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Homatropine / Hydrocodone Dosage

Medically reviewed on August 25, 2017.

Applies to the following strengths: 1.5 mg-5 mg; 1.5 mg-5 mg/5 mL

Usual Adult Dose for Cough

One tablet OR 5 mL orally every 4 to 6 hours as needed
Maximum dose: 6 tablets OR 30 mL in 24 hours

Comments:
-Each tablet contains hydrocodone 5 mg-homatropine 1.5 mg
-Each 5 mL contains hydrocodone 5 mg-homatropine 1.5 mg

Use: Symptomatic relief of cough.

Renal Dose Adjustments

Use with caution

Liver Dose Adjustments

Use with caution

Dose Adjustments

Elderly: Use with caution

Precautions

US BOXED WARNING: RISKS FROM CONCOMITANT USE WITH BENZODIAZEPINES OR OTHER CNS DEPRESSANTS:
-Concomitant use of opioids with benzodiazepines or other CNS depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. Avoid use of opioid cough medications in patients taking benzodiazepines, other CNS depressants, or alcohol.

The US FDA recommends against use of hydrocodone-containing cough and cold medications in patients less than 18 years because it has been determined that the risks outweigh benefits.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule II

Dialysis

Data not available

Other Comments

Administration advice:
-Take orally as needed for cough
-Measure oral syrup with an accurate measuring device; a household teaspoon should not be considered an accurate measuring device

Storage requirements:
-Protect from light

General:
-The US FDA recommends against use of hydrocodone-containing cough and cold medications in patients less than 18 years because it has been determined that the risks outweigh benefits.
-Hydrocodone is the active component of this combination product; homatropine is included in a subtherapeutic amount to discourage deliberate overdose.

Monitoring:
-Monitor for respiratory difficulties
-Monitor for the development of addiction, abuse, or misuse

Patient advice:
-Advise patients to store this drug safely out of the sight and reach of children; accidental use by a child should be considered a medical emergency as it can result in death.
-Patients should understand the risks of life-threatening respiratory depression, and should be informed as to when this risk is greatest.
-Women of child bearing potential should understand that prolonged opioid use during pregnancy can result in neonatal opioid withdrawal syndrome and that prompt recognition and treatment will be necessary; breastfeeding women should speak to their health care provider prior to using this drug.
-Patients should be instructed in proper disposal.
-Patients should not consume alcoholic beverages or take this drug with benzodiazepines or other CNS depressants; patients should avoid driving or operating machinery while taking this drug.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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