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Generic name: lusutrombopag [ LOO-soo-TROM-boe-pag ]
Brand name: Mulpleta
Dosage form: oral tablet (3 mg)
Drug class: Platelet-stimulating agents

Medically reviewed by on Sep 7, 2022. Written by Cerner Multum.

What is lusutrombopag?

Lusutrombopag is a man-made form of a protein that increases production of platelets (blood-clotting cells) in your body. Lusutrombopag can lower the risk of bleeding by increasing platelets in your blood.

Lusutrombopag is used to treat thrombocytopenia (a lack of platelets in the blood) in adults with chronic liver disease who are scheduled to undergo a medical procedure.

Lusutrombopag is not a cure for thrombocytopenia and it will not make your platelet counts normal.

Lusutrombopag may also be used for purposes not listed in this medication guide.


Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use lusutrombopag if you are allergic to it.

Tell your doctor if you have ever had:

  • a blood clot; or

  • a bleeding or blood clotting disorder other than thrombocytopenia.

It is not known whether lusutrombopag will harm an unborn baby. Tell your doctor if you are pregnant.

It is not safe to breast-feed a baby while you are using this medicine. Also do not breast-feed for at least 28 days after your last dose.

How should I take lusutrombopag?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Lusutrombopag is usually taken once daily for 7 days, beginning 8 to 14 days before your procedure.

You may take lusutrombopag with or without food.

Carefully follow your doctor's dosing instructions about the timing of this medication and your procedure.

Store at room temperature away from moisture and heat. Keep each tablet in the foil blister pack until you are ready to take a dose.

What happens if I miss a dose?

Take the missed dose on the same day you remember it. Take your next dose at the regular time and stay on your once-daily schedule. Do not use 2 doses in one day.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking lusutrombopag?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Lusutrombopag side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

You could develop a blood clot if your platelet count gets too high while you are taking lusutrombopag. Call your doctor or get emergency medical help if you have:

  • sudden numbness or weakness (especially on one side of the body);

  • problems with vision or speech;

  • swelling or redness in an arm or leg;

  • fever, chills;

  • stomach pain (upper right side), vomiting;

  • jaundice (yellowing of the skin or eyes); or

  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Common side effects of lusutrombopag may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Lusutrombopag dosing information

Usual Adult Dose for Thrombocytopenia:

3 mg orally once a day starting 8 to 14 days prior to a scheduled procedure

Duration of therapy: 7 days

Comments: Patients should undergo their procedure 2 to 8 days after the last dose.

Use: Treatment of thrombocytopenia in patients with chronic liver disease who are scheduled to undergo a procedure.

What other drugs will affect lusutrombopag?

Other drugs may affect lusutrombopag, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Frequently asked questions

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.