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Drug interactions between grapefruit and simvastatin

Results for the following 2 drugs:
grapefruit
simvastatin

Interactions between your drugs

There were no interactions found in our database between grapefruit and simvastatin - however, this does not necessarily mean no interactions exist. Always consult with your doctor or pharmacist.

grapefruit

A total of 0 drugs are known to interact with grapefruit.

    simvastatin

    A total of 296 drugs are known to interact with simvastatin.

    Drug and food interactions

    Major

    simvastatin food

    Applies to: simvastatin

    Grapefruit juice can significantly increase the blood levels of simvastatin. This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. In some cases, rhabdomyolysis can cause kidney damage and even death. You should avoid the consumption of grapefruit or grapefruit juice during treatment with simvastatin. Let your doctor know immediately if you have unexplained muscle pain, tenderness, or weakness during treatment, especially if these symptoms are accompanied by fever or dark colored urine. You should also seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

    Switch to professional interaction data

    Therapeutic duplication warnings

    No warnings were found for your selected drugs.

    Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

    Drug Interaction Classification

    The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
    Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
    Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
    Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
    Unknown No information available.

    Do not stop taking any medications without consulting your healthcare provider.

    Further information

    Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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