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Amantadine Disease Interactions

There are 5 disease interactions with amantadine:

Major

Amantadine (Includes Amantadine) ↔ Psychoses/Depression

Severe Potential Hazard, Moderate plausibility

Applies to: Psychosis, Depression, History - Psychiatric Disorder, Alcoholism, Drug Abuse/Dependence

Amantadine may precipitate or exacerbate psychotic symptoms. Rarely, suicide attempts and suicidal ideation have also been reported, some of which occurred in patients with no prior history of psychiatric illness who were taking short courses of amantadine for influenza. Therapy with amantadine should be administered cautiously in patients with a history of psychiatric disorders, emotional instability, or substance abuse, and particularly if they are elderly. It may be prudent to refrain from dispensing large quantities of amantadine to these patients to prevent intentional overdose, which is potentially fatal.

References

  1. Millet VM, Dreisbach M, Bryson YJ "Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine." Antimicrob Agents Chemother 21 (1982): 1-4
  2. Millet VM, Dreisbach M, Bryson YJ "Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine." Antimicrob Agents Chemother 21 (1982): 1-4
  3. Hayden FG, Hoffman HE, Spyker DA "Differences in side effects of amantadine hydrochloride and rimantadine hydrochloride relate to differences in pharmacokinetics." Antimicrob Agents Chemother 23 (1983): 458-64
View all 15 references
Major

Amantadine (Includes Amantadine) ↔ Renal Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Renal Dysfunction

Amantadine is primarily eliminated by the kidney. Patients with renal impairment may be at greater risk for adverse effects from amantadine due to decreased drug clearance. Therapy with amantadine should be administered cautiously in patients with renal impairment. Dosage adjustments are recommended for patients with moderate to severe renal dysfunction.

References

  1. Wu MJ, Ing TS, Soung LS, Daugirdas JT, Hano JE, Gandhi VC "Amantadine hydrochloride pharmacokinetics in patients with impaired renal function." Clin Nephrol 17 (1982): 19-23
  2. Horadam VW, Sharp JG, Smilack JD, et al "Pharmacokinetics of amantadine hydrochloride in subjects with normal and impaired renal function." Ann Intern Med 94 (1981): 454-8
  3. Borison RL "Amantadine-induced psychosis in a geriatric patient with renal disease." Am J Psychiatry 136 (1979): 111-2
View all 6 references
Major

Amantadine (Includes Amantadine) ↔ Seizure Disorders

Severe Potential Hazard, Moderate plausibility

Applies to: Seizures

Amantadine may rarely precipitate or exacerbate seizure activity. Patients with epilepsy or predisposed to seizures should be monitored closely for increased seizure activity during therapy with amantadine.

References

  1. "Product Information. Symmetrel (amantadine)." DuPont Pharmaceuticals, Wilmington, DE.
  2. Ing TS, Daugirdas JT, Soung LS, et al "Toxic effects of amantadine in patients with renal failure." Can Med Assoc J 120 (1979): 695-8
  3. Millet VM, Dreisbach M, Bryson YJ "Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine." Antimicrob Agents Chemother 21 (1982): 1-4
View all 4 references
Moderate

Amantadine (Includes Amantadine) ↔ Chf/Edema

Moderate Potential Hazard, Moderate plausibility

Applies to: Congestive Heart Failure, Fluid Retention

Amantadine may occasionally cause peripheral edema and, rarely, congestive heart failure. Patients with edema or congestive heart failure should be monitored closely for exacerbation of their condition. Dosage adjustments may be necessary.

References

  1. "Product Information. Symmetrel (amantadine)." DuPont Pharmaceuticals, Wilmington, DE.
  2. Vale JA, Maclfan KS "Amantadine-induced heart-failure." Lancet 1 (1977): 548
Moderate

Amantadine (Includes Amantadine) ↔ Hypotension

Moderate Potential Hazard, Moderate plausibility

Applies to: Hypotension

Amantadine may occasionally cause orthostatic hypotension. Patients with hypotension should be monitored for exacerbation of their condition during therapy with amantadine. Dosage adjustments may be necessary, and patients should be advised not to rise abruptly from a sitting or recumbent position.

References

  1. "Product Information. Symmetrel (amantadine)." DuPont Pharmaceuticals, Wilmington, DE.

amantadine drug Interactions

There are 439 drug interactions with amantadine

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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