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Isoptin SR Dosage

Medically reviewed by Last updated on Mar 1, 2022.

Generic name: verapamil hydrochloride
Dosage form: tablets

Essential Hypertension

The dose of ISOPTIN SR should be individualized by titration and the drug should be administered with food. Initiate therapy with 180 mg of sustained-release verapamil HCI, ISOPTIN SR, given in the morning. Lower, initial doses of 120 mg a day may be warranted in patients who may have an increased response to verapamil (e.g., the elderly or small people etc.). Upward titration should be based on therapeutic efficacy and safety evaluated weekly and approximately 24 hours after the previous dose. The antihypertensive effects of ISOPTIN SR are evident within the first week of therapy.

If adequate response is not obtained with 180 mg of ISOPTIN SR, the dose may be titrated upward in the following manner:

a) 240 mg each morning,

b) 180 mg each morning plus 180 mg each evening, or 240 mg each morning plus 120 mg each evening

c) 240 mg every twelve hours.

When switching from immediate release ISOPTIN to ISOPTIN SR, the total daily dose in milligrams may remain the same.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.