Comparing Wellbutrin vs Zoloft
| Wellbutrin (bupropion) | Zoloft (sertraline) |
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| Wellbutrin (bupropion) | Zoloft (sertraline) |
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Prescription only
Wellbutrin may be used in the treatment of depression; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black box warning because it may cause... View more |
Prescription only
Zoloft is a brand name for sertraline which is an effective antidepressant with less potential for drowsiness than many other antidepressants. It belongs to the group of medicines called selective... View more |
Related suggestions Depression
Major Depressive Disorder
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| More about Wellbutrin (bupropion) | More about Zoloft (sertraline) | ||||||||
| Ratings & Reviews | |||||||||
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Wellbutrin has an average rating of 6.8 out of 10 from a total of 757 ratings on Drugs.com. 58% of reviewers reported a positive effect, while 23% reported a negative effect. |
Zoloft has an average rating of 7.3 out of 10 from a total of 1972 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 18% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||
View all Wellbutrin side effects |
View all Zoloft side effects |
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| Drug Class | |||||||||
| Generic Availability | |||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Zoloft prices |
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| Dosage Forms | |||||||||
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| Brand Names | |||||||||
| Other bupropion brands include: Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||
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30 hours |
66 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||
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A total of 559 drugs are known to interact with Wellbutrin:
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A total of 673 drugs are known to interact with Zoloft:
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| Alcohol/Food/Lifestyle Interactions | |||||||||
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| Disease Interactions | |||||||||
| First Approval Date | |||||||||
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December 30, 1985 |
December 30, 1991 |
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| WADA Class View classifications | |||||||||
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N/A |
N/A |
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| More Information | |||||||||
| Patient Resources | |||||||||
| Professional Resources | |||||||||
| Related Treatment Guide | |||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.