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Lusutrombopag Side Effects

Medically reviewed by Last updated on Jul 4, 2022.

For the Consumer

Applies to lusutrombopag: oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, lusutrombopag may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lusutrombopag:

More common

Incidence not known

  • Difficulty breathing
  • pain in the chest, groin, or legs, especially the calves
  • severe, sudden headache
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • vision changes

Side effects not requiring immediate medical attention

Some side effects of lusutrombopag may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Headache

For Healthcare Professionals

Applies to lusutrombopag: oral tablet


The most common adverse reaction was headache.[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]


Common (1% to 10%): Portal vein thrombosis[Ref]

Frequently asked questions


1. "Product Information. Mulpleta (lusutrombopag)." Shionogi USA Inc (2018):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.