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Brivaracetam Dosage

Applies to the following strength(s): 10 mg ; 25 mg ; 50 mg ; 75 mg ; 100 mg ; 10 mg/mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Epilepsy

Initial dose: 50 mg orally or IV 2 times a day, once in the morning and once in the evening (100 mg/day)
Maintenance dose: The dosage may be adjusted down to 25 mg orally or IV 2 times a day (50 mg per day) or up to 100 mg orally or IV 2 times a day (200 mg per day) once in the morning and once in the evening (based on patient response and tolerability)

Comments:
-Gradual dose escalation is not required.
-The IV formulation may be used when oral administration is temporarily not feasible; the IV formulation should be administered at the same dosage and same frequency as tablets and oral solution.
-The IV formulation should be administered over 2 to 15 minutes.
-The clinical study experience with the IV injection is limited to 4 consecutive days of treatment.
-The oral formulation may be taken with or without food.
-The tablets should be swallowed whole with liquid and should not be chewed or crushed.
-If patients missed one dose or more, it is recommended that they take a single dose as soon as they remember and take the following dose at the usual morning or evening time. This may avoid the plasma concentration falling below the efficacy level and prevent breakthrough seizures from occurring.

Use: As adjunctive therapy in the treatment of partial-onset seizures

Usual Pediatric Dose for Epilepsy

16 years of age and older:
Initial dose: 50 mg orally or IV 2 times a day, once in the morning and once in the evening (100 mg/day)
Maintenance dose: The dosage may be adjusted down to 25 mg orally or IV 2 times a day (50 mg per day) or up to 100 mg orally or IV 2 times a day (200 mg per day) once in the morning and once in the evening (based on patient response and tolerability)

Comments:
-Gradual dose escalation is not required.
-The IV formulation may be used when oral administration is temporarily not feasible; the IV formulation should be administered at the same dosage and same frequency as tablets and oral solution.
-The IV formulation should be administered over 2 to 15 minutes.
-The clinical study experience with the IV injection is limited to 4 consecutive days of treatment.
-The oral formulation may be taken with or without food.
-The tablets should be swallowed whole with liquid and should not be chewed or crushed.
-If patients missed one dose or more, it is recommended that they take a single dose as soon as they remember and take the following dose at the usual morning or evening time. This may avoid the plasma concentration falling below the efficacy level and prevent breakthrough seizures from occurring.

Use: As adjunctive therapy in the treatment of partial-onset seizures in patients 16 years of age and older with epilepsy

Renal Dose Adjustments

Mild, moderate, or severe renal dysfunction: No adjustment recommended.
End state renal dysfunction (CrCl less than 15 mL/min): Not recommended.

Liver Dose Adjustments

For all stages of hepatic impairment, the recommended starting dose is 25 mg 2 times a day (50 mg per day) and the recommended maximum dosage is 75 mg 2 times a day (150 mg per day)

Dose Adjustments

-Tablets, oral solution, and injection can be used interchangeably.
-Avoid abrupt withdrawal of therapy in order to minimize the risk of increased seizure frequency and status epilepticus.
-When this drug is coadministered with rifampin, increase the dose of this drug by up to 100% (i.e., double the dosage).

Precautions

Safety and efficacy have not been established in patients younger than 16 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule V

Dialysis

Not recommended

Other Comments

Administration advice:
-The oral formulation may be taken with or without food.
-The tablets should be swallowed whole with liquid and should not be chewed or crushed.
-A calibrated measuring device is recommended to accurately measure and deliver the prescribed dose of the liquid formulation. A household teaspoon or tablespoon is not an adequate measuring device.
-The oral solution should be discarded after 5 months of first opening the bottle.
-When using the oral solution, no dilution is necessary.
-The oral solution may be administered using a nasogastric tube or gastrostomy tube.
-The IV formulation should be administered over 2 to 15 minutes.

Reconstitution/preparation techniques:
Refer to the manufacturer product information.

IV compatibility:
Refer to the manufacturer product information.

Patient advice:
-Take this drug exactly as your healthcare provider tells you.
-Take this drug with or without food.
-Swallow the tablets whole with liquid. Do not chew or crush tablets before swallowing.
-If your healthcare provider has prescribed the oral solution, be sure to ask your pharmacist for a medicine dropper or medicine cup to help you measure the correct amount of solution. Do not use a household teaspoon. Ask your pharmacist for instructions on how to use the measuring device the right way.
-Do not drive or operate machinery until you know how this drug affects you. This drug may cause drowsiness, tiredness, dizziness, and problems with your balance and coordination.

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