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Ceftolozane / tazobactam Side Effects

For the Consumer

Applies to ceftolozane / tazobactam: intravenous powder for solution, powder iv (infusion)

Along with its needed effects, ceftolozane / tazobactam may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ceftolozane / tazobactam:

More common
  • Fever
Less common
  • Blurred vision
  • confusion
  • convulsions
  • decreased urine
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • pale skin
  • rash
  • sweating
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Rare
  • Abdominal or stomach cramps or pain
  • arm, back, or jaw pain
  • bloating
  • bloody urine
  • chest pain or discomfort
  • chest tightness or heaviness
  • constipation
  • creamy white, curd-like patches in the mouth or throat
  • decreased frequency or amount of urine
  • diarrhea
  • dry, red, hot, or irritated skin
  • fast or irregular heartbeat
  • hives or welts, itching skin
  • increased thirst
  • lower back or side pain
  • pain when eating or swallowing
  • severe constipation
  • severe vomiting
  • swelling of the face, fingers, or lower legs
  • weight gain
Incidence not known
  • Abdominal or stomach tenderness
  • cough
  • difficulty with swallowing
  • dizziness
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • severe abdominal or stomach cramps and pain
  • watery and severe diarrhea, which may also be bloody

Some side effects of ceftolozane / tazobactam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Headache
Less common
  • Acid or sour stomach
  • belching
  • burning feeling in the chest or stomach
  • fear or nervousness
  • heartburn
  • indigestion
  • stomach discomfort or upset
  • trouble sleeping
Rare
  • Flushed, dry skin
  • fruit-like breath odor
  • increased hunger
  • increased urination
  • unexplained weight loss

For Healthcare Professionals

Applies to ceftolozane / tazobactam: intravenous powder for injection

Cardiovascular

Common (1% to 10%): Atrial fibrillation, hypotension,
Uncommon (0.1% to 1%): Tachycardia, angina pectoris[Ref]

Dermatologic

Uncommon (0.1% to 1%): Urticaria[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, diarrhea, constipation, abdominal pain,
Uncommon (0.1% to 1%): Ileus, gastritis, abdominal distension, dyspepsia, flatulence, ileus[Ref]

Hematologic

Common (1% to 10%): Anemia, thrombocytosis[Ref]

Hepatic

Common (1% to 10%): AST/ALT increased[Ref]

Hypersensitivity

Common (1% to 10%): Rash[Ref]

Immunologic

Uncommon (0.1% to 1%): Oropharyngeal candidiasis, fungal urinary tract infection[Ref]

Local

Uncommon (0.1% to 1%): Infusion site reactions[Ref]

Metabolic

Common (1% to 10%): Hypokalemia
Uncommon (0.1% to 1%): Hyperglycemia, hypomagnesemia, hypophosphatemia[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness
Uncommon (0.1% to 1%): Ischemic stroke[Ref]

Other

Common (1% to 10%): Pyrexia
Uncommon (0.1% to 1%): Increased serum gamma-glutamyl transpeptidase (GGT), increased serum alkaline phosphatase, positive Coombs test, venous thrombosis[Ref]

Psychiatric

Common (1 to 10%): Insomnia, anxiety[Ref]

Renal

Uncommon (0.1% to 1%): Renal impairment, renal failure[Ref]

Respiratory

Uncommon (0.1% to 1%): Dyspnea[Ref]

References

1. "Product Information. Zerbaxa (ceftolozane-tazobactam)." Cubist Pharmaceuticals Inc, Lexington, MA.

Some side effects of ceftolozane / tazobactam may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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