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Ranitidine Disease Interactions

There are 6 disease interactions with ranitidine.


H2 antagonists (applies to ranitidine) GI bleeding

Major Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Hemorrhage

Histamine H2 receptor antagonists should not be used in the presence of vomit with blood, or bloody or black stools. These might be serious conditions and the diagnosis needs to be ruled out.


  1. (2002) "Product Information. Pepcid (famotidine)." Merck & Co., Inc
  2. (2002) "Product Information. Axid (nizatidine)." Lilly, Eli and Company
  3. (2001) "Product Information. Tagamet (cimetidine)." SmithKline Beecham
  4. (2001) "Product Information. Tritec (ranitidine bismuth citrate)." Glaxo Wellcome
  5. (2002) "Product Information. Zantac 75 (ranitidine)." Pfizer U.S. Pharmaceuticals
View all 5 references

Ranitidine (applies to ranitidine) porphyria

Major Potential Hazard, Moderate plausibility.

Ranitidine may rarely precipitate acute porphyria attacks and should be avoided in patients with a history of acute porphyria.


  1. (2001) "Product Information. Zantac (ranitidine)." Glaxo Wellcome

Ranitidine (applies to ranitidine) hemodialysis

Moderate Potential Hazard, High plausibility.

Ranitidine is partially removed by hemodialysis and should be administered after dialysis.


  1. Garg DC, Baltodano N, Perez GO, et al. (1985) "Pharmacokinetics of ranitidine after intravenous administration in hemodialysis patients." Pharmacology, 31, p. 189-93
  2. Comstock TJ, Sica DA, Harford A, Eshelman F (1989) "Ranitidine bioavailability and disposition kinetics in patients undergoing chronic hemodialysis." Nephron, 52, p. 15-9
  3. (2001) "Product Information. Zantac (ranitidine)." Glaxo Wellcome

Ranitidine (applies to ranitidine) liver disease

Moderate Potential Hazard, Low plausibility.

Ranitidine is partially metabolized by the liver. Although dosage reductions are generally not necessary, therapy with ranitidine should be administered cautiously in patients with liver disease. Elevated ALT (SGPT) has been observed in patients receiving ranitidine intravenously at dosages greater than those normally recommended for 5 days or more.


  1. Morichau-Beauchant M, Houin G, Mavier P, et al. (1986) "Pharmacokinetics and bioavailability of ranitidine in normal subjects and cirrhotic patients." Dig Dis Sci, 31, p. 113-8
  2. Young CJ, Daneshmend TK, Roberts CJC (1982) "Effects of cirrhosis and ageing on the elimination and bioavailability of ranitidine." Gut, 23, p. 819-23
  3. Gonzalez-Martin G, Paulos C, Veluso B, et al. (1987) "Ranitidine disposition in severe hepatic cirrhosis." Int J Clin Pharmacol Ther Toxicol, 25, p. 139-42
  4. Smith IL, Ziemniak JA, Bernhard H, et al. (1984) "Ranitidine disposition and systemic availability in hepatic cirrhosis." Clin Pharmacol Ther, 35, p. 487-94
  5. Okolicsanyi L, Venuti M, Strazzabosco M, et al. (1984) "Oral and intravenous pharmacokinetics of ranitidine in patients with liver cirrhosis." Int J Clin Pharmacol Ther Toxicol, 22, p. 329-32
  6. (2001) "Product Information. Zantac (ranitidine)." Glaxo Wellcome
View all 6 references

Ranitidine (applies to ranitidine) PKU

Moderate Potential Hazard, High plausibility. Applicable conditions: Phenylketonuria

Zantac (brand of ranitidine) 150 EFFERdose tablets and granules both contain 16.84 mg of phenylalanine per each 150 mg of ranitidine. The phenylalanine content should be considered when these products are used in patients who must restrict their intake of phenylalanine (i.e. phenylketonurics).


  1. (2001) "Product Information. Zantac (ranitidine)." Glaxo Wellcome

Ranitidine (applies to ranitidine) renal dysfunction

Moderate Potential Hazard, High plausibility.

Ranitidine is primarily eliminated by the kidney. Although the drug is generally well-tolerated, the daily dosage should initially be reduced in patients with moderate to severe renal impairment (CrCl < 50 mL/min). If necessary, the daily dosage may be increased with caution.


  1. McGonigle RJ, Williams LC, Amphlett GE, et al. (1982) "The pharmacokinetics of ranitidine in renal disease." Pharmacokinet Pharmacodynam, p. 41-7
  2. Meffin PJ, Grgurinovich N, Brooks PM, et al. (1983) "Ranitidine disposition in patients with renal impairment." Br J Clin Pharmacol, 16, p. 731-4
  3. Zech PY, Chau NP, Pozet N, et al. (1983) "Ranitidine kinetics in chronic renal impairment." Clin Pharmacol Ther, 34, p. 667-72
  4. McFayden ML, Folb PI, Miller R, et al. (1983) "Pharmacokinetics of ranitidine in patients with chronic renal failure." Eur J Clin Pharmacol, 25, p. 347-51
  5. Garg DC, Baltodano N, Jallad NS, et al. (1986) "Pharmacokinetics of ranitidine in patients with renal failure." J Clin Pharmacol, 26, p. 286-91
  6. Kopitar Z, Cvelbar P, Zorz M, et al. (1987) "Pharmacokinetics of ranitidine in adult patients with end stage renal disease after single and multiple dosing." Acta Pharm Juglosl, 37, p. 371-9
  7. (2001) "Product Information. Zantac (ranitidine)." Glaxo Wellcome
  8. Dixon JS, Borgcostanzi JM, Langley SJ, Lacey LF, Toon S (1994) "The effect of renal function on the pharmacokinetics of ranitidine." Eur J Clin Pharmacol, 46, p. 167-71
  9. Gladziwa U, Klotz U (1994) "Pharmacokinetic optimisation of the treatment of peptic ulcer in patients with renal failure." Clin Pharmacokinet, 27, p. 393-408
View all 9 references

Ranitidine drug interactions

There are 141 drug interactions with ranitidine.

Ranitidine alcohol/food interactions

There is 1 alcohol/food interaction with ranitidine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.