Comparing Wellbutrin vs Zoloft
| Wellbutrin (bupropion) | Zoloft (sertraline) |
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| Wellbutrin (bupropion) | Zoloft (sertraline) |
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Prescription only
Wellbutrin may be used in the treatment of depression; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black box warning because it may cause... View more |
Prescription only
Zoloft is a brand name for sertraline which is an effective antidepressant with less potential for drowsiness than many other antidepressants. It belongs to the group of medicines called selective... View more |
Related suggestions Depression
Major Depressive Disorder
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| More about Wellbutrin (bupropion) | More about Zoloft (sertraline) | ||||||||
| Ratings & Reviews | |||||||||
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Wellbutrin has an average rating of 6.8 out of 10 from a total of 756 ratings on Drugs.com. 58% of reviewers reported a positive effect, while 23% reported a negative effect. |
Zoloft has an average rating of 7.3 out of 10 from a total of 1972 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 18% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||
View all Wellbutrin side effects |
View all Zoloft side effects |
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| Drug Class | |||||||||
| Generic Availability | |||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Zoloft prices |
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| Dosage Forms | |||||||||
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| Brand Names | |||||||||
| Other bupropion brands include: Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||
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30 hours |
66 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||
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A total of 559 drugs are known to interact with Wellbutrin:
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A total of 673 drugs are known to interact with Zoloft:
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| Alcohol/Food/Lifestyle Interactions | |||||||||
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| Disease Interactions | |||||||||
| First Approval Date | |||||||||
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December 30, 1985 |
December 30, 1991 |
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| WADA Class View classifications | |||||||||
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N/A |
N/A |
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| More Information | |||||||||
| Patient Resources | |||||||||
| Professional Resources | |||||||||
| Related Treatment Guide | |||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.