Depen Alternatives Compared
Depen | Methotrexate | Sulfasalazine |
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Depen (penicillamine) | Methotrexate | Sulfasalazine |
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Prescription only
Prescribed for Rheumatoid Arthritis, Wilson's Disease, Cystinuria. Depen may also be used for purposes not listed in this medication guide. |
Prescription only
Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
Prescription only
Prescribed for Alopecia, Crohn's Disease, Crohn's Disease - Active, Inflammatory Bowel Disease, Crohn's Disease - Maintenance, Juvenile Rheumatoid Arthritis, Lymphocytic Colitis, Psoriatic Arthritis... View more |
Related suggestions Rheumatoid Arthritis
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More about Depen (penicillamine) | More about Methotrexate | More about Sulfasalazine | ||||||||||||||||||||||||
Ratings & Reviews | ||||||||||||||||||||||||||
Be the first to share your experience with this drug. |
Methotrexate has an average rating of 6.6 out of 10 from a total of 332 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 23% reported a negative effect. |
Sulfasalazine has an average rating of 6.0 out of 10 from a total of 190 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 34% reported a negative effect. |
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Drug Class | ||||||||||||||||||||||||||
Side Effects | ||||||||||||||||||||||||||
See also: Depen side effects in more detail. |
See also: methotrexate side effects in more detail. |
See also: sulfasalazine side effects in more detail. |
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Generic Availability | ||||||||||||||||||||||||||
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Depen prices |
View all methotrexate prices |
View all sulfasalazine prices |
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Dosage Form(s) Available | ||||||||||||||||||||||||||
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Brand Names | ||||||||||||||||||||||||||
Other penicillamine brands include: Cuprimine, D-Penamine, Depen Titratabs | Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, Trexall, Xatmep | Azulfidine, Azulfidine EN-tabs | ||||||||||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
3.2 hours |
15 hours |
10 hours |
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CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | ||||||||||||||||||||||||||
Category D
Positive evidence of risk
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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Drug Interactions | ||||||||||||||||||||||||||
A total of 105 drugs are known to interact with Depen:
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A total of 694 drugs are known to interact with methotrexate:
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A total of 258 drugs are known to interact with sulfasalazine:
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Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions | ||||||||||||||||||||||||||
First Approval Date | ||||||||||||||||||||||||||
November 08, 1978 |
December 07, 1953 |
June 20, 1950 |
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WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
N/A |
N/A |
N/A |
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More Information | ||||||||||||||||||||||||||
Patient resources | ||||||||||||||||||||||||||
Professional Resources | ||||||||||||||||||||||||||
Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.