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Generic Name: lusutrombopag
Dosage Form: Tablets
Date of Approval: July 31, 2018
Company: Shionogi Inc.

Treatment for: Thrombocytopenia

Medically reviewed on Jul 31, 2018

FDA Approves Mulpleta

The U.S. Food and Drug Administration (FDA) has approved Mulpleta (lusutrombopag), a thrombopoietin (TPO) receptor agonist for the treatment of thrombocytopenia in patients with chronic liver disease who are scheduled to undergo a medical or dental procedure.

Patient Information

Read this Medication Guide before you start treatment and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or treatment.

What is Mulpleta?

Mulpleta is a prescription medicine used to treat low platelet count (thrombocytopenia) in adults with chronic liver disease who are scheduled to have a procedure.

Mulpleta is not used to make platelet count normal in people with chronic liver disease.

It is not known if this medicine is safe and effective in children.

Before taking Mulpleta

Before taking Mulpleta, tell your healthcare provider about all of your medical conditions, including if you:

  • have a blood clot or have had a history of a blood clot.
  • have any blood clotting problems, other than thrombocytopenia.
  • are pregnant or plan to become pregnant. Mulpleta may harm your baby.
  • are breastfeeding or plan to breastfeed. It is not known if Mulpleta passes into your breast milk. Do not breastfeed during your treatment, and for at least 28 days after your last dose. Talk to your healthcare provider about the best way to feed your baby during your treatment.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How should I take Mulpleta?

  • Take Mulpleta tablets exactly as your healthcare provider tells you to take it.
  • Your healthcare provider will tell you when to start treatment.
  • Take the tablets one time each day for 7 days.
  • The tablets may be taken with or without food.
  • If you miss a dose, take the missed dose as soon as possible on the same day and return to your normal schedule the following day.
  • If you take too much, or overdose, call your healthcare provider or go to the nearest hospital emergency room right away.
  • Your healthcare provider will check your platelet count before you start treatment, and before your procedure.

Mulpleta side effects

Mulpleta may cause serious side effects, including:

  • Blood clots, including blood clots in the liver, may happen in people with chronic liver disease and who take Mulpleta. You may have an increased risk of blood clots if you have certain blood clotting conditions.

The most common side effect is headache.

These are not all of the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store Mulpleta?

  • Store Mulpleta at room temperature between 68°F and 77°F (20°C to 25°C).
  • Mulpleta comes in a child-resistant blister pack. Keep Mulpleta in the packaging that it comes in.

Keep all medicines out of the reach of children and pets.

General information about the safe and effective use of Mulpleta.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use this medicine for a condition for which it was not prescribed. Do not give it to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information that is written for healthcare professionals.

What are the ingredients of Mulpleta?

Active ingredient: lusutrombopag.

Inactive ingredients: D-mannitol, microcrystalline cellulose, magnesium oxide, sodium lauryl sulfate, hydroxypropyl cellulose, carboxymethylcellulose calcium, magnesium stearate, hypromellose, triethyl citrate, titanium dioxide, red ferric oxide, and talc.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.