Skip to Content


Generic Name: clozapine (KLOE za peen)
Brand Name: Clozaril, FazaClo, Versacloz

What is Versacloz?

Versacloz is an antipsychotic medicine works by changing the actions of chemicals in the brain.

Versacloz is used to treat severe schizophrenia, or to reduce the risk of suicidal behavior in people with schizophrenia or similar disorders.

Versacloz is available only from a certified pharmacy under a special program.

Versacloz may also be used for purposes not listed in this medication guide.

Important Information

Call your doctor right away if you have: chest pain, trouble breathing, fluttering in your chest, signs of infection (weakness, fever, sore throat, cold or flu symptoms), or if you feel like you might pass out.

Versacloz can cause severe dizziness, slow heartbeats, fainting, or seizures. Do not take more of this medicine than recommended.

Versacloz is not approved for use in psychotic conditions related to dementia. This medicine may increase the risk of death in older adults with dementia-related conditions.

Versacloz is available only from a certified pharmacy under a special program.

Before taking this medicine

You should not take Versacloz if you are allergic to it.

Versacloz is not approved for use in psychotic conditions related to dementia. This medicine may increase the risk of death in older adults with dementia-related conditions.

To make sure Versacloz is safe for you, tell your doctor if you have:

Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking Versacloz, do not stop taking it without your doctor's advice.

Clozapine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are taking clozapine.

How should I take Versacloz?

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Versacloz can be taken with or without food.

The orally-disintegrating tablet (FazaClo) can be taken without water. Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet. Use dry hands to remove the tablet and place it in your mouth. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. If desired, you may drink liquid to help swallow the dissolved tablet.

If your doctor has prescribed one-half of an orally-disintegrating tablet, you will need to break the tablet in half. Throw the other half away. Do not save it for later use.

Versacloz can lower blood cells that help your body fight infections, especially in women and older adults, and in people who are malnourished or have serious medical problems. This can make it easier for you to develop a serious or life-threatening infection. Your blood will need to be tested often. Your future treatments may be delayed based on the results of these tests.

If you need surgery, tell the surgeon ahead of time that you are using Versacloz. You may need to stop using the medicine for a short time.

You should not stop using Versacloz suddenly or you could have unpleasant withdrawal symptoms. Follow your doctor's instructions about tapering your dose.

Versacloz can have long lasting effects on your body. You may need frequent medical tests for a short time after you stop using this medicine.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. If you miss taking Versacloz for more than 2 days in a row, call your doctor before you start taking it again.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Versacloz?

Versacloz can cause severe dizziness, slow heartbeats, fainting, or seizures. Do not take more of this medicine than recommended. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Dizziness or severe drowsiness can cause falls, fractures, or other injuries.

Avoid drinking alcohol. Dangerous side effects could occur.

Versacloz side effects

Get emergency medical help if you have signs of an allergic reaction: hives, skin pain, rash that spreads and causes blistering or peeling; difficult breathing; swelling of your face, lips, tongue, or throat.

Serious and sometimes fatal infections may occur during treatment with Versacloz. Call your doctor right away if you have signs of infection such as: weakness, fever, swollen gums, sore throat, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing.

High doses or long-term use of Versacloz can cause a serious movement disorder that may not be reversible. Symptoms of this disorder include uncontrollable muscle movements of your lips, tongue, eyes, face, arms, or legs. The longer you take this medicine, the more likely you are to develop a serious movement disorder. The risk of this side effect is higher in women and older adults.

Also call your doctor at once if you have:

  • headache with chest pain and severe dizziness, pounding heartbeats or fluttering in your chest;

  • a light-headed feeling, like you might pass out;

  • sudden cough, rapid breathing, coughing up blood;

  • tight feeling in your neck or jaw, twitching or uncontrollable muscle movements;

  • a seizure (blackout-out or convulsions);

  • kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath;

  • liver problems--nausea, upper stomach pain, loss of appetite, tiredness, confusion, unusual bleeding, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;

  • high blood sugar--increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss; or

  • signs of inflammation in your body--easy bruising or bleeding, severe tingling or numbness, muscle weakness, upper stomach pain, jaundice (yellowing of the skin or eyes), chest pain, new or worsening cough, trouble breathing.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Versacloz?

Versacloz can cause a serious heart problem, especially if you use certain medicines at the same time. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with this medicine.

Taking Versacloz with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Many drugs can interact with Versacloz. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:

This list is not complete and many other drugs can interact with Versacloz. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

  • Your pharmacist can provide more information about Versacloz.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 18.01.

Date modified: March 06, 2018
Last reviewed: March 07, 2017