Comparing Amaryl vs Rybelsus
| Amaryl (glimepiride) | Rybelsus (semaglutide) |
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| Amaryl (glimepiride) | Rybelsus (semaglutide) |
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Prescription only
Prescribed for Type 2 Diabetes. Amaryl may also be used for purposes not listed in this medication guide. |
Prescription only
Rybelsus (semaglutide) is an oral medicine that can be used as a first-line medication to improve blood sugar control in adults over the age of 18 with type 2 diabetes. It works by mimicking the... View more |
Related suggestions Type 2 Diabetes
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| More about Amaryl (glimepiride) | More about Rybelsus (semaglutide) | ||||||||
| Ratings & Reviews | |||||||||
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Amaryl has an average rating of 7.1 out of 10 from a total of 19 ratings on Drugs.com. 58% of reviewers reported a positive effect, while 16% reported a negative effect. |
Rybelsus has an average rating of 6.5 out of 10 from a total of 309 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 22% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||
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View all Amaryl side effects |
View all Rybelsus side effects |
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| Drug Class | |||||||||
| Generic Availability | |||||||||
| Lower cost generic approved | |||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Rybelsus prices |
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| Dosage Forms | |||||||||
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| Brand Names | |||||||||
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N/A |
Other semaglutide brands include: Ozempic, Wegovy | ||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||
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3.4 hours |
168 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||
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A total of 505 drugs are known to interact with Amaryl:
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A total of 275 drugs are known to interact with Rybelsus:
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| Alcohol/Food/Lifestyle Interactions | |||||||||
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| Disease Interactions | |||||||||
| First Approval Date | |||||||||
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November 30, 1995 |
September 20, 2019 |
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| WADA Class View classifications | |||||||||
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N/A |
N/A |
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| More Information | |||||||||
| Patient Resources | |||||||||
| Professional Resources | |||||||||
| Related Treatment Guide | |||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.