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Ceftolozane and tazobactam

Generic Name: ceftolozane and tazobactam (sef TOL oh zane and TAZ oh BAK tam)
Brand Name: Zerbaxa

Medically reviewed by on Jan 14, 2019 – Written by Cerner Multum

What is ceftolozane and tazobactam?

Ceftolozane is a cephalosporin antibiotic and tazobactam is a penicillin antibiotic. These medicines fight bacteria in the body.

Ceftolozane and tazobactam is a combination medicine used to treat certain bacterial infections of the stomach or urinary tract.

Ceftolozane and tazobactam may also be used for purposes not listed in this medication guide.

Important Information

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use ceftolozane and tazobactam if you are allergic to ceftolozane or tazobactam, or if you are allergic to similar antibiotics, such as:

To make sure ceftolozane and tazobactam is safe for you, tell your doctor if you have:

  • kidney disease (or if you are on dialysis).

Ceftolozane and tazobactam is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether ceftolozane and tazobactam passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How is ceftolozane and tazobactam given?

This medicine is usually given for 4 to 14 days, depending on the type of infection being treated. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Ceftolozane and tazobactam will not treat a viral infection such as the common cold or flu.

Ceftolozane and tazobactam is injected into a vein through an IV. You may be shown how to use an IV at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Ceftolozane and tazobactam is a powder medicine that must be mixed with a liquid (diluent) before using it. You will then need to dilute this mixture into a solution with another liquid in an IV bag. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.

Each single-use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after preparing your dose.

Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

Store the dry powder medicine in a refrigerator. Do not freeze.

After you mix the powder and diluent, you may store this mixture at room temperature for up to 1 hour before further diluting it.

Medicine mixed in an IV bag must be used within 24 hours if you keep it at room temperature.

Mixed medication in an IV bag can also be stored in the refrigerator for up to 7 days. Do not freeze. Throw away any unused mixture that has not been used within that time.

Do not use the diluted solution if it has changed colors or has particles in it. Call your pharmacist for new medication.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of ceftolozane and tazobactam.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using ceftolozane and tazobactam?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Ceftolozane and tazobactam side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe stomach pain; or

  • diarrhea that is watery or bloody.

Side effects may be more likely in older adults.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ceftolozane and tazobactam dosing information

Usual Adult Dose for Intraabdominal Infection:

1.5 g IV every 8 hours
Duration of therapy: 4 to 14 days

-Metronidazole (500 mg IV every 8 hours) should be used concomitantly.

Use: In combination with metronidazole, for the treatment of complicated intraabdominal infections due to Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, K pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Bacteroides fragilis, Streptococcus anginosus, S constellatus, S salivarius

Usual Adult Dose for Pyelonephritis:

1.5 g IV every 8 hours
Duration of therapy: 7 days

Use: For the treatment of complicated urinary tract infections (including pyelonephritis) due to E coli, K pneumoniae, P mirabilis, P aeruginosa

Usual Adult Dose for Urinary Tract Infection:

1.5 g IV every 8 hours
Duration of therapy: 7 days

Use: For the treatment of complicated urinary tract infections (including pyelonephritis) due to E coli, K pneumoniae, P mirabilis, P aeruginosa

What other drugs will affect ceftolozane and tazobactam?

Other drugs may interact with ceftolozane and tazobactam, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.