Tapentadol Drug Interactions
Currently displaying a list of 399 drugs known to interact with tapentadol.
- 186 major drug interactions
- 212 moderate drug interactions
- 1 minor drug interaction
Medications known to interact with tapentadol
Note: Showing generic names only.
5
A
- acetylcarbromal
- acrivastine
- albuterol
- aldesleukin
- alfentanil
- allopurinol
- almotriptan
- alprazolam
- amifampridine
- amitriptyline
- amobarbital
- amoxapine
- amphetamine
- apomorphine
- apraclonidine ophthalmic
- arformoterol
- aripiprazole
- asenapine
- atezolizumab
- atomoxetine
- atropine
- avelumab
- azatadine
- azelastine nasal
B
- baclofen
- baricitinib
- belladonna
- benzphetamine
- benztropine
- biperiden
- bitolterol
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- buprenorphine
- bupropion
- buspirone
- butabarbital
- butalbital
- butorphanol
C
- cannabidiol
- cannabis
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- cemiplimab
- cenobamate
- cetirizine
- chlophedianol
- chloral hydrate
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorzoxazone
- citalopram
- clemastine
- clidinium
- clobazam
- clomipramine
- clonazepam
- clonidine
- clopidogrel
- clorazepate
- clozapine
- codeine
- cosibelimab
- cyclizine
- cyclobenzaprine
- cyproheptadine
D
- dantrolene
- daridorexant
- darifenacin
- desipramine
- desmopressin
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- dexfenfluramine
- dexmedetomidine
- dextroamphetamine
- dextromethorphan
- dezocine
- diazepam
- dicyclomine
- diethylpropion
- difelikefalin
- dihydroergotamine
- dimenhydrinate
- diphenhydramine
- dipivefrin ophthalmic
- divalproex sodium
- dobutamine
- dolasetron
- dopamine
- dostarlimab
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- droperidol
- duloxetine
- durvalumab
E
- efavirenz
- eletriptan
- eluxadoline
- entacapone
- ephedrine
- ephedrine nasal
- epinephrine
- epinephrine ophthalmic
- epinephrine topical
- ergotamine
- escitalopram
- esketamine
- eslicarbazepine
- estazolam
- eszopiclone
- ethanol
- ethchlorvynol
- ethosuximide
- ethotoin
- evening primrose
- ezogabine
F
- felbamate
- fenfluramine
- fentanyl
- fesoterodine
- flavoxate
- flibanserin
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- formoterol
- fosphenytoin
- frovatriptan
- furazolidone
G
- gabapentin
- gabapentin enacarbil
- ganaxolone
- gepirone
- ginkgo
- glycopyrrolate
- glycopyrronium topical
- granisetron
H
- halazepam
- haloperidol
- heroin
- hydrocodone
- hydromorphone
- hydroxyamphetamine ophthalmic
- hydroxyzine
- hyoscyamine
I
- ifosfamide
- iloperidone
- imipramine
- indacaterol
- indocyanine green
- iobenguane I 123
- iobenguane I 131
- iohexol
- iomeprol
- iopamidol
- ipilimumab
- isocarboxazid
- isoetharine
- isoproterenol
K
L
- lamotrigine
- lasmiditan
- lemborexant
- levalbuterol
- levetiracetam
- levmetamfetamine nasal
- levocetirizine
- levodopa
- levomethadyl acetate
- levomilnacipran
- levorphanol
- lidocaine
- lindane topical
- linezolid
- lisdexamfetamine
- lithium
- lofexidine
- lorazepam
- lorcaserin
- loxapine
- lumateperone
- lurasidone
M
- ma huang
- maprotiline
- mazindol
- mebrofenin
- meclizine
- melatonin
- mepenzolate
- meperidine
- mephentermine
- mephenytoin
- mephobarbital
- meprobamate
- mesoridazine
- metaproterenol
- metaraminol
- metaxalone
- methadone
- methamphetamine
- methdilazine
- methocarbamol
- methohexital
- methotrimeprazine
- methoxamine
- methscopolamine
- methsuximide
- methylene blue
- metoclopramide
- metrizamide
- metyrosine
- midazolam
- midodrine
- milnacipran
- mirtazapine
- mitotane
- molindone
- morphine
- morphine liposomal
N
- nabilone
- nalbuphine
- naloxone
- naltrexone
- naphazoline nasal
- naphazoline ophthalmic
- naratriptan
- nefazodone
- nivolumab
- norepinephrine
- nortriptyline
O
- olanzapine
- oliceridine
- olodaterol
- olopatadine nasal
- ondansetron
- opicapone
- opium
- orphenadrine
- oxazepam
- oxcarbazepine
- oxybutynin
- oxycodone
- oxymetazoline nasal
- oxymetazoline ophthalmic
- oxymetazoline topical
- oxymorphone
- ozanimod
P
- paliperidone
- palonosetron
- paraldehyde
- paramethadione
- paroxetine
- pegvisomant
- pembrolizumab
- penpulimab
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perphenazine
- phenacemide
- phendimetrazine
- phenelzine
- phenindamine
- phenobarbital
- phensuximide
- phentermine
- phenylephrine
- phenylephrine nasal
- phenylephrine ophthalmic
- phenylephrine topical
- phenylpropanolamine
- phenytoin
- pimozide
- pirbuterol
- polyethylene glycol 3350 with electrolytes
- pramipexole
- prasugrel
- pregabalin
- primidone
- procarbazine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propantheline
- propiomazine
- propofol
- propoxyphene
- propylhexedrine nasal
- protriptyline
- pseudoephedrine
- pyrilamine
Q
R
- racepinephrine
- ramelteon
- rasagiline
- remifentanil
- remimazolam
- retifanlimab
- risperidone
- ritodrine
- rizatriptan
- ropeginterferon alfa-2b
- ropinirole
- rotigotine
- rufinamide
S
- safinamide
- salmeterol
- scopolamine
- secobarbital
- selegiline
- sertraline
- sibutramine
- sodium oxybate
- sodium polystyrene sulfonate
- sofpironium topical
- solifenacin
- solriamfetol
- st. john's wort
- stiripentol
- sufentanil
- sumatriptan
- suvorexant
T
- tasimelteon
- tedizolid
- temazepam
- terbutaline
- tetrabenazine
- tetrahydrozoline nasal
- tetrahydrozoline ophthalmic
- thalidomide
- thiethylperazine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- ticagrelor
- tirzepatide
- tislelizumab
- tizanidine
- tofacitinib
- tolcapone
- tolterodine
- topiramate
- toripalimab
- tramadol
- tranylcypromine
- trazodone
- tremelimumab
- triazolam
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- trospium
- tryptophan
U
V
X
Z
Tapentadol alcohol/food interactions
There is 1 alcohol/food interaction with tapentadol.
Tapentadol disease interactions
There are 14 disease interactions with tapentadol which include:
- impaired GI motility
- infectious diarrhea
- prematurity
- acute alcohol intoxication
- drug dependence
- hypotension
- intracranial pressure
- respiratory depression
- gastrointestinal obstruction
- liver disease
- renal dysfunction
- seizure disorders
- urinary retention
- biliary tract disease
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More about tapentadol
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- Reviews (436)
- Latest FDA alerts (1)
- Side effects
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- During pregnancy
- Drug class: Opioids (narcotic analgesics)
- Breastfeeding
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
