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Ceftolozane / Tazobactam Dosage

Medically reviewed on January 15, 2018.

Applies to the following strengths: 1 g-0.5 g

Usual Adult Dose for Intraabdominal Infection

1.5 g IV every 8 hours
Duration of therapy: 4 to 14 days

Comments:
-Metronidazole (500 mg IV every 8 hours) should be used concomitantly.

Use: In combination with metronidazole, for the treatment of complicated intraabdominal infections due to Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, K pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Bacteroides fragilis, Streptococcus anginosus, S constellatus, S salivarius

Usual Adult Dose for Pyelonephritis

1.5 g IV every 8 hours
Duration of therapy: 7 days

Use: For the treatment of complicated urinary tract infections (including pyelonephritis) due to E coli, K pneumoniae, P mirabilis, P aeruginosa

Usual Adult Dose for Urinary Tract Infection

1.5 g IV every 8 hours
Duration of therapy: 7 days

Use: For the treatment of complicated urinary tract infections (including pyelonephritis) due to E coli, K pneumoniae, P mirabilis, P aeruginosa

Renal Dose Adjustments

Estimated CrCl 30 to 50 mL/min: 750 mg IV every 8 hours
Estimated CrCl 15 to 29 mL/min: 375 mg IV every 8 hours

Comments:
-CrCl estimated using the Cockcroft-Gault formula.
-CrCl should be monitored at least daily in patients with changing renal function and dose should be adjusted accordingly.

Liver Dose Adjustments

No adjustment recommended.

Precautions

CONTRAINDICATIONS:
Known serious hypersensitivity to either active component, piperacillin-tazobactam, or other members of the beta-lactam class

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

ESRD on hemodialysis: 750 mg IV as a single loading dose followed by 150 mg IV every 8 hours for remainder of treatment period

Comments:
-On hemodialysis days, dose should be administered at the earliest possible time after completion of dialysis.

Other Comments

1.5 g ceftolozane-tazobactam contains 1 g ceftolozane and 0.5 g tazobactam
750 mg ceftolozane-tazobactam contains 500 mg ceftolozane and 250 mg tazobactam
375 mg ceftolozane-tazobactam contains 250 mg ceftolozane and 125 mg tazobactam
150 mg ceftolozane-tazobactam contains 100 mg ceftolozane and 50 mg tazobactam

Administration advice:
-Administer all doses by IV infusion over 1 hour.
-Duration of therapy should be guided by severity and site of infection and the clinical and bacteriological progress of the patient.

Storage requirements:
-Prior to reconstitution: Store refrigerated at 2C to 8C (36F to 46F); protect from light.
-After reconstitution with appropriate diluent: May hold the reconstituted solution for 1 hour before transfer and dilution in appropriate infusion bag; do not freeze.
-After dilution of reconstituted solutions with appropriate diluents: Prepared infusion bags are stable for 24 hours when stored at room temperature or 7 days when stored refrigerated at 2C to 8C (36F to 46F); do not freeze.

Reconstitution/preparation techniques:
-Must be reconstituted and then diluted; the manufacturer product information should be consulted.

IV compatibility:
-Compatible diluents for reconstitution: Sterile water for injection; 0.9% Sodium Chloride for Injection, USP
-Compatible diluents for dilution: 0.9% Sodium Chloride for Injection, USP; 5% Dextrose Injection, USP
-Compatibility with other agents has not been established; this drug should not be mixed with other agents or physically added to solutions containing other agents.

General:
-The dose is expressed as the total of ceftolozane content plus tazobactam content.
-To reduce the development of drug-resistant organisms and maintain effective therapy, antibiotics should be used only to treat or prevent infections proven or strongly suspected to be caused by susceptible bacteria.
-Culture and susceptibility information should be considered when selecting/modifying antibacterial therapy or, if no data are available, local epidemiology and susceptibility patterns may be considered when selecting empiric therapy.

Monitoring:
-Renal: CrCl in patients with changing renal function (at least daily); renal function in elderly patients

Patient advice:
-Avoid missing doses and complete the entire course of therapy.
-Consult healthcare provider if severe watery or bloody diarrhea develops.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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