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Dobutrex and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with Dobutrex (dobutamine).

Moderate

Dobutamine Caffeine

Moderate Drug Interaction

MONITOR: Coadministration of two or more sympathomimetic agents may increase the risk of adverse effects such as nervousness, irritability, and increased heart rate. Central nervous system (CNS) stimulants, particularly amphetamines, can potentiate the adrenergic response to vasopressors and other sympathomimetic agents. Additive increases in blood pressure and heart rate may occur due to enhanced peripheral sympathetic activity.

MANAGEMENT: Caution is advised if two or more sympathomimetic agents are coadministered. Pulse and blood pressure should be closely monitored.

References (7)
  1. Rosenblatt JE, Lake CR, van Kammen DP, Ziegler MG, Bunney WE Jr (1979) "Interactions of amphetamine, pimozide, and lithium on plasma norepineophrine and dopamine-beta-hydroxylase in schizophrenic patients." Psychiatry Res, 1, p. 45-52
  2. Cavanaugh JH, Griffith JD, Oates JA (1970) "Effect of amphetamine on the pressor response to tyramine: formation of p-hydroxynorephedrine from amphetamine in man." Clin Pharmacol Ther, 11, p. 656
  3. (2001) "Product Information. Adderall (amphetamine-dextroamphetamine)." Shire Richwood Pharmaceutical Company Inc
  4. (2001) "Product Information. Tenuate (diethylpropion)." Aventis Pharmaceuticals
  5. (2001) "Product Information. Sanorex (mazindol)." Novartis Pharmaceuticals
  6. (2001) "Product Information. Focalin (dexmethylphenidate)." Mikart Inc
  7. (2002) "Product Information. Strattera (atomoxetine)." Lilly, Eli and Company

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Major

Dobutamine High Blood Pressure (Hypertension)

Major Potential Hazard, Moderate plausibility

dobutamine/arbutamine - arrhythmias

Dobutamine and arbutamine produce stimulation of the beta receptors of the heart. The use of these agents has been associated with an increase in heart rate, ventricular ectopy, atrial fibrillation, hypertension, enhanced A-V conduction, and arrhythmias. Therapy with dobutamine or arbutamine should be administered cautiously in patients with cardiac conduction disorders.

References (10)
  1. Bianchi C, Diaz R, Gonzales C, Beregovich J (1975) "Effects of dobutamine on atrioventricular conduction." Am Heart J, 90, p. 474-8
  2. (2002) "Product Information. Dobutrex (dobutamine)." Lilly, Eli and Company
  3. Baudhuin T, Marwick T, Melin J, Wijns W, D'Hondt AM, Detry JM (1993) "Diagnosis of coronary artery disease in elderly patients: safety and efficacy of dobutamine echocardiography." Eur Heart J, 14, p. 799-803
  4. Poldermans D, Fioretti PM, Boersma E, Forster T, Vanurk H, Cornel JH, Arnese M, Roelandt JRTC (1994) "Safety of dobutamine-atropine stress echocardiography in patients with suspected or proven coronary artery disease." Am J Cardiol, 73, p. 456-9
  5. Picano E, Mathias W, Pingitore A, Bigi R, Previtali M (1994) "Safety and tolerability of dobutamine-atropine stress echocardiography: a prospective, multicentre study." Lancet, 344, p. 1190-2
  6. Kinder C, Chamberlain J, Kall J, Kopp D, Johnson M, Costanzo MR, Wilber D (1994) "Prognostic significance of sustained ventricular tachyarrhythmia occurring during dobutamine infusion." J Heart Lung Transplant, 13, p. 1045-50
  7. Cohen A, Chauvel C, Benhalima B, Blanchard B (1995) "Complication of dobutamine stress echocardiography." Lancet, 345, p. 201-2
  8. Tisdale JE, Patel R, Webb CR, Borzak S, Zarowitz BJ (1995) "Electrophysiologic and proarrhythmic effects of intravenous inotropic agents." Prog Cardiovasc Dis, 38, p. 167-80
  9. Previtali M, Lanzarini L, Fetiveau R, Poli A, Diotallevi P (1996) "Dobutamine-induced and spontaneous sustained ventricular tachycardia in recent myocardial infarction." Eur Heart J, 17, p. 803-4
  10. (2001) "Product Information. GenESA (arbutamine)." Gensia Inc

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Dobutrex drug interactions

There are 176 drug interactions with Dobutrex (dobutamine).

Dobutrex disease interactions

There are 5 disease interactions with Dobutrex (dobutamine) which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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