Dextromethorphan, diphenhydramine, and phenylephrine
Generic name: dextromethorphan, diphenhydramine, and phenylephrine [ DEX-troe-me-THOR-fan, DYE-fen-HYE-dra-meen, and-FEN-il-EFF-rin ]
Brand names: Dytan-DM, Triaminic Day Time Night Time Cold & Cough, Duratuss AC 12, D-Tann DM, Triaminic Day Time Night Time Cold and Cough
Dosage forms: oral liquid (varying strength); oral suspension, extended release (75 mg-25 mg-7.5 mg/5 mL)
Drug class: Upper respiratory combinations
What is dextromethorphan, diphenhydramine, and phenylephrine?
Dextromethorphan, diphenhydramine, and phenylephrine may also be used for purposes not listed in this medication guide.
Use this medicine exactly as directed. Taking too much diphenhydramine can lead to serious heart problems, seizures, coma, or death.
Do not use this medicine to make a child sleepy. Ask a doctor before giving the medicine to a child younger than 4 years old.
Ask a doctor or pharmacist before using any other medicine that may contain diphenhydramine. Taking too much of this medicine can lead to a fatal overdose.
Before taking this medicine
Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
Ask a doctor or pharmacist if this medicine is safe to use if you have ever had:
a cough with mucus;
an enlarged prostate or urination problems;
high blood pressure, heart disease;
a thyroid disorder;
This medicine may contain phenylalanine. Check the medication label if you have phenylketonuria (PKU).
Ask a doctor before using this medicine if you are pregnant or breastfeeding.
How should I take dextromethorphan, diphenhydramine, and phenylephrine?
Use exactly as directed on the label, or as prescribed by your doctor. Cold or cough medicine is only for short-term use until your symptoms clear up.
Do not take more of this medicine than is recommended. Taking too much diphenhydramine can lead to serious heart problems, seizures, coma, or death.
Always follow directions on the medicine label about giving this medicine to a child. Do not use the medicine only to make a child sleepy. Death can occur from the misuse of antihistamines in very young children.
Ask a doctor before giving the medicine to a child younger than 4 years old.
Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Since dextromethorphan, diphenhydramine, and phenylephrine is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal.
Overdose symptoms may include vomiting, confusion, severe drowsiness, ringing in your ears, no urination, very dry eyes and mouth, dilated pupils, fast heartbeats, tremor, agitation, hallucinations, or seizure.
What should I avoid while taking dextromethorphan, diphenhydramine, and phenylephrine?
Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.
Ask a doctor or pharmacist before using any other medicine that may contain diphenhydramine. This includes medicines for sleep, cold/allergy symptoms, or anti-itch medicine used on the skin. Using too much diphenhydramine may lead to a fatal overdose.
Drinking alcohol with this medicine can cause side effects.
dextromethorphan, diphenhydramine, and phenylephrine side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using this medicine and call your doctor at once if you have:
painful or difficult urination;
fast, pounding, or uneven heartbeats;
confusion, anxiety, irritability, tremors;
a seizure; or
problems with balance or speech.
Common side effects may include:
dizziness, drowsiness, headache;
blurred vision, dry eyes;
dry mouth, nose, or throat;
tiredness, trouble sleeping.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect dextromethorphan, diphenhydramine, and phenylephrine?
Ask a doctor or pharmacist before using dextromethorphan, diphenhydramine, and phenylephrine with any other medicines, especially drugs that can cause drowsiness (such as opioid medication, sleep medicine, a muscle relaxer, or medicine for anxiety or seizures). Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.
More about dextromethorphan / diphenhydramine / phenylephrine
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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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