doses
Maximum dose: 12 g/day
Duration of therapy: 6 weeks or longer

Comments:
-Plus rifampin 20 mg/kg/day IV or orally in 3 equally divided doses for 6 weeks or longer.
-Plus gentamicin 1 mg/kg IV or IM every 8 hours for 2 weeks.
-Refer to current published guidelines for detailed recommendations.

What other drugs will affect oxacillin?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • probenecid; or

  • tetracycline.

This list is not complete. Other drugs may interact with oxacillin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about oxacillin.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 4.04.

Date modified: November 15, 2017
Last reviewed: December 28, 2016

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