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Rescriptor (Oral)

Generic Name: delavirdine (Oral route)

del-a-VIR-deen

Commonly used brand name(s)

In the U.S.

  • Rescriptor

Available Dosage Forms:

  • Tablet

Therapeutic Class: Antiretroviral Agent

Pharmacologic Class: Non-Nucleoside Reverse Transcriptase Inhibitor

Uses For Rescriptor

Delavirdine is used, in combination with other medicines, in the treatment of the infection caused by the human immunodeficiency virus (HIV). HIV is the virus that causes acquired immune deficiency syndrome (AIDS).

Delavirdine will not cure or prevent HIV infection or AIDS; however, it helps keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay the development of problems usually related to AIDS or HIV disease. Delavirdine will not keep you from spreading HIV to other people. People who receive this medicine may continue to have other problems usually related to AIDS or HIV disease.

This medicine is available only with your doctor's prescription.

Before Using Rescriptor

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Geriatric

Delavirdine has not been studied specifically in older people. Therefore, it is not known whether it causes different side effects or problems in the elderly than it does in younger adults.

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Alprazolam
  • Astemizole
  • Carbamazepine
  • Cisapride
  • Conivaptan
  • Dihydroergotamine
  • Eliglustat
  • Ergonovine
  • Ergotamine
  • Fosamprenavir
  • Fosphenytoin
  • Isavuconazonium Sulfate
  • Methylergonovine
  • Midazolam
  • Naloxegol
  • Nimodipine
  • Phenytoin
  • Pimozide
  • Primidone
  • Terfenadine
  • Tolvaptan
  • Triazolam

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amiodarone
  • Artemether
  • Bedaquiline
  • Bepridil
  • Bosutinib
  • Brentuximab Vedotin
  • Bupropion
  • Cabazitaxel
  • Ceritinib
  • Cilostazol
  • Cimetidine
  • Cobicistat
  • Crizotinib
  • Darunavir
  • Delamanid
  • Domperidone
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Etravirine
  • Famotidine
  • Fentanyl
  • Flecainide
  • Idelalisib
  • Ifosfamide
  • Ixabepilone
  • Ketoconazole
  • Lansoprazole
  • Lidocaine
  • Lovastatin
  • Lumefantrine
  • Lurasidone
  • Methadone
  • Nevirapine
  • Nizatidine
  • Olaparib
  • Omeprazole
  • Panobinostat
  • Paroxetine
  • Phenobarbital
  • Piperaquine
  • Propafenone
  • Quinidine
  • Ranitidine
  • Rifabutin
  • Rifampin
  • Rilpivirine
  • Ruxolitinib
  • Saquinavir
  • Simeprevir
  • Simvastatin
  • St John's Wort
  • Tacrolimus
  • Vilazodone
  • Voriconazole

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aluminum Carbonate, Basic
  • Aluminum Hydroxide
  • Aluminum Phosphate
  • Amprenavir
  • Cerivastatin
  • Clarithromycin
  • Dalfopristin
  • Desogestrel
  • Didanosine
  • Dienogest
  • Dihydroxyaluminum Aminoacetate
  • Dihydroxyaluminum Sodium Carbonate
  • Drospirenone
  • Ergoloid Mesylates
  • Estradiol Cypionate
  • Estradiol Valerate
  • Ethinyl Estradiol
  • Ethynodiol Diacetate
  • Etonogestrel
  • Fluoxetine
  • Indinavir
  • Lacidipine
  • Lercanidipine
  • Levonorgestrel
  • Magaldrate
  • Magnesium Carbonate
  • Magnesium Hydroxide
  • Magnesium Oxide
  • Magnesium Trisilicate
  • Manidipine
  • Medroxyprogesterone Acetate
  • Mestranol
  • Nelfinavir
  • Nilvadipine
  • Norelgestromin
  • Norethindrone
  • Norgestimate
  • Norgestrel
  • Quinupristin
  • Rifapentine
  • Ritonavir
  • Sildenafil

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Achlorhydria (absence of stomach acid)—Delavirdine should be taken with an acidic beverage such as orange or cranberry juice
  • Liver disease—Effects of delavirdine may be increased because of slower removal from the body

Proper Use of Rescriptor

This medicine can be taken with our without food.

It is very important that you find out about medicines that can not be taken with delavirdine.

It is best to swallow both the 100 milligram (mg) and 200 milligram (mg) tablets whole. However, if swallowing is difficult, the 100 milligram (mg) tablet can be put in a glass of water (at least 3 ounces), allowed to sit for a few minutes, and then stirred to mix. Drink the mixture right away. Then rinse the glass with water and drink that rinse to make sure the full dose is taken.

Note: Only the 100 milligram (mg) tablets can be put into a glass of water to dissolve. The 200 milligram (mg) tablets must be swallowed whole.

Do not take any antacid medications within 1 hour of the time you take delavirdine. They may prevent delavirdine from being absorbed into the body.

For patients with achlorhydria (absence of stomach acid) they should take delavirdine with a glass of orange juice or cranberry juice.

Take this medicine exactly as directed by your doctor. Do not take it more often, and do not take it for a longer time than your doctor ordered. Also, do not stop taking this medicine without checking with your doctor first.

Keep taking delavirdine for the full time of treatment, even if you begin to feel better.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For treatment of HIV infection:
      • Adults—400 mg three times a day in combination with other antiretroviral medicines. Your healthcare professional will decide on the other medicines needed and how much you will use.
      • Children younger than 16 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Rescriptor

It is very important that your doctor check your progress at regular visits.

Rescriptor Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common
  • Skin rash (severe) with itching
Less common
  • Skin rash with symptoms such as fever, blistering, oral lesions, conjunctivitis, swelling, muscle aches, or joint aches
Rare
  • Difficulty in breathing
Incidence unknown
  • Agitation
  • back, leg, or stomach pains
  • bleeding gums
  • chills
  • coma
  • confusion
  • dark urine
  • decreased urine output
  • depression
  • difficulty breathing
  • dizziness
  • fatigue
  • fever
  • general body swelling
  • headache
  • hostility
  • irritability
  • lethargy
  • loss of appetite
  • muscle twitching
  • nausea
  • nosebleeds
  • pale skin
  • rapid weight gain
  • seizures (convulsions)
  • sore throat
  • stupor
  • swelling of face, ankles, or hands
  • unusual tiredness or weakness
  • vomiting
  • yellowing of the eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Body aches or pain
  • cough
  • diarrhea
  • discouragement
  • ear congestion
  • fear
  • feeling sad or empty
  • general feeling of discomfort or illness
  • joint pain
  • lack or loss of strength
  • loss of interest or pleasure
  • loss of voice
  • muscle aches and pains
  • nasal congestion
  • nervousness
  • pain, localized
  • pain or tenderness around eyes and cheekbones
  • runny nose
  • shivering
  • shortness of breath
  • sneezing
  • sweating
  • tightness in chest
  • tiredness
  • trouble concentrating
  • trouble sleeping
  • wheezing
Less common
  • Abdominal pain, generalized
  • dryness or soreness of throat
  • hoarseness
  • sleeplessness
  • tender, swollen glands in neck
  • trouble in swallowing
  • unable to sleep
  • voice changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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