Comparing Clozapine vs Risperidone

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Clozapine

Risperidone

Prescribed for Schizophrenia. May also be prescribed off label for Borderline Personality Disorder, Paranoid Disorder.

Risperidone is an antipsychotic that relieves psychotic symptoms in people with schizophrenia or mania and is also used in the treatment of autistic disorder. Side effects are less likely at lower... View more

Prescription only

Ratings & Reviews

View all 58 reviews

View all 626 reviews

Drug Class

Atypical antipsychotics

Atypical antipsychotics

Side Effects

Commonly reported side effects include: hypotension, fever, tachycardia, constipation, dizziness, headache, nausea, sedated state, vomiting, and weight gain.

See the full clozapine side effects document.

Commonly reported side effects include: agitation, akathisia, anxiety, constipation, dizziness, drowsiness, dystonia, extrapyramidal reaction, nausea, rhinitis, and weight gain.

See the full risperidone side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	100 each
Dosage	100 mg
Per Unit^*	$1.05 - $1.29
Cost^*	$105.07 - $129.15

View all clozapine prices

Quantity	100 each
Dosage	1 mg
Per Unit^*	$1.46
Cost^*	$146.00

View all risperidone prices

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Generic Availability

Yes (this medicine)

Dosage Form(s) Available

Oral tablet
Oral tablet, disintegrating

Oral solution
Oral tablet
Oral tablet, disintegrating

Brand Names

Clopine, Clozapine Synthon, Clozaril, Denzapine, FazaClo, Versacloz Perseris, Risperdal, Risperdal Consta

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

10.3 hours

24 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category B No proven risk in humans

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 841 drugs are known to interact with clozapine:

424 major drug interactions (1274 brand and generic names)
410 moderate drug interactions (1815 brand and generic names)
7 minor drug interactions (61 brand and generic names)

A total of 642 drugs are known to interact with risperidone:

91 major drug interactions (341 brand and generic names)
546 moderate drug interactions (2194 brand and generic names)
5 minor drug interactions (26 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol can increase the nervous system side effects of cloZAPine such as dizziness, drowsiness... View more

RisperiDONE oral solution should not be mixed with tea or cola. It may be taken with water... View more

Disease Interactions

First Approval Date

September 26, 1989

December 29, 1993

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Patient resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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