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Intal (cromolyn) Disease Interactions

There is 1 disease interaction with Intal (cromolyn):


Cromolyn (Includes Intal) ↔ Renal/Liver Disease

Minor Potential Hazard, Low plausibility

Applies to: Liver Disease, Renal Dysfunction

Systemically absorbed cromolyn is eliminated almost equally by renal and biliary routes. Although less than 1% of an orally ingested dose and approximately 8% of an orally inhaled dose is systemically available, the manufacturers recommend that a dosage reduction be considered in patients with impaired renal or hepatic function.


  1. Fuller RW, Collier JG "The pharmacokinetic assessment of sodium cromoglycate." J Pharm Pharmacol 35 (1983): 289-92
  2. "Product Information. Gastrocrom (cromolyn)." Rhone-Poulenc Rorer, Collegeville, PA.
  3. Rosenberg JL, Edlow D, Sneider R "Liver disease and vasculitis in a patient taking cromolyn." Arch Intern Med 138 (1978): 989-91
  4. Walker SR, Evans ME, Richards AJ, Paterson JW "The fate of [14C]disodium cromoglycate in man." J Pharm Pharmacol 24 (1972): 525-31
  5. Neale MG, Brown K, Hodder RW, Auty RM "The pharmacokinetics of sodium cromoglycate in man after intravenous and inhalation administration." Br J Clin Pharmacol 22 (1986): 373-82
  6. Richards R, Dickson CR, Renwick AG, Lewis RA, Holgate ST "Absorption and disposition kinetics of cromolyn sodium and the influence of inhalation technique." J Pharmacol Exp Ther 241 (1987): 1028-32
  7. "Product Information. Intal (cromolyn)." Rhone-Poulenc Rorer, Collegeville, PA.
View all 7 references

Intal (cromolyn) drug Interactions

There is 1 drug interaction with Intal (cromolyn)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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