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Omadacycline Dosage

Medically reviewed by Drugs.com. Last updated on May 15, 2019.

Applies to the following strengths: 100 mg; 150 mg

Usual Adult Dose for Pneumonia

Loading Dose: 200 mg via IV infusion (over 60 minutes) on day 1 OR 100 mg via IV infusion (over 30 minutes) twice on day 1

Maintenance Dose:
-IV: 100 mg via IV infusion (over 30 minutes) once a day
-Oral: 300 mg orally once a day

Duration of Therapy: 7 to 14 days

Use: For the treatment of patients with community-acquired bacterial pneumonia due to the following susceptible microorganisms: Streptococcus pneumoniae, Staphylococcus aureus (methicillin-susceptible isolates), Haemophilus influenzae, H parainfluenzae, Klebsiella pneumoniae, Legionella pneumophila, Mycoplasma pneumoniae, Chlamydophila pneumoniae

Usual Adult Dose for Skin and Structure Infection

Loading Dose:
-IV: 200 mg via IV infusion (over 60 minutes) on day 1 OR 100 mg via IV infusion (over 30 minutes) twice on day 1
-Oral: 450 mg orally once a day on day 1 and day 2

Maintenance Dose:
-IV: 100 mg via IV infusion (over 30 minutes) once a day
-Oral: 300 mg orally once a day

Duration of Therapy: 7 to 14 days

Use: For the treatment of patients with acute bacterial skin and skin structure infections due to the following susceptible microorganisms: S aureus (methicillin-susceptible and -resistant isolates), S lugdunensis, S pyogenes, S anginosus group (includes S anginosus, S intermedius, and S constellatus), Enterococcus faecalis, Enterobacter cloacae, K pneumoniae

Renal Dose Adjustments

Mild, moderate, or severe liver dysfunction: No adjustment recommended.

Liver Dose Adjustments

Mild, moderate, or severe liver dysfunction (Child-Pugh A, B, or C): No adjustment recommended.

Precautions

CONTRAINDICATIONS:
Known hypersensitivity to the active component, tetracycline-class antibacterial agents, or any of the ingredients

Safety and efficacy have not been established in patients younger than 18 years; this drug is not recommended for use in patients younger than 8 years.

Consult WARNINGS section for additional precautions.

Dialysis

ESRD receiving hemodialysis: No adjustment recommended.

Other Comments

Administration advice:
IV:
-After reconstitution and dilution, administer via IV infusion (total infusion time: 60 minutes for 200 mg dose or 30 minutes for 100 mg dose); administer through a dedicated line or through a Y-site.
-If the same IV line is used for sequential infusion of several drugs, flush the line before and after infusion of this drug with 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP.
-Do not administer with any solution containing multivalent cations (e.g., calcium, magnesium) through the same IV line; co-infusion with other agents not studied.
Oral:
-Fast for at least 4 hours and then administer with water; after administration, do not consume food or drink (except water) for 2 hours and do not consume dairy products, antacids, or multivitamins for 4 hours.

Storage requirements:
-Lyophilized powder and tablets: Store at 20C to 25C (68F to 77F); excursions permitted to 15C to 30C (59F to 86F); do not freeze.
-Diluted infusion solution: May be used within 12 hours at room temperature (up to 25C [77F]) or within 7 days when refrigerated at 2C to 8C (36F to 46F); do not freeze; allow infusion bag to reach room temperature before use.

Reconstitution/preparation techniques:
-IV: This drug must be reconstituted and then further diluted (within 1 hour); the manufacturer product information should be consulted.

IV compatibility:
-Compatible IV solutions: 0.9% Sodium Chloride Injection, USP; 5% Dextrose Injection, USP
-Compatibility with other drugs and infusion solutions not established.

General:
-To reduce the development of drug-resistant organisms and maintain effective therapy, this drug should be used only to treat or prevent infections proven or strongly suspected to be caused by susceptible bacteria.
-Culture and susceptibility information should be considered when selecting/modifying antibacterial therapy or, if no data are available, local epidemiology and susceptibility patterns may be considered when selecting empiric therapy.

Patient advice:
-Avoid missing doses and complete the entire course of therapy.
-Notify healthcare provider immediately if you become pregnant during therapy.
-Contact physician as soon as possible if watery or bloody stools (with or without stomach cramps and fever) develop.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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