Skip to Content

Ceftolozane / Tazobactam Dosage

Applies to the following strength(s): 1 g-0.5 g

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Intraabdominal Infection

Complicated Intra-Abdominal Infections:
1.5 g (ceftolozane 1 g- tazobactam 0.5 g) IV infusion every 8 hours; infuse over 1 hour
Duration of therapy: 4 to 14 days

Complicated Urinary Tract Infections:
1.5 g (ceftolozane 1 g- tazobactam 0.5 g) IV infusion every 8 hours; infuse over 1 hour
Duration of therapy: 7 days

Comments:
-For complicated intra-abdominal infections use in conjunction with metronidazole 500 mg IV every 8 hours.
-Treatment duration should be guided by the severity and site of infection and the patient's clinical and bacteriological progress.

Uses:
-For use in combination with metronidazole for the treatment of complicated intra-abdominal infections caused by E. cloacae, E. coli, K. oxytoca, K. pneumoniae, P. mirabilis, P. aeruginosa, B. fragilis, S. anginosus, S. constellatus, and S. salivarius.
-For the treatment of complicated urinary tract infections, including pyelonephritis, caused by E. coli, K. pneumoniae, P. mirabilis, and P. aeruginosa.

Usual Adult Dose for Urinary Tract Infection

Complicated Intra-Abdominal Infections:
1.5 g (ceftolozane 1 g- tazobactam 0.5 g) IV infusion every 8 hours; infuse over 1 hour
Duration of therapy: 4 to 14 days

Complicated Urinary Tract Infections:
1.5 g (ceftolozane 1 g- tazobactam 0.5 g) IV infusion every 8 hours; infuse over 1 hour
Duration of therapy: 7 days

Comments:
-For complicated intra-abdominal infections use in conjunction with metronidazole 500 mg IV every 8 hours.
-Treatment duration should be guided by the severity and site of infection and the patient's clinical and bacteriological progress.

Uses:
-For use in combination with metronidazole for the treatment of complicated intra-abdominal infections caused by E. cloacae, E. coli, K. oxytoca, K. pneumoniae, P. mirabilis, P. aeruginosa, B. fragilis, S. anginosus, S. constellatus, and S. salivarius.
-For the treatment of complicated urinary tract infections, including pyelonephritis, caused by E. coli, K. pneumoniae, P. mirabilis, and P. aeruginosa.

Renal Dose Adjustments

CrCl 30 to 50 mL/min: 750 mg (ceftolozane 500 mg- tazobactam 250 mg) IV infusion every 8 hours
CrCl 15 to 29 mL/min: 375 mg (ceftolozane 250 mg- tazobactam 125 mg) IV infusion every 8 hours

Comment:
For patients with changing renal function, monitor CrCl at least daily and adjust dose accordingly.

Liver Dose Adjustments

No adjustment recommended.

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

End-stage renal disease (ESRD) on hemodialysis (HD):
Loading dose: 750 mg (ceftolozane 500 mg-tazobactam 250 mg) IV infusion over 1 hour
Maintenance dose: 150 mg (ceftolozane 100 mg-tazobactam 50 mg) IV infusion every 8 hours for remainder of treatment period
Comments: On HD days, administer dose at earliest possible time following completion of dialysis

Other Comments

Administration advice:
-IV infusion over 1 hour

Reconstitution/Preparation techniques:
-Reconstitute vial with 10 mL of sterile water for injection or 0.9% sodium chloride for injection; gently shake to dissolve; the final volume of reconstituted vial will be 11.4 mL
-To prepare drug for infusion, add specified volume to a 100 mL infusion bag containing either 0.9% sodium chloride for injection (NS) or 5% dextrose for injection (D5W).
-For a 1.5 g dose, add 11.4 mL of reconstituted drug; for a 750 mg dose, add 5.7 mL; for a 375 mg dose, add 2.9 mL, for a 150 mg dose, add 1.2 mL

Storage Requirements:
-Prior to use, vials should be stored in refrigerator (2 to 8C or 36 to 46F); protect from light
-Once reconstituted, IV infusion with D5W or NS should be prepared within 1 hour
-Prepared infusion bags are stable for 24 hours at room temperature or 7 days when stored under refrigeration (2 to 8C or 36 to 46F); do not freeze.

IV compatibility: Has not been established; do not mix or add with other IV medications.

General:
-Serious allergic reactions have been reported with use of this drug. Ask patient about any previous hypersensitivity reaction to this medication, other beta-lactams, or allergens.
-Medication should be taken exactly as directed. Skipping doses or not completing full course of therapy may decrease effectiveness of treatment and also increase bacterial resistance for future infections.

Monitoring:
-For patients with changing renal function, monitor CrCl at least daily and adjust dose accordingly.

Patient advice:
-Instruct patient to report frequent watery or bloody diarrhea, as this may be a sign of a more serious intestinal infection.

Hide