Trihexyphenidyl Alternatives Compared
| Trihexyphenidyl | Benztropine | Diphenhydramine |
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| Trihexyphenidyl | Benztropine | Diphenhydramine |
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Prescription only
Prescribed for Parkinson's Disease, Cerebral Spasticity, Extrapyramidal Reaction. Trihexyphenidyl may also be used for purposes not listed in this medication guide. |
Prescription only
Benztropine may be used to treat symptoms of Parkinson's disease or alleviate side effects that affect movement caused by antipsychotics. However, it may cause unwanted effects such as blurred... View more |
Prescription and OTC
Diphenhydramine is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side... View more |
Related suggestions Extrapyramidal Reaction
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| More about Trihexyphenidyl | More about Benztropine | More about Diphenhydramine | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Trihexyphenidyl has an average rating of 6.5 out of 10 from a total of 24 ratings on Drugs.com. 46% of reviewers reported a positive effect, while 25% reported a negative effect. |
Benztropine has an average rating of 6.8 out of 10 from a total of 36 ratings on Drugs.com. 58% of reviewers reported a positive effect, while 31% reported a negative effect. |
Diphenhydramine has an average rating of 5.5 out of 10 from a total of 542 ratings on Drugs.com. 42% of reviewers reported a positive effect, while 40% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||||||||||
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View all Trihexyphenidyl side effects |
View all Benztropine side effects |
View all Diphenhydramine side effects |
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| Drug Class | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Trihexyphenidyl prices |
View all Benztropine prices |
View all Diphenhydramine prices |
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| Dosage Forms | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Trihexy |
N/A |
Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Aurodryl Children's Allergy, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | ||||||||||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||||||||||
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4.1 hours |
N/A |
9.3 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category N
Not classified
See the full pregnancy warnings document. |
Category N
Not classified
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 337 drugs are known to interact with Trihexyphenidyl:
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A total of 346 drugs are known to interact with Benztropine:
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A total of 448 drugs are known to interact with Diphenhydramine:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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| First Approval Date | ||||||||||||||||||||||||||
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May 13, 1949 |
March 05, 1954 |
March 04, 1946 |
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| WADA Class View classifications | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| Related Treatment Guide | ||||||||||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.