Comparing Naproxen vs Amitriptyline
Naproxen | Amitriptyline |
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Naproxen | Amitriptyline |
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Prescription and OTC
Naproxen is effective for the short-term relief of pain and inflammation associated with arthritis, gout, menstruation, and tendonitis; however, like other NSAIDs, it has the potential to adversely... View more |
Prescription only
Amitriptyline is an effective antidepressant but it may cause drowsiness initially and a withdrawal syndrome with abrupt discontinuation. It may be used off-label to treat other conditions such as... View more |
Related suggestions Headache
Dysautonomia
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More about Naproxen | More about Amitriptyline | ||||||||||||||||
Ratings & Reviews | |||||||||||||||||
Naproxen has an average rating of 6.9 out of 10 from a total of 681 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 24% reported a negative effect. |
Amitriptyline has an average rating of 7.6 out of 10 from a total of 1779 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 16% reported a negative effect. |
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Drug Class | |||||||||||||||||
Side Effects | |||||||||||||||||
See also: naproxen side effects in more detail. |
See also: amitriptyline side effects in more detail. |
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Generic Availability | |||||||||||||||||
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all naproxen prices |
View all amitriptyline prices |
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Dosage Forms Available | |||||||||||||||||
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Brand Names | |||||||||||||||||
Aflaxen, Aleve, Aleve Back and Muscle Pain, All Day Pain Relief, All Day Relief, Anaprox-DS, Comfort Pac with Naproxen, EC-Naprosyn, Flanax Pain Reliever, Midol Extended Relief, Naprelan, Naprosyn, Naproxen Sodium DS, Pamprin All Day Relief View more |
N/A |
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Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
18 hours |
16 hours |
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CSA Schedule ** View glossary of terms | |||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||||||||||
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||||||||||
A total of 431 drugs are known to interact with naproxen:
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A total of 709 drugs are known to interact with amitriptyline:
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Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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Disease Interactions | |||||||||||||||||
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First Approval Date | |||||||||||||||||
March 11, 1976 |
April 07, 1961 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
N/A |
N/A |
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More Information | |||||||||||||||||
Patient resources | |||||||||||||||||
Professional Resources | |||||||||||||||||
Related Treatment Guide | |||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.