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Depen (penicillamine) Disease Interactions

There are 3 disease interactions with Depen (penicillamine):


Penicillamine (Includes Depen) ↔ Bone Marrow Suppression

Severe Potential Hazard, High plausibility

Applies to: Bone Marrow Depression/Low Blood Counts

The use of penicillamine is contraindicated in patients with a history of penicillamine-related aplastic anemia or agranulocytosis.


  1. "Product Information. Cuprimine (penicillamine)." Merck & Co, Inc, West Point, PA.

Penicillamine (Includes Depen) ↔ Renal Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Renal Dysfunction

Penicillamine is considerably excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. The use of penicillamine is contraindicated in patients with renal dysfunction. Proteinuria and/or hematuria may develop during therapy and may lead to nephrotic syndrome. Monitoring for proteinuria and hematuria is recommended. Caution should be taken and routine monitoring of renal function is recommended.


  1. "Product Information. Cuprimine (penicillamine)." Merck & Co, Inc, West Point, PA.

Penicillamine (Includes Depen) ↔ Liver Disease

Moderate Potential Hazard, Moderate plausibility

Applies to: Cholelithiasis, Liver Disease

Cases of intrahepatic cholestasis and toxic hepatitis have been reported with the use of penicillamine. Care should be taken and liver function tests are recommended every six months for the duration of therapy.

Depen (penicillamine) drug Interactions

There are 165 drug interactions with Depen (penicillamine)

Depen (penicillamine) alcohol/food Interactions

There are 2 alcohol/food interactions with Depen (penicillamine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2018 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.