Generic Name: dexlansoprazole (Oral route)
Medically reviewed on Oct 4, 2018
Commonly used brand name(s)
In the U.S.
- Dexilant SoluTab
Available Dosage Forms:
- Capsule, Delayed Release
- Tablet Disintegrating, Delayed Release
Therapeutic Class: Gastric Acid Secretion Inhibitor
Pharmacologic Class: Proton Pump Inhibitor
Uses For Dexilant
Dexlansoprazole is used to treat certain conditions in which there is too much acid in the stomach. It is used to treat erosive esophagitis or "heartburn" caused by gastroesophageal reflux disease (GERD), a condition where the acid in the stomach washes back up into the esophagus.
Dexlansoprazole is a proton pump inhibitor (PPI). It works by decreasing the amount of acid produced by the stomach.
This medicine is available only with your doctor's prescription.
On October 17, 2017, Dexilant Solutab® (delayed-release disintegrating tablets) was withdrawn from the US market. Dexilant® and Kapidex® (delayed-release capsules) are still available.
Before Using Dexilant
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of dexlansoprazole in children younger than 12 years of age. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dexlansoprazole in the elderly. However, elderly patients are more sensitive to the effects of this medicine than younger adults.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Mycophenolate Mofetil
- Mycophenolic Acid
- Secretin Human
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Diarrhea or
- Hypomagnesemia (low magnesium in the blood), history of or
- Osteoporosis (bone problem) or
- Seizures, history of or
- Systemic lupus erythematosus (SLE)—Use with caution. May make these conditions worse.
- Liver disease, moderate—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Proper Use of dexlansoprazole
This section provides information on the proper use of a number of products that contain dexlansoprazole. It may not be specific to Dexilant. Please read with care.
Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
This medicine comes with a Medication Guide and patient instructions. Read and follow the instructions carefully. Ask your doctor if you have any questions.
If you are taking the delayed-release capsule:
- You may take this medicine with or without food.
- Swallow it whole. If you cannot swallow the capsule whole, you may open it and pour the contents into a tablespoon of applesauce. Swallow the mixture right away without chewing. Do not store the mixed medicine for later use.
- If Dexilant® is given through an oral syringe: Open the capsule and pour the medicine into a clean container with 20 milliliters (mL) of water. Use an oral syringe to draw up the water and granule mixture. Swirl the syringe gently to keep the granules from settling. Give the mixture directly into the mouth right away. Do not store the mixed medicine for later use. To rinse any leftover medicine in the syringe, refill the syringe with 10 mL of water, swirl gently and swallow the water. Repeat with an additional 10 mL of water.
- If Dexilant® is given through a feeding tube: Open the capsule and pour the medicine into a clean container with 20 mL of water. Get the mixed medicine into a catheter-tip syringe. Swirl the syringe gently to keep the granules from settling, and inject the medicine into the NG tube right away. Refill the syringe with the 10 mL of water. Swirl it gently, and inject it into the tube to rinse any leftover medicine through the tube. Repeat with an additional 10 mL of water.
Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (delayed-release capsules):
- For treatment of erosive esophagitis (EE):
- Adults and children 12 years of age and older—60 milligrams (mg) once a day for up to 8 weeks. To prevent erosive esophagitis from coming back and for relief of heartburn, your doctor may want you to take 30 mg once a day for up to 6 months.
- Children younger than 12 years of age—Use and dose must be determined by your doctor.
- For treatment of gastroesophageal reflux disease (GERD):
- Adults and children 12 years of age and older—30 milligrams (mg) once a day for 4 weeks.
- Children younger than 12 years of age—Use and dose must be determined by your doctor.
- For treatment of erosive esophagitis (EE):
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions While Using Dexilant
It is important that your doctor check your or your child's progress at regular visits. This will allow your doctor to see if this medicine is working properly and to decide if you should continue to take it. Blood, urine, and other laboratory tests may be needed to check for unwanted effects.
Do not take this medicine if you are also using products that contain rilpivirine (Complera®, Edurant®).
This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Check with your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.
Check with your doctor right away if you have a fever, joint pain, skin rash, swelling of the body, feet, or ankles, or unusual weight gain after taking this medicine. These could be symptoms of a serious kidney problem called acute interstitial nephritis.
Taking this medicine for a long time may make it harder for your body to absorb vitamin B12. Tell your doctor if you have concerns about vitamin B12 deficiency.
Check with your doctor right away if you have watery stool that does not go away, stomach pain, and fever while taking this medicine.
Dexlansoprazole may increase your risk of having fractures of the hip, wrist, and spine. This is more likely if you are 50 years of age and older, if you receive high doses of this medicine, or use it for one year or more.
Cutaneous or systemic lupus erythematosus may occur or get worse in patients receiving a PPI. Call your doctor right away if you have joint pain or a skin rash on your cheeks or arms that gets worse when exposed to the sun.
This medicine may cause hypomagnesemia (low magnesium in the blood). This is more likely to occur if you are taking this medicine for more than 1 year, or if you are taking this medicine together with digoxin (Lanoxin®) or certain diuretics (water pills). Check with your doctor right away if you have convulsions (seizures), fast, racing, or uneven heartbeat, muscle spasms (tetany), tremors, or unusual tiredness or weakness.
This medicine may increase your risk for fundic gland polyps (abnormal tissue growth in the upper part of your stomach). This is more likely if you are receiving this medicine for more than 1 year. Talk to your doctor if you have concerns.
Do not stop taking this medicine without first checking with your doctor, or unless told to do so by your doctor.
Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription (eg, atazanavir, Reyataz®) or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.
Dexilant Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
- Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- chest pain or discomfort
- chest tightness or heaviness
- continuing stomach pain
- difficult or labored breathing
- fast, irregular, pounding, or racing heartbeat or pulse
- incoherent speech
- joint pain, stiffness, or swelling
- lightheadedness, dizziness, or fainting
- muscle pain, cramps, or weakness
- numbness or tingling in the hands, feet, or lips
- pain or discomfort in the arms, jaw, leg, back, or neck
- pounding in the ears
- rash, hives
- shakiness in the legs, arms, hands, or feet
- swelling of the eyelids, face, lips, hands, or feet
- swollen, painful, or tender lymph glands in the neck, armpit, or groin
- unusual bleeding or bruising
- vomiting of blood or material that looks like coffee grounds
- watery or bloody diarrhea
Incidence not known
- Blistering, peeling, or loosening of the skin
- muscle spasms (tetany) or twitching
- red skin lesions, often with a purple center
- red, irritated eyes
- sores, ulcers, or white spots in the mouth or on the lips
- swelling of the body, feet, or ankles
- unusual weight gain
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Abnormal dreams
- body aches or pain
- bloated or full feeling
- burning or itching around the anus
- change in taste or bad, unusual, or unpleasant (after) taste
- continuing ringing or buzzing or other unexplained noise in the ears
- difficult or painful urination
- difficulty with moving
- ear congestion
- ear pain
- excess air or gas in the stomach or bowels
- feeling of constant movement of self or surroundings
- loss in sexual ability, desire, drive, or performance
- loss of voice
- metallic taste
- muscle or bone pain
- nasal congestion
- passing gas
- redness of the face, neck, arms, and occasionally, upper chest
- runny nose
- sensation of spinning
- sore throat
- trouble sleeping
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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- Drug class: proton pump inhibitors