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Ceftolozane / tazobactam Pregnancy and Breastfeeding Warnings

Ceftolozane / tazobactam is also known as: Zerbaxa

Ceftolozane / tazobactam Pregnancy Warnings

Ceftolozane: -Animal studies have failed to reveal evidence of teratogenicity. It is not known if it crosses the placenta in animals. There are no controlled data in human pregnancy. Tazobactam: -Animal studies have shown when administered intravenously at 19 times the recommended human dose, there is evidence of maternal but not fetal toxicity. This drug was shown to cross the placenta in rats and reach concentrations in the fetus about 10% of those found in maternal plasma. There are no controlled data in human pregnancy. US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

This drug should be used during pregnancy only if the benefit outweighs the risk to the fetus. US FDA pregnancy category: B

See references

Ceftolozane / tazobactam Breastfeeding Warnings

Caution is recommended. Excreted into human milk: Unknown (ceftolozane, tazobactam) Excreted into animal milk: Data not available (ceftolozane, tazobactam) Comments: The effects in the nursing infant are unknown.

See references

References for pregnancy information

  1. "Product Information. Zerbaxa (ceftolozane-tazobactam)." Cubist Pharmaceuticals Inc, Lexington, MA.

References for breastfeeding information

  1. "Product Information. Zerbaxa (ceftolozane-tazobactam)." Cubist Pharmaceuticals Inc, Lexington, MA.

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