Comparing Enbrel vs Humira

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Enbrel (etanercept)	Humira (adalimumab)	Enter another drug to compare

Enbrel (etanercept)

Humira (adalimumab)

Prescription only

Enbrel is a subcutaneous injection that is usually self-administered once or twice a week for inflammatory conditions such as rheumatoid arthritis, psoriasis, psoriatic arthritis, or ankylosing... View more

Prescription only

Humira is a TNF-alfa inhibitor that may be used to treat a wide range of different inflammatory conditions, such as Rheumatoid Arthritis, psoriasis, ankylosing spondylitis, Crohn's disease, and... View more

More about Enbrel (etanercept)

More about Humira (adalimumab)

Ratings & Reviews

Enbrel has an average rating of 7.7 out of 10 from a total of 306 ratings on Drugs.com. 71% of reviewers reported a positive effect, while 14% reported a negative effect.

Humira has an average rating of 6.4 out of 10 from a total of 701 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 31% reported a negative effect.

View all 306 reviews

View all 701 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Pain (9.2%)
Swelling (4.9%)
Allergic reaction (2.6%)
Fatigue (2.6%)
Nausea (2.6%)
Injection site pain (2.3%)
Joint pain (2.3%)

View all Enbrel side effects

Pain (10.7%)
Headaches (4.7%)
Fatigue (4.4%)
Psoriasis (4.4%)
Rash (4.3%)
Tiredness (3.6%)
Itching (3.3%)

View all Humira side effects

Drug Class

Generic Availability

N/A

Pricing and Coupons * Prices are without insurance

Quantity	4 mL
Strength	50 mg/mL
Per unit^*	$2,179.60
Cost^*	$8,718.40

View all Enbrel prices

Quantity	2 kit
Strength	40 mg/0.8 mL
Per unit^*	$3,700.02
Cost^*	$7,400.03

View all Humira prices

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Dosage Forms

Subcutaneous kit
Subcutaneous solution

Subcutaneous kit

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

300 hours

480 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category B No proven risk in humans

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Drug Interactions

A total of 438 drugs are known to interact with Enbrel:

300 major drug interactions (877 brand and generic names)
129 moderate drug interactions (377 brand and generic names)
9 minor drug interactions (37 brand and generic names)

A total of 553 drugs are known to interact with Humira:

300 major drug interactions (869 brand and generic names)
244 moderate drug interactions (942 brand and generic names)
9 minor drug interactions (37 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions

First Approval Date

November 02, 1998

December 31, 2002

WADA Class View classifications

N/A

More Information

Patient Resources

Enbrel uses

Humira uses

Professional Resources

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Enbrel vs Humira

See also:

Skyrizi

Stelara

Otezla

Taltz

Vtama

Celebrex

Humira

Rinvoq

Plaquenil

Medrol

Further information

Comparing Enbrel vs Humira

See also:

Further information

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