Comparing Enbrel vs Otezla
| Enbrel | Otezla |
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| Enbrel (etanercept) | Otezla (apremilast) |
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Prescription only
Enbrel is a subcutaneous injection that is usually self-administered once or twice a week for inflammatory conditions such as rheumatoid arthritis, psoriasis, psoriatic arthritis, or ankylosing... View more |
Prescription only
Otezla is a PDE4 inhibitor that may be used to treat plaque psoriasis, psoriatic arthritis, and oral ulcers associated with Behçet’s Disease. It has been associated with severe diarrhea, nausea, and v... View more |
Related suggestions Psoriatic Arthritis
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| More about Enbrel (etanercept) | More about Otezla (apremilast) | ||||||||||||||||
| Generic Status | |||||||||||||||||
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No lower-cost generic available |
No lower-cost generic available |
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| Ratings & Reviews | |||||||||||||||||
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Enbrel has an average rating of 7.8 out of 10 from a total of 299 ratings on Drugs.com. 72% of reviewers reported a positive effect, while 13% reported a negative effect. |
Otezla has an average rating of 5.0 out of 10 from a total of 410 ratings on Drugs.com. 34% of reviewers reported a positive effect, while 42% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
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Common side effects include:
See also: Enbrel side effects in more detail. |
Common side effects include:
See also: Otezla side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Enbrel prices |
View all Otezla prices |
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| Dosage Form(s) Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other etanercept brands include: Erelzi, Eticovo |
N/A |
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| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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300 hours |
9 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 434 drugs are known to interact with Enbrel:
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A total of 78 drugs are known to interact with Otezla:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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November 02, 1998 |
March 21, 2014 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
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N/A |
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| Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.