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Trospium Disease Interactions

There are 7 disease interactions with trospium.

Major

Trospium (applies to trospium) gastric retention

Major Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Obstruction

Trospium, similarly to other anticholinergic drugs, may decrease gastrointestinal motility and therefore its use is contraindicated in patients with gastric retention.

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Major

Trospium (applies to trospium) narrow angle glaucoma

Major Potential Hazard, Moderate plausibility. Applicable conditions: Glaucoma (Narrow Angle)

The use of trospium is contraindicated in patients with uncontrolled narrow-angle glaucoma. In those patients being treated for narrow-angle glaucoma, trospium should only be used if the potential benefits outweigh the risks and in that circumstance only with careful monitoring.

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Major

Trospium (applies to trospium) urinary retention

Major Potential Hazard, Moderate plausibility.

Trospium antagonizes the effect of acetylcholine on muscarinic receptors in cholinergically innervated organs including the bladder. Its parasympatholytic action reduces the tonus of smooth muscle in the bladder, and therefore its use is contraindicated in patients with urinary retention.

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Moderate

Trospium (applies to trospium) alcoholism

Moderate Potential Hazard, Moderate plausibility.

The use of alcohol may enhance the drowsiness caused by anticholinergic agents. It is recommended that alcohol should not be consumed within 2 hours of trospium administration. Caution should be exercised when using this agent in alcoholic patients.

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Moderate

Trospium (applies to trospium) gastrointestinal obstruction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Ulcerative Colitis, Myasthenia Gravis

Trospium antagonizes the effect of acetylcholine on muscarinic receptors. Its parasympatholytic action reduces the tonus of smooth muscle. Trospium, like other antimuscarinic agents, may decrease gastrointestinal motility and should be used with caution in patients with conditions such as ulcerative colitis, intestinal atony and myasthenia gravis. Caution should be exercised when using trospium in patients with gastrointestinal obstructive disorders because of the risk of gastric retention.

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Moderate

Trospium (applies to trospium) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Caution is advised when administering trospium to patients with moderate to severe hepatic impairment.

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Moderate

Trospium (applies to trospium) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Trospium is known to be substantially excreted by the kidney, and the risk of adverse reactions may be greater in patients with impaired renal function. The use of trospium is not recommended in patients with severe renal impairment (creatinine clearance less than 30 mL/minute). Caution is recommended when using this agent in patients with creatinine clearance ranging from 30 to 80 mL/min as the pharmacokinetics of trospium have not been studied in patients.

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Trospium drug interactions

There are 215 drug interactions with trospium.

Trospium alcohol/food interactions

There are 2 alcohol/food interactions with trospium.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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