trimethobenzamide (Oral route)
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Antiemetic
Pharmacologic Class: Anticholinergic
Uses For trimethobenzamide
Trimethobenzamide is used to treat nausea and vomiting after surgery. It is also used to treat nausea caused by gastroenteritis.
trimethobenzamide is available only with your doctor's prescription.
Before Using trimethobenzamide
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For trimethobenzamide, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to trimethobenzamide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Because of trimethobenzamide's toxicity, use in children is not recommended. Safety and efficacy have not been established.
Appropriate studies on the relationship of age to the effects of trimethobenzamide have not been performed in the geriatric population. However, elderly patients are more likely to have unwanted side effects and age-related kidney disease, which may require an adjustment in the dose for patients receiving trimethobenzamide.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking trimethobenzamide, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using trimethobenzamide with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of trimethobenzamide. Make sure you tell your doctor if you have any other medical problems, especially:
- Brain disease (eg, encephalopathy, Reye's syndrome) or
- Electrolyte imbalance (high or low levels of minerals in the blood)—Use with caution. May cause side effects to become worse.
- Kidney disease—Use with caution. The effects of trimethobenzamide may be increased because of slower removal from the body.
- Liver disease—Use with caution. May make this condition worse.
Proper Use of trimethobenzamide
Take trimethobenzamide exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.
The dose of trimethobenzamide will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of trimethobenzamide. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (capsules):
- For nausea and vomiting after surgery and nausea caused by gastroenteritis:
- Adults—300 milligrams (mg) 3 or 4 times a day. Your doctor may adjust your dose as needed and tolerated.
- Children—Use and dose must be determined by your doctor.
- For nausea and vomiting after surgery and nausea caused by gastroenteritis:
If you miss a dose of trimethobenzamide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions While Using trimethobenzamide
It is very important that your doctor check your progress at regular visits to make sure that trimethobenzamide is working properly. Blood and urine tests may be needed to check for unwanted effects.
Trimethobenzamide will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicines for hay fever, other allergies, or colds, sedatives, tranquilizers, sleeping medicines, prescription or narcotic pain medicines, barbiturates or seizure medicines, muscle relaxants, or anesthetics, including some dental anesthetics. Check with your doctor before taking any of these medicines while you are using trimethobenzamide.
trimethobenzamide may cause extrapyramidal symptoms. Check with your doctor right away if you have difficulty in speaking, drooling, loss of balance control, muscle trembling, jerking, or stiffness, restlessness, shuffling walk, stiffness of the limbs, twisting movements of the body, or uncontrolled movements, especially of the face, neck, and back.
trimethobenzamide may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Make sure you know how you react to trimethobenzamide before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.
Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
trimethobenzamide Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:Incidence not known
- Abdominal or stomach pain
- change in consciousness
- clay-colored stools
- confusion about identity, place, and time
- dark urine
- difficulty swallowing
- feeling sad or empty
- lack of appetite
- loss of balance control
- loss of consciousness
- loss of interest or pleasure
- mask-like face
- pale skin
- severe spasm where the head and heels are bent backward and the body arched forward
- shuffling walk
- slowed movements of the arms and legs
- slurred speech
- sore throat
- swelling of the arms, face, legs, lips, tongue, or throat
- tic-like (jerky) movements of the head, face, mouth, and neck
- trembling and shaking of the fingers and hands
- trouble concentrating
- trouble sleeping
- unpleasant breath odor
- unusual bruising or bleeding
- unusual tiredness or weakness
- vomiting of blood
- yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Incidence not known
- Blurred vision
- muscle cramps
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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More about trimethobenzamide
- Side Effects
- During Pregnancy
- Dosage Information
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- Drug Interactions
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- Drug class: anticholinergic antiemetics