Intal Disease Interactions
There is 1 disease interaction with Intal (cromolyn).
Cromolyn (applies to Intal) renal/liver disease
Minor Potential Hazard, Low plausibility. Applicable conditions: Renal Dysfunction
Systemically absorbed cromolyn is eliminated almost equally by renal and biliary routes. Although less than 1% of an orally ingested dose and approximately 8% of an orally inhaled dose is systemically available, the manufacturers recommend that a dosage reduction be considered in patients with impaired renal or hepatic function.
References (7)
- Richards R, Dickson CR, Renwick AG, Lewis RA, Holgate ST (1987) "Absorption and disposition kinetics of cromolyn sodium and the influence of inhalation technique." J Pharmacol Exp Ther, 241, p. 1028-32
- Rosenberg JL, Edlow D, Sneider R (1978) "Liver disease and vasculitis in a patient taking cromolyn." Arch Intern Med, 138, p. 989-91
- Neale MG, Brown K, Hodder RW, Auty RM (1986) "The pharmacokinetics of sodium cromoglycate in man after intravenous and inhalation administration." Br J Clin Pharmacol, 22, p. 373-82
- Fuller RW, Collier JG (1983) "The pharmacokinetic assessment of sodium cromoglycate." J Pharm Pharmacol, 35, p. 289-92
- Walker SR, Evans ME, Richards AJ, Paterson JW (1972) "The fate of [14C]disodium cromoglycate in man." J Pharm Pharmacol, 24, p. 525-31
- (2001) "Product Information. Intal (cromolyn)." Rhone Poulenc Rorer
- (2001) "Product Information. Gastrocrom (cromolyn)." Rhone Poulenc Rorer
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Intal drug interactions
There is 1 drug interaction with Intal (cromolyn).
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- Reviews (3)
- Side effects
- Dosage information
- During pregnancy
- Drug class: mast cell stabilizers
- Breastfeeding
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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