Comparing Estradiol vs Premarin Vaginal

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Estradiol	Premarin Vaginal (conjugated estrogens)	Enter another drug to compare

Estradiol

Premarin Vaginal (conjugated estrogens)

Prescription only

Estradiol is a synthetic form of estrogen that may be given for several different indications, including the relief of menopausal symptoms or low estrogen levels caused by other conditions. Its use... View more

Prescription only

Prescribed for Atrophic Vaginitis, Atrophic Urethritis, Postmenopausal Symptoms. Premarin Vaginal may also be used for purposes not listed in this medication guide.

More about Estradiol

More about Premarin Vaginal (conjugated estrogens)

Ratings & Reviews

Estradiol has an average rating of 5.8 out of 10 from a total of 590 ratings on Drugs.com. 46% of reviewers reported a positive effect, while 37% reported a negative effect.

Premarin Vaginal has an average rating of 7.3 out of 10 from a total of 21 ratings on Drugs.com. 62% of reviewers reported a positive effect, while 19% reported a negative effect.

View all 590 reviews

View all 21 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Hot flashes (17.5%)
Itching (7.1%)
Night sweats (6.1%)
Headaches (5.3%)
Insomnia (5.3%)
Mood swings (4.2%)
Rash (4.1%)

View all Estradiol side effects

View all Premarin Vaginal side effects

Drug Class

Estrogens

Generic Availability

Lower cost generic

N/A

Pricing and Coupons * Prices are without insurance

Quantity	30 tablet
Strength	1 mg
Per unit^*	$0.54
Cost^*	$16.14

View all Estradiol prices

Quantity	30 gram(s)
Strength	0.625 mg/g
Per unit^*	$16.73
Cost^*	$501.97

View all Premarin Vaginal prices

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Dosage Forms

Intramuscular solution
Oral tablet
Transdermal gel

Vaginal cream

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

16 hours

8 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Drug Interactions

A total of 390 drugs are known to interact with Estradiol:

34 major drug interactions (84 brand and generic names)
336 moderate drug interactions (1246 brand and generic names)
20 minor drug interactions (98 brand and generic names)

A total of 210 drugs are known to interact with Premarin Vaginal:

33 major drug interactions (82 brand and generic names)
161 moderate drug interactions (685 brand and generic names)
16 minor drug interactions (60 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions

First Approval Date

July 23, 1975

N/A

WADA Class View classifications

N/A

More Information

Patient Resources

Estradiol uses

Premarin Vaginal uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Estradiol vs Premarin Vaginal

See also:

Botox

Myrbetriq

Gemtesa

Fosamax

Premarin

Reclast

Estrace

Provera

Eligard

Depo Provera

Further information

Comparing Estradiol vs Premarin Vaginal

See also:

Further information

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