Comparing Effexor vs Wellbutrin

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Effexor (venlafaxine)	Wellbutrin (bupropion)	Enter another drug to compare

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Effexor (venlafaxine)	Wellbutrin (bupropion)	Enter another drug to compare
Prescription only Effexor is an antidepressant that may cause a discontinuation syndrome if abruptly stopped after long-term administration. Prescribed for Autism, Major Depressive Disorder, Depression, Bulimia... View more	Prescription only Wellbutrin may be used in the treatment of depression; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black box warning because it may cause... View more	Related suggestions Depression Bupropion Sertraline Cymbalta Lexapro Zoloft Fluoxetine Major Depressive Disorder Wellbutrin XL Zoloft Bupropion Lexapro Prozac Trintellix Popular comparisons Effexor vs citalopram Effexor vs Prozac Effexor vs Pristiq Effexor vs Trintellix Effexor vs Effexor XR Effexor vs Auvelity
More about (venlafaxine)	More about Wellbutrin (bupropion)
Ratings & Reviews
Effexor has an average rating of 5.8 out of 10 from a total of 490 ratings on Drugs.com. 44% of reviewers reported a positive effect, while 33% reported a negative effect.	Wellbutrin has an average rating of 6.8 out of 10 from a total of 761 ratings on Drugs.com. 59% of reviewers reported a positive effect, while 22% reported a negative effect.
View all 490 reviews	View all 761 reviews
Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.
Nausea (15.1%) Withdrawal (13.9%) Dizziness (13.1%) Headaches (9.0%) Anxiety (8.8%) Sweating (8.8%) Depression (8.4%) View all Effexor side effects	Anxiety (19.4%) Insomnia (13.9%) Headaches (7.9%) Irritability (6.4%) Sexual dysfunction (6.2%) Loss of appetite (6.0%) Depression (5.8%) View all Wellbutrin side effects
Drug Class
Serotonin-norepinephrine reuptake inhibitors	Miscellaneous antidepressants
Generic Availability
Lower cost generic approved	Lower cost generic approved
Pricing and Coupons * Prices are without insurance
We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.
Get free Discount Card	Get free Discount Card

Dosage Forms
N/A	Oral tablet
Brand Names
Other venlafaxine brands include: Effexor XR	Other bupropion brands include: Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.
4 hours	30 hours
CSA Schedule ¹ View glossary of CSA terms
N Not a controlled drug Is not subject to the Controlled Substances Act.	N Not a controlled drug Is not subject to the Controlled Substances Act.
Pregnancy Category
C Category C Risk cannot be ruled out See the full pregnancy warnings document.	C Category C Risk cannot be ruled out See the full pregnancy warnings document.
Drug Interactions
A total of 702 drugs are known to interact with Effexor: 152 major drug interactions (595 brand and generic names) 546 moderate drug interactions (2385 brand and generic names) 4 minor drug interactions (13 brand and generic names)	A total of 559 drugs are known to interact with Wellbutrin: 218 major drug interactions (952 brand and generic names) 336 moderate drug interactions (1875 brand and generic names) 5 minor drug interactions (16 brand and generic names)
Alcohol/Food/Lifestyle Interactions
Alcohol can increase the nervous system side effects of venlafaxine such as dizziness, drowsiness... View more	Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more
Disease Interactions
Depression Renal disease Renal/liver disease Mania Glaucoma Hypertension Hyponatremia Mania Seizures Urinary tract obstruction Weight loss	Suicidality Seizure disorders Angle closure glaucoma Liver disease Mixed/manic episode Renal dysfunction Weight loss
First Approval Date
N/A	December 30, 1985
WADA Class View classifications
N/A	N/A
More Information
Side effects Drug interactions Dosage Pregnancy warnings Breastfeeding warnings Drug images Support group	Side effects Drug interactions Dosage Pregnancy warnings Breastfeeding warnings Drug images Support group
Patient Resources
N/A	Wellbutrin uses
Professional Resources
Prescribing information	Prescribing information
Related Treatment Guide
Autism Major Depressive Disorder Depression Bulimia Postpartum Depression	Major Depressive Disorder Depression

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

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Comparing Effexor vs Wellbutrin

See also:

Auvelity

Abilify

Vraylar

Effexor XR

Risperdal

Geodon

Abilify Maintena

Aristada

Uzedy

Risperdal Consta

Further information

Comparing Effexor vs Wellbutrin

See also:

Further information

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