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Lusutrombopag (Oral)

Generic Name: lusutrombopag (loo-soo-TROM-boe-pag)

Medically reviewed by Drugs.com. Last updated on July 5, 2020.

Commonly used brand name(s)

In the U.S.

  • Mulpleta

Available Dosage Forms:

  • Tablet

Therapeutic Class: Hematopoietic

Pharmacologic Class: Thrombopoietin Receptor Agonist

Uses for lusutrombopag

Lusutrombopag is used to treat thrombocytopenia (low platelets in the blood) in adults with chronic liver disease who are scheduled to have a medical or dental procedure. It works by stimulating the bone marrow to produce more platelets.

Lusutrombopag is available only with your doctor's prescription.

Before using lusutrombopag

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For lusutrombopag, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to lusutrombopag or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of lusutrombopag in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of lusutrombopag in the elderly.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of lusutrombopag. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blood clots, history of—Use with caution. May make these conditions worse.
  • Blood clotting disorder (eg, antithrombin deficiency, Factor V Leiden, prothrombin 20210A or, Protein C or S deficiency)—Use with caution. May increase risk for blood clotting problems (eg, thromboembolism).

Proper use of lusutrombopag

Take lusutrombopag only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Lusutrombopag comes with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions.

You may take lusutrombopag with or without food.

You should begin using lusutrombopag 8 to 14 days before your scheduled procedure. You may have your medical or dental procedure 2 to 8 days after the last dose of lusutrombopag.

Dosing

The dose of lusutrombopag will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of lusutrombopag. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage forms (tablets):
    • For thrombocytopenia:
      • Adults—3 milligrams (mg) taken once a day with for 7 days.
      • Children—Use and dose must be determined by your doctor.

Missed dose

If you miss a dose of lusutrombopag, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions while using lusutrombopag

It is very important that your doctor check your progress at regular visits to make sure lusutrombopag is working properly. Blood tests will be needed while you are using lusutrombopag.

Blood clotting problems may occur while you are using lusutrombopag. Check with your doctor right away if you have pain, swelling, or tenderness in your leg, or pain in your chest.

Lusutrombopag side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  • Blood in the stool
  • stomach pain
  • vomiting blood

Incidence not known

  • Difficulty breathing
  • pain in the chest, groin, or legs, especially the calves
  • severe, sudden headache
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • vision changes

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Headache

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.