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Brivaracetam Pregnancy and Breastfeeding Warnings

Brivaracetam is also known as: Briviact

Brivaracetam Pregnancy Warnings

This drug should be used during pregnancy only if the benefit outweighs the risk. US FDA pregnancy category: C

-In animal studies, this drug produced evidence of developmental toxicity at plasma exposures greater than clinical exposures. There are no controlled data in human pregnancy. -For all antiepileptic drugs, it has been shown that in the offspring of treated women with epilepsy, the prevalence of malformations is 2 to 3 times greater than the rate of approximately 3% in the general population. In the treated population, an increase in malformations has been noted with polytherapy; however, the extent to which the treatment and/or the underlying condition is responsible has not been elucidated. -Discontinuation of antiepileptic treatments may result in exacerbation of the disease which could be harmful to the mother and the fetus.

See references

Brivaracetam Breastfeeding Warnings

A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother. Excreted into human milk: Unknown Excreted into animal milk: Yes Comments: -The effects in the nursing infant are unknown. -When this drug is coadministered with carbamazepine, the amount of carbamazepine-epoxide excreted in breast milk could increase. There is insufficient data to determine the clinical significance.

See references

References for pregnancy information

  1. "Product Information. Briviact (brivaracetam)." UCB Pharma Inc, Smyrna, GA.
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

References for breastfeeding information

  1. "Product Information. Briviact (brivaracetam)." UCB Pharma Inc, Smyrna, GA.
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

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