Cipro Tablets Dosage
Generic name: CIPROFLOXACIN HYDROCHLORIDE 250mg
Dosage form: tablet, film coated
Drug class: Quinolones and fluoroquinolones
Medically reviewed by Drugs.com. Last updated on Sep 5, 2024.
CIPRO Tablets and Oral Suspension should be administered orally as described in the appropriate Dosage Guidelines tables.
Dosage in Adults
The determination of dosage and duration for any particular patient must take into consideration the severity and nature of the infection, the susceptibility of the causative microorganism, the integrity of the patient’s host-defense mechanisms, and the status of renal and hepatic function.
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4 to 8 weeks |
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Conversion of IV to Oral Dosing in Adults
Patients whose therapy is started with CIPRO IV may be switched to CIPRO Tablets or Oral Suspension when clinically indicated at the discretion of the physician (Table 2).
CIPRO Oral Dosage |
Equivalent CIPRO IV Dosage |
250 mg Tablet every 12 hours |
200 mg intravenous every 12 hours |
500 mg Tablet every 12 hours |
400 mg intravenous every 12 hours |
750 mg Tablet every 12 hours |
400 mg intravenous every 8 hours |
Dosage in Pediatric Patients
Dosing and initial route of therapy (that is, IV or oral) for cUTI or pyelonephritis should be determined by the severity of the infection. CIPRO should be administered as described in Table 3.
Infection | Dose | Frequency | Total Duration |
---|---|---|---|
Complicated Urinary Tract or Pyelonephritis (patients from 1 to 17 years of age) |
10 mg/kg to 20 mg/kg (maximum 750 mg per dose; not to be exceeded even in patients weighing more than 51 kg) |
Every 12 hours |
10–21 days |
Inhalational Anthrax (Post-Exposure)2 |
15 mg/kg (maximum 500 mg per dose) |
Every 12 hours |
60 days |
Plague2,3 |
15 mg/kg (maximum 500 mg per dose) |
Every 8 to 12 hours |
10–21 days |
Dosage Modifications in Patients with Renal Impairment
Ciprofloxacin is eliminated primarily by renal excretion; however, the drug is also metabolized and partially cleared through the biliary system of the liver and through the intestine. These alternative pathways of drug elimination appear to compensate for the reduced renal excretion in patients with renal impairment. Nonetheless, some modification of dosage is recommended, particularly for patients with severe renal dysfunction. Dosage guidelines for use in patients with renal impairment are shown in Table 4.
Creatinine Clearance (mL/min) |
Dose |
> 50 |
See Usual Dosage. |
30–50 |
250–500 mg every12 hours |
5–29 |
250–500 mg every 18 hours |
Patients on hemodialysis or Peritoneal dialysis |
250–500 mg every 24 hours (after dialysis) |
When only the serum creatinine concentration is known, the following formulas may be used to estimate creatinine clearance:
Men - Creatinine clearance (mL/min) = Weight (kg) x (140–age) |
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72 x serum creatinine (mg/dL) |
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Women - 0.85 x the value calculated for men. |
The serum creatinine should represent a steady state of renal function.
In patients with severe infections and severe renal impairment, a unit dose of 750 mg may be administered at the intervals noted above. Patients should be carefully monitored.
Pediatric patients with moderate to severe renal insufficiency were excluded from the clinical trial of cUTI and pyelonephritis. No information is available on dosing adjustments necessary for pediatric patients with moderate to severe renal insufficiency (that is, creatinine clearance of < 50 mL/min/1.73m2).
Important Administration Instructions
With Multivalent Cations
Administer CIPRO at least 2 hours before or 6 hours after magnesium/aluminum antacids; polymeric phosphate binders (for example, sevelamer, lanthanum carbonate) or sucralfate; Videx® (didanosine) chewable/buffered tablets or pediatric powder for oral solution; other highly buffered drugs; or other products containing calcium, iron or zinc.
Directions for Reconstitution of the CIPRO Microcapsules for Oral Suspension
CIPRO Oral Suspension is supplied in 5% (5 g ciprofloxacin in 100 mL) and 10% (10 g ciprofloxacin in 100 mL) strengths. CIPRO oral suspension is composed of two components (microcapsules and diluent) that must be combined prior to dispensing.
Dose |
5% |
10% |
250 mg |
5 mL |
2.5 mL |
500 mg |
10 mL |
5 mL |
750 mg |
15 mL |
7.5 mL |
Preparation of the suspension:
Step 5: Write the expiration date of the re-constituted oral suspension on the bottle label.
Reconstituted product may be stored below 30°C (86°F) for 14 days. Protect from freezing.
No additions should be made to the mixed final ciprofloxacin suspension. CIPRO Oral Suspension should not be administered through feeding or NG (nasogastric) tubes due to its physical characteristics.
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