Ranitidine Disease Interactions
There are 6 disease interactions with ranitidine.
H2 antagonists (applies to ranitidine) GI bleeding
Major Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Hemorrhage
Histamine H2 receptor antagonists should not be used in the presence of vomit with blood, or bloody or black stools. These might be serious conditions and the diagnosis needs to be ruled out.
Ranitidine (applies to ranitidine) porphyria
Major Potential Hazard, Moderate plausibility.
Ranitidine may rarely precipitate acute porphyria attacks and should be avoided in patients with a history of acute porphyria.
Ranitidine (applies to ranitidine) hemodialysis
Moderate Potential Hazard, High plausibility.
Ranitidine is partially removed by hemodialysis and should be administered after dialysis.
Ranitidine (applies to ranitidine) liver disease
Moderate Potential Hazard, Low plausibility.
Ranitidine is partially metabolized by the liver. Although dosage reductions are generally not necessary, therapy with ranitidine should be administered cautiously in patients with liver disease. Elevated ALT (SGPT) has been observed in patients receiving ranitidine intravenously at dosages greater than those normally recommended for 5 days or more.
Ranitidine (applies to ranitidine) PKU
Moderate Potential Hazard, High plausibility. Applicable conditions: Phenylketonuria
Zantac (brand of ranitidine) 150 EFFERdose tablets and granules both contain 16.84 mg of phenylalanine per each 150 mg of ranitidine. The phenylalanine content should be considered when these products are used in patients who must restrict their intake of phenylalanine (i.e. phenylketonurics).
Ranitidine (applies to ranitidine) renal dysfunction
Moderate Potential Hazard, High plausibility.
Ranitidine is primarily eliminated by the kidney. Although the drug is generally well-tolerated, the daily dosage should initially be reduced in patients with moderate to severe renal impairment (CrCl < 50 mL/min). If necessary, the daily dosage may be increased with caution.
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Ranitidine drug interactions
There are 150 drug interactions with ranitidine.
Ranitidine alcohol/food interactions
There is 1 alcohol/food interaction with ranitidine.
More about ranitidine
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- During pregnancy
- Drug class: H2 antagonists
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Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
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