Comparing Wellbutrin vs Zoloft
Wellbutrin | Zoloft |
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Wellbutrin (bupropion) | Zoloft (sertraline) |
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Prescription only
Wellbutrin may be used in the treatment of depression; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black box warning because it may cause... View more |
Prescription only
Zoloft is a brand name for sertraline which is an effective antidepressant with less potential for drowsiness than many other antidepressants. It belongs to the group of medicines called selective... View more |
Related suggestions Depression
Major Depressive Disorder
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More about Wellbutrin (bupropion) | More about Zoloft (sertraline) | ||||||||
Ratings & Reviews | |||||||||
Wellbutrin has an average rating of 6.8 out of 10 from a total of 748 ratings on Drugs.com. 59% of reviewers reported a positive effect, while 23% reported a negative effect. |
Zoloft has an average rating of 7.2 out of 10 from a total of 1942 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 19% reported a negative effect. |
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Drug Class | |||||||||
Side Effects | |||||||||
See also: Wellbutrin side effects in more detail. |
See also: Zoloft side effects in more detail. |
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Generic Availability | |||||||||
Pricing and Coupons * Prices are without insurance | |||||||||
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Zoloft prices |
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Dosage Form(s) Available | |||||||||
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Brand Names | |||||||||
Other bupropion brands include: Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL |
N/A |
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Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||
30 hours |
66 hours |
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CSA Schedule ** View glossary of terms | |||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||
A total of 497 drugs are known to interact with Wellbutrin:
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A total of 656 drugs are known to interact with Zoloft:
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Alcohol/Food/Lifestyle Interactions | |||||||||
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Disease Interactions | |||||||||
First Approval Date | |||||||||
December 30, 1985 |
December 30, 1991 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||
N/A |
N/A |
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More Information | |||||||||
Patient resources | |||||||||
Professional Resources | |||||||||
Related Treatment Guide | |||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.