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Ranitidine Disease Interactions

There are 6 disease interactions with ranitidine:

Major

H2 Antagonists (Includes Ranitidine) ↔ Gi Bleeding

Severe Potential Hazard, Moderate plausibility

Applies to: Gastrointestinal Hemorrhage

Histamine H2 receptor antagonists should not be used in the presence of vomit with blood, or bloody or black stools. These might be serious conditions and the diagnosis needs to be ruled out.

Major

Ranitidine (Includes Ranitidine) ↔ Porphyria

Severe Potential Hazard, Moderate plausibility

Applies to: Porphyria

Ranitidine may rarely precipitate acute porphyria attacks and should be avoided in patients with a history of acute porphyria.

References

  1. "Product Information. Zantac (ranitidine)." Glaxo Wellcome, Research Triangle Park, NC.
Moderate

Ranitidine (Includes Ranitidine) ↔ Hemodialysis

Moderate Potential Hazard, High plausibility

Applies to: hemodialysis

Ranitidine is partially removed by hemodialysis and should be administered after dialysis.

References

  1. "Product Information. Zantac (ranitidine)." Glaxo Wellcome, Research Triangle Park, NC.
  2. Comstock TJ, Sica DA, Harford A, Eshelman F "Ranitidine bioavailability and disposition kinetics in patients undergoing chronic hemodialysis." Nephron 52 (1989): 15-9
  3. Garg DC, Baltodano N, Perez GO, et al "Pharmacokinetics of ranitidine after intravenous administration in hemodialysis patients." Pharmacology 31 (1985): 189-93
Moderate

Ranitidine (Includes Ranitidine) ↔ Liver Disease

Moderate Potential Hazard, Low plausibility

Applies to: Liver Disease

Ranitidine is partially metabolized by the liver. Although dosage reductions are generally not necessary, therapy with ranitidine should be administered cautiously in patients with liver disease. Elevated ALT (SGPT) has been observed in patients receiving ranitidine intravenously at dosages greater than those normally recommended for 5 days or more.

References

  1. Morichau-Beauchant M, Houin G, Mavier P, et al "Pharmacokinetics and bioavailability of ranitidine in normal subjects and cirrhotic patients." Dig Dis Sci 31 (1986): 113-8
  2. "Product Information. Zantac (ranitidine)." Glaxo Wellcome, Research Triangle Park, NC.
  3. Smith IL, Ziemniak JA, Bernhard H, et al "Ranitidine disposition and systemic availability in hepatic cirrhosis." Clin Pharmacol Ther 35 (1984): 487-94
View all 6 references
Moderate

Ranitidine (Includes Ranitidine) ↔ Pku

Moderate Potential Hazard, High plausibility

Applies to: Phenylketonuria

Zantac (brand of ranitidine) 150 EFFERdose tablets and granules both contain 16.84 mg of phenylalanine per each 150 mg of ranitidine. The phenylalanine content should be considered when these products are used in patients who must restrict their intake of phenylalanine (i.e. phenylketonurics).

References

  1. "Product Information. Zantac (ranitidine)." Glaxo Wellcome, Research Triangle Park, NC.
Moderate

Ranitidine (Includes Ranitidine) ↔ Renal Dysfunction

Moderate Potential Hazard, High plausibility

Applies to: Renal Dysfunction

Ranitidine is primarily eliminated by the kidney. Although the drug is generally well-tolerated, the daily dosage should initially be reduced in patients with moderate to severe renal impairment (CrCl < 50 mL/min). If necessary, the daily dosage may be increased with caution.

References

  1. McFayden ML, Folb PI, Miller R, et al "Pharmacokinetics of ranitidine in patients with chronic renal failure." Eur J Clin Pharmacol 25 (1983): 347-51
  2. Meffin PJ, Grgurinovich N, Brooks PM, et al "Ranitidine disposition in patients with renal impairment." Br J Clin Pharmacol 16 (1983): 731-4
  3. Kopitar Z, Cvelbar P, Zorz M, et al "Pharmacokinetics of ranitidine in adult patients with end stage renal disease after single and multiple dosing." Acta Pharm Juglosl 37 (1987): 371-9
View all 9 references

ranitidine drug Interactions

There are 297 drug interactions with ranitidine

ranitidine alcohol/food Interactions

There is 1 alcohol/food interaction with ranitidine

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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