Generic Name: naldemedine (Oral route)
Medically reviewed by Drugs.com. Last updated on Jan 18, 2020.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Gastrointestinal Agent
Pharmacologic Class: Opioid Antagonist
Uses for Symproic
Naldemedine is used to treat constipation that is caused by opioids (narcotic pain medicines) in adults with long-lasting pain that is not caused by cancer, or in patients with long-lasting pain caused by a previous cancer or its treatment who do not need weekly increases in opioid dosage.
This medicine is available only with your doctor's prescription.
Before using Symproic
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of naldemedine in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of naldemedine in the elderly. However, elderly patients are more sensitive to the effects of this medicine than younger adults.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Interactions with food/tobacco/alcohol
Other medical problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Crohn's disease or
- Diverticulitis or
- Ogilvie syndrome or
- Peptic ulcer or
- Stomach or bowel cancer—May increase risk for more serious side effects.
- Patients at increased risk of stomach blockage or
- Stomach or bowel blockage, known or suspected—Should not be used in patients with these conditions.
Proper use of Symproic
Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.
This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.
Swallow the tablet whole. Do not crush, break, or chew it. You may take it with or without food.
It is important that you take this medicine together with narcotic pain medicines. If you stop taking narcotic pain medicines, you should also stop taking naldemedine.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
- For oral dosage form (tablets):
- For constipation caused by opioids:
- Adults—0.2 milligrams (mg) once a day for at least 4 weeks (with narcotic pain medicines).
- Children—Use and dose must be determined by your doctor.
- For constipation caused by opioids:
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions while using Symproic
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to decide if you should continue to take it.
This medicine may cause a tear (perforation) in your stomach or bowels. Check with your doctor right away if you have a severe stomach pain that does not go away.
This medicine may cause withdrawal symptoms. Tell your doctor right away if you have increased sweating, chills, increased tearing, redness on the face, neck, arms, and upper chest, feeling cold, abdominal or stomach pain, diarrhea, nausea, and vomiting.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.
Symproic side effects
Check with your doctor immediately if any of the following side effects occur:
- stomach pain
- Fast heartbeat
- hives, itching, or rash
- joint pain, stiffness, or swelling
- loss of appetite
- redness of the skin
- swelling of the eyelids, face, lips, hands, or feet
- tightness in the chest
- troubled breathing or swallowing
Incidence not known
- Bloody, black, or tarry stools
- feeling cold
- increased sweating
- redness on the face, neck, arms, and upper chest
- severe abdominal or stomach pain, cramping, or burning
- vomiting of material that looks like coffee grounds, severe and continuous
Incidence not known
- Fast, pounding, or irregular heartbeat or pulse
- increased tearing
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More about Symproic (naldemedine)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- 16 Reviews
- Drug class: peripheral opioid receptor antagonists
- FDA Approval History