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Generic name: delavirdine [ de-la-VIR-deen ]
Brand name: Rescriptor
Drug class: NNRTIs

What is delavirdine?

Delavirdine is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body.

Delavirdine is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Delavirdine is not a cure for HIV or AIDS.

Delavirdine may also be used for purposes not listed in this medication guide.


Delavirdine must be given in combination with other antiviral medications and it should not be used alone.

Some medicines can cause unwanted or dangerous effects when used with delavirdine. Tell your doctor about all your current medicines and any you start or stop using.

Before taking this medicine

You should not use delavirdine if you are allergic to it.

Some medicines can interact with delavirdine and should not be used at the same time. Your doctor may need to change your treatment plan if you use any of the following drugs:

Using any of these medicines while you are taking delavirdine can cause serious medical problems or death.

To make sure delavirdine is safe for you, tell your doctor if you have:

  • liver or kidney disease;

  • high cholesterol or triglycerides;

  • low stomach acid production; or

  • if you have ever taken any HIV medication that was not effective in treating your condition.

It is not known whether delavirdine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.

Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

Related/similar drugs

Biktarvy, Genvoya, Stribild, Triumeq, Truvada, ritonavir, Complera

How should I take delavirdine?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Delavirdine must be given in combination with other antiviral medications and it should not be used alone.

You may take delavirdine with or without food. If you have a condition of low stomach acid, your doctor may recommend taking delavirdine with an acidic beverage such as orange or cranberry juice.

The 100-milligram delavirdine tablets may be dissolved in water to make swallowing easier. Place 4 tablets into at least 3 ounces (just under 1/3 cup) of water. Let the liquid stand for a few minutes, then stir to allow the tablets to disperse evenly in the liquid. Drink this mixture right away. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away.

The 200-milligram delavirdine tablets must be swallowed whole. Do not crush, chew, or disperse the tablets in water.

While using delavirdine, you may need frequent blood tests.

Use delavirdine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking delavirdine?

Avoid taking an herbal supplement containing St. John's wort at the same time you are taking delavirdine.

Avoid taking an antacid within 1 hour before or after you take delavirdine. Some antacids can make it harder for your body to absorb delavirdine.

Taking delavirdine will not prevent you from passing HIV to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Delavirdine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using delavirdine and call your doctor at once if you have a severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Delavirdine may increase your risk of certain infections or autoimmune disorders by changing the way your immune system works. Symptoms may occur weeks or months after you start treatment with delavirdine. Tell your doctor if you have:

  • signs of a new infection--fever, night sweats, swollen glands, mouth sores, diarrhea, stomach pain, weight loss;

  • chest pain (especially when you breathe), dry cough, wheezing, feeling short of breath;

  • cold sores, sores on your genital or anal area;

  • rapid heart rate, feeling anxious or irritable, weakness or prickly feeling, problems with balance or eye movement;

  • trouble speaking or swallowing, severe lower back pain, loss of bladder or bowel control; or

  • swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence, loss of interest in sex.

Common side effects may include:

  • mild skin rash;

  • nausea, diarrhea;

  • feeling tired;

  • headache; or

  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Delavirdine dosing information

Usual Adult Dose for HIV Infection:

400 mg orally 3 times a day

Use: In combination with at least 2 other active antiretroviral agents, for the treatment of HIV-1 infection

Usual Pediatric Dose for HIV Infection:

16 years or older: 400 mg orally 3 times a day

Use: In combination with at least 2 other active antiretroviral agents, for the treatment of HIV-1 infection

What other drugs will affect delavirdine?

Delavirdine can raise blood levels of certain other drugs you may be using, which could increase side effects. Your doctor may need to adjust your doses if you use any of the following drugs:

Many other drugs can interact with delavirdine. Tell your doctor about all your current medicines and any you start or stop using, especially:

  • ADHD medication such as Adderall;

  • cholesterol-lowering medication;

  • an antibiotic or antifungal medicine;

  • heart or blood pressure medicine;

  • medicine to prevent organ transplant rejection; or

  • medicine to reduce stomach acid.

This list is not complete and many other drugs can interact with delavirdine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with delavirdine. Give a list of all your medicines to any healthcare provider who treats you.

More about delavirdine

Patient resources

Other brands


Related treatment guides

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.