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Levalbuterol inhalation

Generic name: levalbuterol inhalation [ leh-val-BYOO-ter-all ]
Brand names: Xopenex, Xopenex HFA, Xopenex Concentrate
Dosage forms: inhalation aerosol (45 mcg/inh), inhalation solution (0.31 mg/3 mL; 0.63 mg/3 mL; 1.25 mg/0.5 mL; 1.25 mg/3 mL)
Drug class: Adrenergic bronchodilators

Medically reviewed by Drugs.com on Aug 11, 2023. Written by Cerner Multum.

What is levalbuterol inhalation?

Levalbuterol is a short-acting bronchodilator that relaxes muscles in the airways and increases air flow to the lungs.

Levalbuterol inhalation is used to treat or prevent asthma attacks in adults and children who are at least 4 years old.

Levalbuterol inhalation may also be used for purposes not listed in this medication guide.

Levalbuterol inhalation side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Levalbuterol inhalation may cause serious side effects. Call your doctor at once if you have:

Common side effects of levalbuterol inhalation may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Seek medical attention if you think your asthma medications are not working as well.

Before taking this medicine

You should not use levalbuterol inhalation if you are allergic to levalbuterol or albuterol (Accuneb, ProAir, Proventil, Ventolin).

To make sure levalbuterol is safe for you, tell your doctor if you have:

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether levalbuterol inhalation passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

A levalbuterol inhaler should not be given to a child younger than 4 years old. Levalbuterol solution in a nebulizer should not be given to a child younger than 6 years old.

How should I use levalbuterol inhalation?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Any child using levalbuterol inhalation should be supervised by an adult while using this medicine.

Prime the inhaler device before your first use. Pump 4 test sprays into the air, away from your face. Shake the inhaler for at least 5 seconds before each spray. Prime again whenever the inhaler has not been used in longer than 3 days.

To use the inhaler:

Store the levalbuterol inhaler with the mouthpiece down. Keep the inhaler at room temperature away from heat, sunlight, or freezing temperatures. If your inhaler has a dose number indicator on it, throw away the inhaler when the number displays "0" to show that all sprays have been used.

Keep the inhaler canister away from open flame or high heat, such as in a car on a hot day. The canister may explode if it gets too hot. Do not puncture or burn an empty inhaler canister.

Levalbuterol concentrate solution is given with a nebulizer. The concentrate must be mixed with a liquid (diluent) before using it. Ask your pharmacist about which diluent to use and where you can buy it. Be sure you understand how to properly mix the medicine and place it into the nebulizer.

To use the solution with a nebulizer:

Do not use the nebulizer solution if it does not appear clear and colorless.

Store the levalbuterol concentrate vials in the protective foil pouch at room temperature, away from moisture, heat, and light. Keep each vial in the foil pouch until you are ready to prepare a dose in the nebulizer.

Each single-use plastic vial of levalbuterol concentrate is for one use only. Throw away after one use, even if there is still some medicine left in it after inhaling your dose.

Asthma is often treated with a combination of drugs. Use all medications as directed by your doctor. Do not change your doses or medication schedule without your doctor's advice.

Using too much levalbuterol or using it too often can cause life-threatening side effects. Seek medical attention if you think your asthma medications are not working as well. An increased need for medication could be an early sign of a serious asthma attack.

Dupixent, Anoro Ellipta, albuterol, prednisone, azithromycin, methylprednisolone, dexamethasone, Symbicort, ipratropium, Ventolin HFA

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

Use levalbuterol inhalation regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of levalbuterol can be fatal.

What should I avoid while using levalbuterol inhalation?

Avoid situations that may make your condition worse such as exercising in cold, dry air; smoking; breathing in dust; and exposure to allergens such as pet fur.

What other drugs will affect levalbuterol inhalation?

Tell your doctor if you have used an MAO inhibitor in the past 14 days. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor about all your current medicines and any you start or stop using, especially:

This list is not complete. Other drugs may interact with levalbuterol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Does levalbuterol interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Popular FAQ

Can asthma inhalers cause a sore throat?

Yes, some asthma inhalers can cause a sore throat, irritation and hoarseness due to the active ingredient, like a corticosteroid, depositing on the back of your throat. Using a spacer device, rinsing your mouth with water after your dose and improving your inhaler technique can help reduce the chance for a sore throat. Continue reading

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.