Trihexyphenidyl Alternatives Compared
| Trihexyphenidyl | Benztropine | Amantadine |
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| Trihexyphenidyl | Benztropine | Amantadine |
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Prescription only
Prescribed for Parkinson's Disease, Cerebral Spasticity, Extrapyramidal Reaction. Trihexyphenidyl may also be used for purposes not listed in this medication guide. |
Prescription only
Benztropine is used as a supplementary treatment for all forms of Parkinson's disease or to help control extrapyramidal disorders (except tardive dyskinesia) due to neuroleptic drugs, such as... View more |
Prescription only
Amantadine may be used to treat dyskinesia or reduce the number of OFF episodes in those with Parkinson's disease (PD) OR in the treatment or prevention of Influenza A viral infection. Nausea... View more |
Related suggestions Extrapyramidal Reaction
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| More about Trihexyphenidyl | More about Benztropine | More about Amantadine | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Trihexyphenidyl has an average rating of 6.5 out of 10 from a total of 24 ratings on Drugs.com. 46% of reviewers reported a positive effect, while 25% reported a negative effect. |
Benztropine has an average rating of 6.8 out of 10 from a total of 39 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 28% reported a negative effect. |
Amantadine has an average rating of 6.9 out of 10 from a total of 56 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 20% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||||||||||
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View all Trihexyphenidyl side effects |
View all Benztropine side effects |
View all Amantadine side effects |
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| Drug Class | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Trihexyphenidyl prices |
View all Benztropine prices |
View all Amantadine prices |
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| Dosage Forms | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Trihexy |
N/A |
Gocovri, Osmolex ER | ||||||||||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||||||||||
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4.1 hours |
N/A |
19 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category N
Not classified
See the full pregnancy warnings document. |
Category N
Not classified
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 337 drugs are known to interact with Trihexyphenidyl:
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A total of 346 drugs are known to interact with Benztropine:
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A total of 131 drugs are known to interact with Amantadine:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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May 13, 1949 |
March 05, 1954 |
February 14, 1968 |
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| WADA Class View classifications | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient Resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.