Comparing Spironolactone vs Tretinoin Topical

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Spironolactone	Tretinoin topical	Enter another drug to compare

Spironolactone

Tretinoin topical

Prescription only

Spironolactone is a diuretic that may be used to remove excess fluid (edema) from the body, lower blood pressure, or treat hyperaldosteronism. It does not cause potassium loss from the body; however... View more

Prescription only

Prescribed for Photoaging of the Skin, Lichen Sclerosus, Acne, Necrobiosis Lipoidica Diabeticorum. Tretinoin topical may also be used for purposes not listed in this medication guide.

More about Spironolactone

More about Tretinoin topical

Ratings & Reviews

Spironolactone has an average rating of 6.9 out of 10 from a total of 703 ratings on Drugs.com. 58% of reviewers reported a positive effect, while 24% reported a negative effect.

Tretinoin topical has an average rating of 7.7 out of 10 from a total of 493 ratings on Drugs.com. 71% of reviewers reported a positive effect, while 14% reported a negative effect.

View all 703 reviews

View all 493 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Acne (11.4%)
Dizziness (8.0%)
Hair loss (7.1%)
Weight gain (5.5%)
Headaches (5.1%)
Tiredness (4.4%)
Fatigue (4.3%)

View all Spironolactone side effects

Peeling (23.7%)
Acne (21.7%)
Dryness (13.8%)
Dry skin (11.2%)
Redness (9.5%)
Burning (7.9%)
Pain (4.1%)

View all Tretinoin topical side effects

Drug Class

Topical acne agents

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	100 each
Strength	25 mg
Per unit^*	$0.23 - $0.25
Cost^*	$23.10 - $25.17

View all Spironolactone prices

Quantity	20 gram(s)
Strength	0.025%
Per unit^*	$2.03
Cost^*	$40.60

View all Tretinoin topical prices

Get free Discount Card

Dosage Forms

Oral suspension
Oral tablet

Topical cream
Topical gel

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

37 hours

N/A

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 382 drugs are known to interact with Spironolactone:

51 major drug interactions (248 brand and generic names)
311 moderate drug interactions (1490 brand and generic names)
20 minor drug interactions (145 brand and generic names)

A total of 12 drugs are known to interact with Tretinoin topical:

1 major drug interactions (2 brand and generic names)
11 moderate drug interactions (342 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Spironolactone and alcohol may have additive effects in lowering your blood pressure. You may... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions

First Approval Date

January 21, 1960

January 26, 1973

WADA Class View classifications

S5 - Diuretics and Other Masking Agents

N/A

More Information

Patient Resources

Spironolactone uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Spironolactone vs Tretinoin Topical

See also:

Jardiance

Farxiga

Ozempic

Lasix

Entresto

Coreg

Norvasc

Aldactone

Coumadin

Bumex

Further information

Comparing Spironolactone vs Tretinoin Topical

See also:

Further information

Compare Drugs